Results 101 to 110 of about 26,475 (236)

Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention

, 2016
Radiation is the most potent mode of cancer therapy; however, resistance to radiation therapy results in tumor relapse and subsequent fatality. The cancer stem cell (CSC), which has better DNA repair capability, has been shown to contribute to tumor ...
Cecil Ross, Sweta Srivastava, Annapurna Pranatharthi   +2 more
core   +1 more source

APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer

Advanced Science
Radiotherapy is one of the most important adjuvant treatment methods for gastric cancer (GC). However, radioresistance remains a major clinical obstacle.
Dan Zu, Qimei Bao, Hanyi He, Yuke Zhong, Mingcong Deng, Yangchan Hu, Chunkai Zhang, Chen Liang, Yixing Huang, Haidong Liu, Xiao Li, Yanhua He, Guoyan Luo, Weixin Wu, Fenghui Guan, Shengfeng Xu, Min Liu, Albino Bacolla, Ji Jing, Yian Du, John A. Tainer, Yin Shi, Zu Ye, Xiangdong Cheng   +23 more
doaj   +1 more source

Nimotuzumab Combined With Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma and Nasopharyngeal Carcinoma: A Systematic Review and Meta‐Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This meta‐analysis of 18 studies (3962 patients) demonstrates that nimotuzumab combined with chemoradiotherapy significantly improves overall survival and progression‐free survival in locally advanced head and neck squamous cell carcinoma, without increasing severe toxicity.
Chengzheng Bao, Yue Zhang, Xiang Fei, Kaifeng Ji, Ming Jia, Zhijun Li, Chao Bian   +6 more
wiley   +1 more source

Predictive value of YKL-40 and c-Met as marker of chemo-radioresistance.

, 2015
Predictive value of YKL-40 and c-Met as marker of chemo-radioresistance.
Cristina Sonetto (724434), Rossella Spadi (724435), Rebecca Senetta (724432), Alberto Arezzo (724440), Isabella Castellano (464592), Eleonora Duregon (724433), Massimiliano Mistrangelo (724436), Paola Cassoni (627924), Patrizia Racca (724437), Fernando H. Munoz (724438), Umberto Ricardi (724439), Mario Morino (724442), Mauro Risio (724443), Mauro Papotti (314307), Luigi Chiusa (627919), Adele Cassenti (724441)   +15 more
core   +1 more source

Apoptotic cell-derived extracellular vesicles-MTA1 confer radioresistance in cervical cancer by inducing cellular dormancy

Journal of Translational Medicine
Background Radioresistance presents a major challenge in the treatment of cervical cancer (CC). Apoptotic tumor cells can create an “onco-regenerative niche,” contributing to radioresistance.
Yuan-Run Deng, Qiao-Zhi Wu, Wan Zhang, Hui-Ping Jiang, Cai-Qiu Xu, Shao-Cheng Chen, Jing Fan, Sui-Qun Guo, Xiao-Jing Chen   +8 more
doaj   +1 more source

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6‐Methyladenosine Modification

Cancer Science, EarlyView.
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Zhuoyi Wu, Ruyun Xu, Ju Fang, Bing Liu, Cao Zhang, Shangxin Zhang, Jing Ni   +6 more
wiley   +1 more source

miR-135b contributes to radioresistance in U87 cells.

, 2014
(A) miR-135b expression increases in U87R cells, compared to U87 cells. (B and C) miR-135b expression was modulated using miR-135b inhibitor or mimics respectively.
Songhua Xiao (322277), Qing Liu (20889), Zhen Yang (107412), Ming Wu (238132), Yiwei Liao (635768), Jia Zhao (511806), Ruiyan Lv (635767)   +6 more
core   +1 more source

Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks [PDF]

, 2018
Summary: We have uncovered a role for Jumonji inhibitors in overcoming radioresistance through KDM5B inhibition. Pharmacological blockade of Jumonji demethylases with JIB-04 leads to specific accumulation of H3K4me3 at sites marked by γH2AX and impaired ...
Das, Amit K., Lei Wang, Peña Llopis, Samuel, Tram Anh Tran, Samuel Peña-Llopis, Juan Bayo, Bayo Fina, Juan Miguel, Amit K. Das, Wang, Lei, Martinez, Elisabeth D., Tran, Tram Anh, Elisabeth D. Martinez   +11 more
core   +1 more source

Ibrutinib inactivates BMX-STAT3 in glioma stem cells to impair malignant growth and radioresistance

, 2018
Targeting glioma stem cells by ibrutinib inhibits malignant growth and overcomes glioblastoma radioresistance.
Yaping Chen, Ryan C. Gimple, Tao Jiang, Wenchao Zhou, Xiu-Wu Bian, Qing Liu, Shideng Bao, Qiulian Wu, Olga A. Guryanova, Leo Kim, Yi-Fang Ping, Wei Wang, Hua Feng, Zhicheng He, Jeremy N. Rich, Wei Zhang, Wenying Wang, Xiaoguang Fang, Hsiang-Fu Kung, Jennifer S. Yu, Yu Shi, Xiuxing Wang, Jingjing Wu, Cong Chen, Zhi Huang, Chong Liu   +25 more
core   +1 more source

FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer

Cell Death Discovery
Radiotherapy is a cornerstone treatment for non-small cell lung cancer (NSCLC), but its efficacy is frequently limited by tumor-intrinsic radioresistance.
Xiaoyu Pu, Kexin Chen, Lihua Dong, Junxuan Yi, Mingwei Wang, Xinfeng Wei, Mingqi Zhao, Mengdie Zhao, Xinyan Wang, Lijuan Ding, Shunzi Jin   +10 more
doaj   +1 more source