Results 41 to 50 of about 26,475 (236)

SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance [PDF]

, 2018
Background Radioresistance is the major cause of cancer treatment failure. Additionally, splicing dysregulation plays critical roles in tumorigenesis. However, the involvement of alternative splicing in resistance of cancer cells to radiotherapy remains ...
Sheng, Junxiu, Bing Sun, Lu Bai, Chundong Gu, Zhang, Ge, Lin Zhang, Gu, Hong, Pan Qin, Lv, Yuesheng, Qin, Pan, Judy M. Coulson, Zhao, Jinyao, Songshu Meng, Zhao, Qingzhi, Deng, Xiaoqin, Qi, Yangfan, Yu Sun, Wenjing Zhang, Yang, Quan, Quan Yang, Jinyao Zhao, Lei Chen, Meng, Songshu, Ge Zhang, Liu, Han, Li, Xiaoling, Liu, Quentin, Hong Gu, Chen, Lei, Han Liu, Xiaoqin Deng, Zhang, Wenjing, Zhang, Lin, Quentin Liu, Wang, Yang, Xiaoling Li, Sun, Yu, Yuesheng Lv, Gu, Chundong, Yangfan Qi, Coulson, Judy M, Qingzhi Zhao, Bai, Lu, Yang Wang, Sun, Bing, Junxiu Sheng   +45 more
core   +1 more source

Hypoxic Radioresistance: Can ROS Be the Key to Overcome It? [PDF]

Cancers, 2019
Radiotherapy is a mainstay treatment for many types of cancer and kills cancer cells via generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological ROS inducers, therefore, has been widely investigated as an approach to enhance aerobic radiosensitization.
Wang, Hui, Jiang, Heng, Van De Gucht, Melissa, De Ridder, Mark   +3 more
openaire   +3 more sources

The Role of Canonical Wnt Signaling in Regulating Radioresistance

Cellular Physiology and Biochemistry, 2018
Radioresistance is a major obstacle in radiotherapy for cancer, and strategies are needed to overcome this problem. Currently, radiotherapy combined with targeted therapy such as inhibitors of phosphoinosotide 3-kinase/Akt and epidermal growth factor ...
Yuanyuan Zhao, Leilei Tao, Jun Yi, Haizhu Song, Longbang Chen   +4 more
doaj   +1 more source

HOXA1 is a radioresistance marker in multiple cancer types

Frontiers in Oncology, 2022
Radiotherapy is an important therapeutic method for patients with cancer. However, radioresistance can cause treatment failure. Thus, there is an urgent need to investigate mechanisms of radioresistance and identity markers that could be used to predict ...
Lu He, Min Liang, Min Liang, Weisheng Guo, Jinquan Liu, Yi Yu   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Prognostic risk analysis related to radioresistance genes in colorectal cancer [PDF]

, 2023
BackgroundRadiotherapy (RT) is one of the most important treatments for patients with colorectal cancer (CRC). Radioresistance is the crucial cause of poor therapeutic outcomes in colorectal cancer. However, the underlying mechanism of radioresistance in
Hui Wang, Wanjun Sun, Heng Zhang, Qiong Xu, Xipeng Zhang, Shiwu Zhang, Haoren Qin, Haipeng Li, Siwei Zhu, Li, Haipeng, Zhang, Xipeng, Wang, Hui, Sun, Wanjun, Qin, Haoren, Zhu, Siwei, Zhang, Shiwu, Xu, Qiong, Zhang, Heng   +17 more
core   +1 more source

PI3K/mTOR inhibitors promote G6PD autophagic degradation and exacerbate oxidative stress damage to radiosensitize small cell lung cancer

Cell Death and Disease, 2023
Our previous study revealed that PI3K/AKT/mTOR signaling was associated with SCLC radioresistance. SBC2 cells were used as primary radioresistance models, while H446 cells were continuously exposed to ionizing radiation (IR) to develop acquired ...
Huan Deng, Yamei Chen, Li Wang, Yibi Zhang, Qingqing Hang, Peijing Li, Peng Zhang, Jing Ji, Hai Song, Ming Chen, Ying Jin   +10 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Factors influencing human tumor radioresistance

, 1994
The first part of this paper reviews factors which modulate intrinsic radioresistance including free radical scavengers, chemical and enzymatic repair of DNA, chromatin conformation, cell cycle checkpoints and signal transduction processes. In the second
G Batist, MA Alaoui-Jamali, S Lehnert
core   +1 more source