Results 91 to 100 of about 10,067 (250)
Methodological advancements in microfluidic and carbonylation PET radiochemistry [PDF]
, 2016 Along with the progress of PET as a powerful imaging tool in medicine, there has been increasing demand for new labeling methods. The main aim of this PhD dissertation was to develop novel labeling methodologies using the positron emitter carbon-11.
Dahl, Kenneth
core +1 more source
Chemistry–Methods, Volume 6, Issue 1, January 2026.Accurate and simple liquid chromatography‐tandem mass spectrometry methods for measuring Am for [18F]fluoride on two rapidly derived surrogates, [18F]FAY and [18F]PCBSF, can serve as forensic tools for investigating the sources of carrier, Am determinations during routine tracer productions and be applied to radiotracers lacking a strong ultraviolet ...
Nicholas R. Ellin +8 more
wiley +1 more source
Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine
Pharmaceuticals, 2023 The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications.
Jason Beaufrez +3 more
doaj +1 more source
Synthese des 18F-markierten Coenzyms Uridindiphosphatglucose als Basis für die 18F-Glykosylierung von Glykoproteinen [PDF]
, 2000 The chemo-enzymatic radiosynthesis of no carrier added (n.c.a.) uridine diphospho-2-deoxy- 2-[$^{18}$F]fluoro-$\alpha$-D-glucose (UDP-[$^{18}$F]FGlc) was developed.
Prante, Olaf
core
Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). [PDF]
, 2019 BackgroundConventional scale production of small batches of PET tracers (e.g. for preclinical imaging) is an inefficient use of resources. Using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), we demonstrate that simple microvolume radiosynthesis ...
Chen, Bao Ying +5 more
core +1 more source
Medicinal Research Reviews, Volume 46, Issue 1, Page 203-237, January 2026.ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller +5 more
wiley +1 more source
Automated One-pot Radiosynthesis of [11C]S-adenosyl Methionine [PDF]
Current Radiopharmaceuticals, 2017 Glycine N-methyltransferase is an enzyme overexpressed in some neoplastic tissues. It catalyses the methylation of glycine using S-adenosyl methionine (SAM or AdoMet) as substrate. SAM is involved in a great variety of biochemical processes, including transmethylation reactions.
Zoppolo, Florencia +4 more
openaire +2 more sources
ChemMedChem, Volume 20, Issue 24, December 15, 2025.Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda +4 more
wiley +1 more source
Improved synthesis of [ 11 C]methylaminobenzovesamicol [PDF]
, 1992 An efficient two‐step synthesis of the potential cholinergic neuronal mapping tracer [ 11 C]methylaminobenzovesamicol (MABV) is described. A tert ‐butoxycarbonyl protecting group was used to activate the aniline nitrogen of aminobenzovesamicol toward ...
Ayyangar +16 more
core +1 more source
Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A) [PDF]
, 2022 Barbara Wenzel +7 more
openalex +1 more source