Results 21 to 30 of about 26,475 (236)
Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium-Dependent ANXA2<sup>+</sup>sEVs Driving M2 Polarization of TAMs. [PDF]
Adv Sci (Weinh)SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Fang Y +18 more
europepmc +2 more sources
Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR-296-5p/Snail Axis. [PDF]
Adv Sci (Weinh)Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Seok HJ +4 more
europepmc +2 more sources
Musashi-1 Drives Radioresistance and Stemness in Head and Neck Squamous Cell Carcinoma via a Radioresistant FaDu Model. [PDF]
Cancer SciFractionated irradiation generated radioresistant F‐IRR cells with enhanced CSC properties despite slower proliferation. MSI1 was strongly upregulated and functionally promoted stemness, tumorigenicity, and radiation resistance. JNK signaling acted upstream of MSI1, while JNK inhibition suppressed these malignant traits, identifying the JNK–MSI1 axis ...
Kang NE +5 more
europepmc +2 more sources
CircRNAs in Tumor Radioresistance
Biomolecules, 2022 Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs’ leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discovered, such as regulating transcription and translation ...
Yining Gao +7 more
openaire +3 more sources
Detection of acquired radioresistance in breast cancer cell lines using Raman spectroscopy and machine learning [PDF]
, 2021 Radioresistance—a living cell’s response to, and development of resistance to ionising radiation—can lead to radiotherapy failure and/or tumour recurrence.
Elfick, Alistair P D +13 more
core +1 more source
BMC Cancer, 2021 Background Currently, no clinically useful biomarkers for radioresistance are available in head and neck squamous cell carcinoma (HNSCC). This study assesses the usefulness of Cell Line Microarray (CMA) method to enhance immunohistochemical screening of ...
Johannes Routila +5 more
doaj +1 more source
, 2022 Background and purpose: Radioresistance remains a significant challenge in tumor therapy. This systematic review aims to demonstrate the role of long non-coding RNA (lncRNA) in cancer radioresistance/radiosensitivity.Material and methods: The electronic ...
Wenhan Wu (3842482) +2 more
core +1 more source
, 2022 Background and purpose: Radioresistance remains a significant challenge in tumor therapy. This systematic review aims to demonstrate the role of long non-coding RNA (lncRNA) in cancer radioresistance/radiosensitivity.Material and methods: The electronic ...
Wenhan Wu (3842482) +2 more
core +1 more source
Journal of Translational Medicine, 2023 Background Long non-coding RNA (lncRNA) HOTAIR acts importantly in liver cancer development, but its effect on radioresistance remains poorly understood.
Ruifeng Pei +8 more
doaj +1 more source
IGFL2-AS1, a Long Non-Coding RNA, Is Associated with Radioresistance in Colorectal Cancer
, 2023 Precise prediction of radioresistance is an important factor in the treatment of colorectal cancer (CRC). To discover genes that regulate the radioresistance of CRCs, we analyzed an RNA sequencing dataset of patient-originated samples.
Lee, Jeeyong +11 more
core +1 more source