Results 51 to 60 of about 26,475 (236)

Deltex E3 Ubiquitin Ligase 3L confers radioresistance in prostate cancer via Akt pathway [PDF]

, 2020
Purpose: To determine the effect of Deltex E3 Ubiquitin Ligase 3L (DTX3L) on the radioresistance of prostate cancer (PCa).Methods: A PCa cell model of radioresistance was established via exposure of cancer cell lines to fractionated radiation.
Lv, Bodong, Fan, Shufeng, Zhang, Zhitian, Xiang, Junyi, Yang, Hui, Hui Yang, Bodong Lv, Junyi Xiang, Zhitian Zhang, Shufeng Fan   +9 more
core   +1 more source

LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73

Journal of Translational Medicine, 2023
Background The ubiquitin protein ligase E3C (UBE3C) has been reported to play an oncogenic role in breast cancer (BRCA). This work further investigates the effect of UBE3C on the radioresistance of BRCA cells. Methods Molecules linking to radioresistance
Yansu Wang, Ming Liu, Xiaoqian Liu, Xianling Guo   +3 more
doaj   +1 more source

DLX5 Promotes Radioresistance in Renal Cell Carcinoma by Upregulating c-Myc Expression

Frontiers in Bioscience-Landmark
Background: Renal cell carcinoma (RCC) is a prevalent and aggressive kidney cancer with notable metastatic potential. While radiotherapy is effective for treating metastatic RCC, the emergence of radioresistance presents a major ...
Danfei Hu, Mingyao Li, Xiaodong Chen
doaj   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

STAT3 Contributes to Radioresistance in Cancer [PDF]

Frontiers in Oncology, 2020
Radiotherapy has been used in the clinic for more than one century and it is recognized as one of the main methods in the treatment of malignant tumors. Signal Transducers and Activators of Transcription 3 (STAT3) is reported to be upregulated in many tumor types, and it is believed to be involved in the tumorigenesis, development and malignant ...
Xuehai Wang, Xin Zhang, Xin Zhang, Chen Qiu, Ning Yang, Ning Yang   +5 more
openaire   +3 more sources

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

Impacts of potential radioresistance driver genes on known radioresistance markers.

, 2019
Impacts of differentially expressed genes with directly underlying copy number alterations in radioresistant DU145 (a) and radioresistant LNCaP (b) on known markers of radioresistance.
Ielizaveta Gorodetska (7817480), Michael Seifert (188260), Caroline Börner (7817483), Claudia Peitzsch (7817477), Anna Dubrovska (105746), Barbara Klink (391506)   +5 more
core   +1 more source

Proteomic signatures of radioresistance: Alteration of inflammation, angiogenesis and metabolism-related factors in radioresistant oesophageal adenocarcinoma

Cancer Treatment and Research Communications, 2021
: The clinical management of locally advanced oesophageal adenocarcinoma (OAC) involves neoadjuvant chemoradiotherapy (CRT), but as radioresistance remains a major clinical challenge, complete pathological response to CRT only occurs in 20–30% of ...
Simone Marcone, Amy Buckley, Colm J. Ryan, Mark McCabe, Niamh Lynam-Lennon, David Matallanas, Jacintha O`Sullivan, Susan Kennedy   +7 more
doaj   +1 more source

[Establishment of Human Lung Adenocarcinoma Radioresistant Cell Lines
and the Mechanism of Radioresistance].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2023
Radiotherapy is one of the most common treatments for lung cancer, and about 40%-50% of patients after radiotherapy will appear uncontrolled or recurrence in the case of local tumors. Radioresistance is the predominant cause of local therapeutic failure.
Jingjing ZHANG, Shenglin MA, Qiong WU
openaire   +2 more sources