Results 121 to 130 of about 26,475 (236)

Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells

Experimental Hematology & Oncology
Radiotherapy is one of the mainstream approaches for cancer treatment, although the clinical outcomes are limited due to the radioresistance of tumor cells. Hypoxia and metabolic reprogramming are the hallmarks of tumor initiation and progression and are
Zheng Shi, Cuilan Hu, Xiaogang Zheng, Chao Sun, Qiang Li   +4 more
doaj   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Schemetic illustration of the putative roles of TIP-1 in the radioresistance of malignant gliomas.

, 2012
Schemetic illustration of the putative roles of TIP-1 in the radioresistance of malignant gliomas.
Miaojun Han (134817), Zhaozhong Han (134826), Hua-Tang Zhang (134823), Hailun Wang (134820)   +3 more
core   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

LncRNA-EME1 enhances BRCA1 recruitment and alters repair of DNA damage in cervical cancer radioresistance

Non-coding RNA Research
Background: Cervical cancer is a significant cause of mortality in women globally, and radioresistance limits the effectiveness of standard radiotherapy treatment.
Qing Li, Zhenyu Zhou, Xiaoying Li, Qiongyu Lan   +3 more
doaj   +1 more source

Vision and implementation for the first U.S. carbon ion therapy center part I: Clinical rationale and the need for CIRT in the United States

Journal of Applied Clinical Medical Physics, Volume 27, Issue 11, November 2026.
Abstract Carbon ion radiotherapy (CIRT) has evolved into an established clinical modality over the past three decades. Owing to its unique physical and biological characteristics, CIRT has demonstrated favorable outcomes for selected malignancies characterized by radioresistance, proximity to critical organs, locally advanced disease requiring safe ...
Xiaoying Liang, Chris J Beltran
wiley   +1 more source

Confronting Melanoma Radioresistance: Mechanisms and Therapeutic Strategies

Melanoma is a highly aggressive skin cancer with survival rates varying significantly based on stage and genomic characteristics. While localized melanoma has favorable outcomes, metastatic melanoma is associated with poor prognosis and limited treatment
Ielizaveta Gorodetska, Alexander Schulz, Anna Dubrovska, Gerhard Behre   +3 more
core   +1 more source

MGP_HNSC32: A H&E Morphology‐Derived 32‐Gene Prognostic Signature in Head and Neck Squamous Cell Carcinoma

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Head and neck squamous cell carcinoma (HNSC) exhibits substantial molecular and morphological heterogeneity, yet current morphology‐based prognostic models often lack biological interpretability. We developed a transformer‐based computational framework (CTransPath) to virtually predict gene expression directly from hematoxylin and eosin (H&E ...
Di Zhao, Zhiheng Huang, Jing Xu, Zheng Zhang, Jochen Hess, Bohai Feng   +5 more
wiley   +1 more source

SIRT7 Mediated‐PTEN Desuccinylation Drives Gastric Tumorigenesis by Activating PI3K/AKT Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
SIRT7 is upregulated in gastric cancer (GC). SIRT7‐mediated desuccinylation of PTEN at K322/K330 promotes its degradation, thereby activating the PI3K/AKT signaling pathway and ultimately driving GC progression. ABSTRACT SIRT7 is linked to cancer, yet its function in gastric cancer (GC) remains unclear.
Bingling Liao, Sheng Hu, Qilin Zhang, Qihua Xu, Tianning Tian   +4 more
wiley   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source