Results 31 to 40 of about 26,475 (236)
Cancer stem cells and radioresistance [PDF]
International Journal of Radiation Biology, 2014 Radiation therapy has made significant contributions to cancer treatment. However, despite continuous improvements, tumor recurrence and therapy resistance still occur in a high proportion of patients. One underlying reason for this radioresistance might be attributable to the presence of cancer stem cells (CSC).
Kiera, Rycaj, Dean G, Tang
openaire +2 more sources
Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells
Cells, 2021 Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and the mechanism remains unclear.
Dinisha Kamble +3 more
doaj +1 more source
Lactylation-Driven PROS1-TYRO3-CARF Signaling Promotes Therapy-Induced Senescence Escape and Radioresistance in Meningioma. [PDF]
Adv Sci (Weinh)A glycolysisâdriven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Wang Z +12 more
europepmc +2 more sources
Radioresistance in carcinoma of the breast
The Breast, 2004 Radiotherapy plays an important role in the management of breast cancer. Whilst its role in achieving local control following surgery in patients with early stage cancer is well established, there is still unclear evidence to explain the factors governing radioresistance in patients who develop recurrences both in the breast and axilla.
J K A, Jameel +3 more
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Heliyon, 2023 Radioresistance is the major factor of glioblastoma multiforme (GBM) treatment failure and relapse. Hypoxia and autophagy are linked to radioresistance and poor prognosis in solid tumors, but mechanisms remain unknown.
Jielin Wei +8 more
doaj +1 more source
Cancer stem cells and signaling pathways in radioresistance
, 2016 Radiation therapy (RT) is one of the most important strategies in cancer treatment. Radioresistance (the failure to RT) results in locoregional recurrence and metastasis.
Graham, P +8 more
core +1 more source
Frontiers in Genetics, 2022 Background: Radioresistance in head and neck squamous cell carcinoma (HNSCC) patients means response failure to current treatment. In order to screen radioresistant biomarkers and mechanisms associated with HNSCC, differentially expressed genes (DEGs ...
Xiaojun Tang +8 more
doaj +1 more source
Summary of potential radioresistance drivers.
, 2019 Summary of potential radioresistance drivers.
Ielizaveta Gorodetska (7817480) +5 more
core +1 more source
LIG4 mediates Wnt signalling-induced radioresistance [PDF]
, 2016 Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs).
Jun, Sohee +12 more
core +1 more source
Are Cancer Stem Cells Radioresistant? [PDF]
Future Oncology, 2010 Based on findings that cancer cell clonogens exhibit stem cell features, it has been suggested that cancer stem-like cells are relatively radioresistant owing to different intrinsic and extrinsic factors, including quiescence, activated radiation response mechanisms (e.g., enhanced DNA repair, upregulated cell cycle control mechanisms and increased ...
Walter N, Hittelman +3 more
openaire +2 more sources