Results 91 to 100 of about 7,738 (197)

Multi‐organ kinetic modeling for Na[18F]F pre‐clinical total‐body PET studies

Medical Physics, Volume 52, Issue 2, Page 924-937, February 2025.
Abstract Background Total‐body positron emission tomography (PET), already well‐established in the pre‐clinical setting, makes it possible to study multi‐parameters in biological systems as a whole, rather than focusing on single tissues analysis. Simultaneous kinetic analysis of multiple organs poses some daunting new challenges.
Jose Benitez‐Aurioles, Paul S. Clegg, Carlos J. Alcaide‐Corral, Catriona Wimberley, Adriana A. S. Tavares   +4 more
wiley   +1 more source

[18F]Trifluoroiodomethane – Enabling Photoredox‐mediated Radical [18F]Trifluoromethylation for Positron Emission Tomography

Angewandte Chemie, Volume 137, Issue 4, January 21, 2025.
The radiosynthesis of [18F]trifluoroiodomethane is described. CF218FI serves as building block for radical [18F]trifluoromethylation reactions in high molar activity, as exemplified by the Ru‐ and photoredox‐mediated synthesis of a range of 18F‐labeled α‐trifluoromethyl ketones and trifluoromethyl sulfides.
Lukas Veth, Albert D. Windhorst, Danielle J. Vugts   +2 more
wiley   +1 more source

Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography

Molecules, 2016
Reactive oxygen species (ROS) play important roles in cell signaling and homeostasis. However, an abnormally high level of ROS is toxic, and is implicated in a number of diseases.
Wenjie Zhang, Zhengxin Cai, Lin Li, Jim Ropchan, Keunpoong Lim, Nabil E. Boutagy, Jing Wu, John C. Stendahl, Wenhua Chu, Robert Gropler, Albert J. Sinusas, Chi Liu, Yiyun Huang   +12 more
doaj   +1 more source

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

EJNMMI Radiopharmacy and Chemistry
Background (S)-[18F]FETrp is a promising PET radiotracer for imaging IDO1 activity, one of the main enzymes involved in the tryptophan metabolism that plays a key role in several diseases including cancers.
Aurélie Maisonial-Besset, David Kryza, Klaus Kopka, Sophie Levesque, Emmanuel Moreau, Barbara Wenzel, Jean-Michel Chezal   +6 more
doaj   +1 more source

Automated GMP production and long‐term experience in radiosynthesis of CB₁ tracer [¹⁸F]FMPEP‐d₂ [PDF]

, 2020
Salla Lahdenpohja, Thomas H. Keller, Sarita Forsbäck, Tapio Viljanen, Esa Kokkomäki, Riikka V. Kivelä, Jörgen Bergman, Olof Solin, Anna K. Kirjavainen   +8 more
openalex   +1 more source

Optimization of automated radiosynthesis of gallium-68-labeled PSMA11 with two 68Ge/68Ga generators: fractional elution or prepurification? [PDF]

, 2023
Flore Durieux, Bérengère Dekyndt, Jean-François Legrand, Antoine Rogeau, Emmanuel Malek, Franck Semah, P. Odou   +6 more
openalex   +1 more source

Procedures for the GMP-Compliant Production and Quality Control of [18F]PSMA-1007: A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer

Pharmaceuticals, 2017
Radiolabeled tracers targeting the prostate-specific membrane antigen (PSMA) have become important radiopharmaceuticals for the PET-imaging of prostate cancer.
Jens Cardinale, René Martin, Yvonne Remde, Martin Schäfer, Antje Hienzsch, Sandra Hübner, Anna-Maria Zerges, Heike Marx, Ronny Hesse, Klaus Weber, Rene Smits, Alexander Hoepping, Marco Müller, Oliver C. Neels, Klaus Kopka   +14 more
doaj   +1 more source

Automated radiosynthesis of [89Zr]Zr-DFOSq-Durvalumab for imaging of PD-L1 expressing tumours in vivo.

Nuclear Medicine and Biology, 2023
C. Wichmann, Stan Poniger, N. Guo, P. Roselt, S. Rudd, P. Donnelly, B. Blyth, Jessica K Van Zuylekom, A. Rigopoulos, I. Burvenich, L. Morandeau, Shifaza Mohamed, A. Nowak, Fiona Hegi-Johnson, M. MacManus, A. Scott   +15 more
semanticscholar   +1 more source

Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP

EJNMMI Research
Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination.
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas   +9 more
doaj   +1 more source

Radiosynthesis and PET Bioimaging of 76Br-Bedaquiline in a Murine Model of Tuberculosis.

ACS Infectious Diseases, 2019
Bedaquiline is a promising drug against tuberculosis (TB), but limited data are available on its intralesional pharmacokinetics. Moreover, current techniques rely on invasive tissue resection, which is difficult in humans and generally limited even in ...
A. Ordonez, L. Carroll, S. Abhishek, F. Mota, Camilo A. Ruiz-Bedoya, Mariah H. Klunk, Alok K. Singh, Joel S. Freundlich, R. Mease, Sanjay K. Jain   +9 more
semanticscholar   +1 more source