Results 61 to 70 of about 26,475 (236)

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

WISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice. [PDF]

PLoS ONE, 2014
Cancer cells that survive fractionated irradiation can be radioresistant and cause tumor recurrence. However, the molecular mechanisms underlying the development of radioresistance in cancer cells remain elusive.
Wen-Feng Li, Li Zhang, Hai-Ying Li, Si-Si Zheng, Liang Zhao   +4 more
doaj   +1 more source

Pancreatic cancer cells hijack tumor suppressive microRNA-26a to promote radioresistance and potentiate tumor repopulation

Heliyon
Pancreatic cancer is one of the most lethal cancers with significant radioresistance and tumor repopulation after radiotherapy. As a type of short non-coding RNA that regulate various biological and pathological processes, miRNAs might play vital role in
Ming-jie Jiang, Chen-jing Lin, Fu-rao Liu, Zhu Mei, Dian-na Gu, Ling Tian   +5 more
doaj   +1 more source

Hypoxic tumour cell-derived exosomal miR-340-5p promotes radioresistance of oesophageal squamous cell carcinoma via KLF10

Journal of Experimental & Clinical Cancer Research, 2021
Background Radiotherapy resistance is a major obstacle in the treatment of oesophageal squamous cell carcinoma (OSCC). Hypoxia is a critical cause of radioresistance.
Fangyu Chen, Bing Xu, Jie Li, Xi Yang, Junjie Gu, Xijuan Yao, Xinchen Sun   +6 more
doaj   +1 more source

Wnt signaling induces radioresistance through upregulating HMGB1 in esophageal squamous cell carcinoma

, 2018
Although many articles have uncovered that Wnt signaling is involved in radioresistance, the mechanism is rarely reported. Here we generated two radioresistant cells rECA109 and rKyse150 from parental esophageal cancer cells ECA109 and Kyse150.
Guichun Huang, Xiaoyuan Chu, Jun Yi, Leilei Tao, Longbang Chen, Haizhu Song, Yuanyuan Zhao   +6 more
core   +1 more source

DataSheet_2_Prognostic risk analysis related to radioresistance genes in colorectal cancer.xlsx

, 2023
BackgroundRadiotherapy (RT) is one of the most important treatments for patients with colorectal cancer (CRC). Radioresistance is the crucial cause of poor therapeutic outcomes in colorectal cancer. However, the underlying mechanism of radioresistance in
Haoren Qin (14442072), Haipeng Li (274506), Siwei Zhu (400113), Hui Wang (30400), Heng Zhang (320479), Wanjun Sun (11620305), Xipeng Zhang (767297), Shiwu Zhang (85788), Qiong Xu (204847)   +8 more
core   +1 more source

Hypoxic tumor exosomes suppress macrophage inflammation and ferroptosis via NDUFV2 to enhance bystander tumor radioresistance

Cell Death and Disease
Hypoxia-induced radioresistance presents a major barrier to effective radiotherapy of non-small cell lung cancer (NSCLC), while the underlying role of macrophages remaining elusive.
Jialing Zhang, Xiaoya Jin, Maidina Abulaihaiti, Xinglong Liu, Liang Zeng, Yuqi Xiao, Yan Pan, Yang Bai, Yanwu Xu, Chunlin Shao, Jianghong Zhang   +10 more
doaj   +1 more source

Growth Differentiation Factor 15 as a Cerebrospinal Fluid Biomarker for the Diagnosis and Prognosis of Leptomeningeal Metastasis

Annals of Neurology, EarlyView.
Objective As leptomeningeal metastasis (LM) has a poor prognosis, reliable cerebrospinal fluid (CSF) diagnostic biomarkers are urgently needed. This study evaluated the diagnostic value of CSF growth differentiation factor 15 (GDF15) in LM from lung adenocarcinoma (LUAD) and breast cancer (BC).
Haoyu Ruan, Jie Li, Fuhai Wang, Lei Zhang, Jie Luo, Yuan Mu, Ting Wang, Yuqing Wu, Jingping Liu, Yunyun Ning, Xuan Deng, Ming Guan, Jian Xu   +12 more
wiley   +1 more source

GSK3β overexpression reverses radioresistance of U87R cells.

, 2014
(A) Transfection of GSK3β vector increased GSK3β protein expression.
Songhua Xiao (322277), Qing Liu (20889), Zhen Yang (107412), Ming Wu (238132), Yiwei Liao (635768), Jia Zhao (511806), Ruiyan Lv (635767)   +6 more
core   +1 more source

DataSheet_1_Prognostic risk analysis related to radioresistance genes in colorectal cancer.docx

, 2023
BackgroundRadiotherapy (RT) is one of the most important treatments for patients with colorectal cancer (CRC). Radioresistance is the crucial cause of poor therapeutic outcomes in colorectal cancer. However, the underlying mechanism of radioresistance in
Haoren Qin (14442072), Haipeng Li (274506), Siwei Zhu (400113), Hui Wang (30400), Heng Zhang (320479), Wanjun Sun (11620305), Xipeng Zhang (767297), Shiwu Zhang (85788), Qiong Xu (204847)   +8 more
core   +1 more source