Results 81 to 90 of about 26,475 (236)

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

miR-214 promotes radioresistance in human ovarian cancer cells by targeting PETN

, 2017
Ovarian cancer is one of the leading causes of death among gynecological malignancies. Increasing evidence indicate that dysregulation of microRNAs (miRNAs) plays an important role in tumor radioresistance.
Qin Zhang, Shuxiang Zhang
core   +1 more source

FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer

Journal of Experimental & Clinical Cancer Research
Background The development of radioresistance seriously hinders the efficacy of radiotherapy in lung cancer. However, the underlying mechanisms by which radioresistance occurs are still incompletely understood.
Zhiyuan Zhou, Bin Zhang, Yue Deng, Suke Deng, Jie Li, Wenwen Wei, Yijun Wang, Jiacheng Wang, Zishan Feng, Mengjie Che, Xiao Yang, Jingshu Meng, Yan Li, Yan Hu, Yajie Sun, Lu Wen, Fang Huang, Yuhan Sheng, Chao Wan, Kunyu Yang   +19 more
doaj   +1 more source

gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination

iScience
Summary: Adjuvant radiation therapy is a common treatment for breast cancer, yet its effectiveness is often limited by radioresistance in patients. Identifying novel targets to combat this radioresistance is imperative.
Yamei Han, Mingming Xiao, Shaorong Zhao, Han Wang, Rui Li, Bo Xu   +5 more
doaj   +1 more source

The Choice Between Definitive Radiotherapy and Surgery for Cervical Cancer With Different Histology in Current Clinical Practice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT For cervical cancer, the choice between definitive radiotherapy (RT) and surgery has long been a topic of debate. Clinical factors, including histology and tumor burden, have been examined in prior studies. Given recent advances in RT and the incorporation of concurrent chemotherapy, our study seeks to assess the optimal treatment modality for
Yu‐Lun Wu, Chen‐Wei Ho, Wen‐Shiung Liou, Chun‐Hao Yin, Jin‐Shuen Chen, Yao‐Shen Chen, Yu‐Wei Lin, Ju‐Chun Chien   +7 more
wiley   +1 more source

MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance by Targeting A20/NF-κB Signaling Pathway

, 2017
Radioresistance poses a major challenge in nasopharyngeal carcinoma (NPC) treatment, but little is known about how miRNA regulates this phenomenon. In this study, we investigated the function and mechanism of miR-125b in NPC radioresistance, one of ...
Xu Ye, Li-Na Li, Hong-Mei Yi, Zhen Zheng, Shan-Shan Lu, Wei Huang, Hong Yi, Xin-Hui Li, Ta Xiao, Zhi-Qiang Xiao, Jia-Quan Qu   +10 more
core   +1 more source

Image_1_Prognostic risk analysis related to radioresistance genes in colorectal cancer.tif

, 2023
BackgroundRadiotherapy (RT) is one of the most important treatments for patients with colorectal cancer (CRC). Radioresistance is the crucial cause of poor therapeutic outcomes in colorectal cancer. However, the underlying mechanism of radioresistance in
Haoren Qin (14442072), Haipeng Li (274506), Siwei Zhu (400113), Hui Wang (30400), Heng Zhang (320479), Wanjun Sun (11620305), Xipeng Zhang (767297), Shiwu Zhang (85788), Qiong Xu (204847)   +8 more
core   +1 more source

Cancer-associated fibroblast-induced lncRNA WARS2-IT1 confers radioresistance of colorectal cancer via enhancing HIF-1α stability

Cell Death and Disease
The tumor microenvironment in colorectal cancer (CRC) is marked by a diverse and abundant population of cancer-associated fibroblasts (CAFs), which play a crucial role in radioresistance.
Yuanqi Li, Wei Dai, Xiao Zheng, Qi Wang, Jinping Zhang, Xiangyin Kong, Jingting Jiang, You Zhou   +7 more
doaj   +1 more source

C–X–C Motif Chemokine Receptor 4 (CXCR4)‐Targeted Biologically Guided Proton Spatially Fractionated Radiotherapy for Bulky Limited‐Stage Small Cell Lung Cancer

Precision Radiation Oncology, EarlyView.
A newly proposed proton spatially fractionated radiotherapy guided by biological imaging Abstract Background and Purpose To evaluate the feasibility and dosimetric safety of integrating C–X–C motif chemokine receptor 4 (CXCR4)‐targeted tracer 18F‐AlF‐NOTA‐QHY‐04 positron emission tomography imaging with biologically guided proton spatially fractionated
Keru Pu, Tengxiang Li, Shengnan Xu, Xue Sha, Qingtao Qiu, Jinming Yu, Yong Yin, Jie Liu   +7 more
wiley   +1 more source

Radioresistance Mechanisms in Head and Neck Cancer [PDF]

Clinical and Experimental Otorhinolaryngology
Head and neck cancer (HNC) is not only one of the deadliest malignant tumors but also significantly impacts patient quality of life because of its proximity to numerous critical organs.
Quoc Khanh Nguyen, Bon Seok Koo
doaj   +1 more source