Results 11 to 20 of about 26,475 (236)
Inhibition of livin overcomes radioresistance in nasopharyngeal carcinoma cells.
PLoS ONE, 2020 BACKGROUND AND AIMS:Radiotherapy is one of the major remedies for the treatment of cancer, including nasopharyngeal carcinoma (NPC). Radioresistance occurs very often in target cells that is a large drawback in cancer treated with radiotherapy.
Fei Ma +8 more
doaj +2 more sources
Drivers of Radioresistance in Prostate Cancer [PDF]
Journal of Clinical Medicine, 2022 Prostate cancer (PCa) is the second most commonly diagnosed cancer worldwide. Radiotherapy remains one of the first-line treatments in localised disease and may be used as monotherapy or in combination with other treatments such as androgen deprivation therapy or radical prostatectomy.
Liam King +7 more
openaire +4 more sources
The miR-199a-3p regulates the radioresistance of esophageal cancer cells via targeting the AK4 gene
Cancer Cell International, 2018 Background MiRNAs was recognized as vital regulators involved in cancer development. Radioresistance remains a major obstacle for effective treatment of cancers. The mechanisms on the miRNA-mediated radioresistance of cancers are still poorly understood.
Chunbao Zang +3 more
doaj +2 more sources
Cell Death and Disease, 2023 Radioresistance limits the efficacy of radiotherapy against breast cancer, especially the most lethal subtype of breast cancer, triple-negative breast cancer (TNBC).
Qun Liu +8 more
doaj +2 more sources
Exosomes in Cancer Radioresistance [PDF]
Frontiers in Oncology, 2019 Radiation is a mainstay of cancer therapy. Radioresistance is a significant challenge in the treatment of locally advanced, recurrent and metastatic cancers. The mechanisms of radioresistance are complicated and still not completely understood.
Jie Ni +12 more
doaj +3 more sources
Targeting the NR3C1-ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer. [PDF]
Cancer SciThe glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Yang J +7 more
europepmc +3 more sources
Clinical and Translational Radiation Oncology, 2023 Introduction: Neoadjuvant radiotherapy is successfully used in rectal cancer to improve overall survival. However, treatment response is both unpredictable and variable. There is strong evidence to show that the phenomenon of tumour hypoxia is associated
Matthew Fok +9 more
doaj +2 more sources
Atomoxetine suppresses radioresistance in glioblastoma via circATIC/miR-520d-5p/Notch2-Hey1 axis
Cell Communication and SignalingBackground Resistance acquired after radiotherapy is directly related to the failure of various cancer treatments, including GBM. Because the mechanism for overcoming radioresistance has not yet been clearly identified, the development of diagnostic and ...
Hyun Jeong Seok +4 more
doaj +2 more sources
DTX3 Suppresses the NPM3-RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance. [PDF]
Adv Sci (Weinh)Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Xiao JH +9 more
europepmc +2 more sources
Tumor microenvironment and radioresistance [PDF]
Experimental & Molecular Medicine, 2021 AbstractMetastasis is not the result of a random event, as cancer cells can sustain and proliferate actively only in a suitable tissue microenvironment and then form metastases. Since Dr. Stephen Paget in the United Kingdom proposed the seed and soil hypothesis of cancer metastasis based on the analogy that plant seeds germinate and grow only in ...
Suwa, Tatsuya +3 more
openaire +2 more sources