Results 11 to 20 of about 10,067 (250)

Radiosynthesis of [¹⁸F]-Labelled Pro-Nucleotides (ProTides) [PDF]

Molecules, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success.
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell   +7 more
doaj   +7 more sources

Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist [PDF]

Molecules, 2015
In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. Desmethyl isradipine (4-(benzo[c][1,
Benjamin H. Rotstein, Steven H. Liang, Vasily V. Belov, Eli Livni, Dylan B. Levine, Ali A. Bonab, Mikhail I. Papisov, Roy H. Perlis, Neil Vasdev   +8 more
doaj   +2 more sources

Fully Automated, High-Dose Radiosynthesis of [¹⁸F]PARPi [PDF]

Pharmaceuticals, 2022
[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit ...
Anna Pacelli, Fadi Zarrad, Corentin Warnier, Thibault Gendron, Muhammad Otabashi, Charles Vriamont, Alex Jackson, Wolfgang P. Fendler, Ken Herrmann, Michael Nader   +9 more
doaj   +6 more sources

Efficient one-pot radiosynthesis of the 11C-labeled aquaporin-4 inhibitor TGN-020 [PDF]

EJNMMI Radiopharmacy and Chemistry
Background [11C]TGN-020 has been developed as a positron emission tomography (PET) tracer for imaging aquaporin-4 (AQP4) in the brain and used in clinical studies.
Kazunori Kawamura, Katsushi Kumata, Tomoteru Yamasaki, Masanao Ogawa, Yusuke Kurihara, Nobuki Nengaki, Yukimi Nakamura, Maiko Ono, Yuhei Takado, Hironaka Igarashi, Ming-Rong Zhang   +10 more
doaj   +2 more sources

Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene [PDF]

EJNMMI Radiopharmacy and Chemistry
Background In recent years, the development of the [18F]difluoromethyl radical ([18F]2-((difluoromethyl)sulfonyl)benzo[d]thiazole, [18F]4), and [18F]difluorocarbene ([18F]1-chloro-4-((difluoromethyl)sulfonyl)benzene, [18F]10) prosthetic groups, has paved
Catherine G. F. Dickmann, Andrew D. Bond, Selena Milicevic Sephton, Franklin I. Aigbirhio   +3 more
doaj   +2 more sources

Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP [PDF]

EJNMMI Research
Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination.
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas   +9 more
doaj   +2 more sources

Improved Automated Radiosynthesis of [11C]PBR28 [PDF]

Scientia Pharmaceutica, 2015
Microglial activation is commonly identified by elevated levels of the 18 kDa translocator protein (TSPO) in response to several inflammatory processes. [(11)C]PBR28 is one of the most promising PET tracers to image TSPO in both human and non-human primates.
Kiran Kumar Solingapuram Sai
openalex   +4 more sources

Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats [PDF]

Frontiers in Pharmacology
ObjectiveTo optimize the automated radiosynthesis of the purinergic ion channel receptor 7 (P2X7R) imaging agent 18F-JNJ64413739 and evaluate its potential for brain imaging in osteoporotic model rats.MethodsA more electron-deficient nitropyridine was ...
Yingtong Lu, Yan Cui, Lu Hou, Yuanfang Jiang, Jingjie Shang, Lu Wang, Hao Xu, Weijian Ye, Yang Qiu, Bin Guo   +9 more
doaj   +2 more sources

Radiosynthesis and evaluation of an ¹⁸F-labeled radioligand for imaging metabotropic glutamate receptor 3 with positron emission tomography. [PDF]

Am J Nucl Med Mol Imaging
Rong J, Zhao C, Chaudhary AF, Chen J, Li Y, Zhou X, Song Z, Sun Z, Gao Y, Feng S, Zhao T, Hu QL, Li C, Haider A, Patel J, Ran C, Yuan H, Liang SH.   +17 more
europepmc   +2 more sources

Automated Manufacturing of Carbon-11 Radiopharmaceuticals Using Cassette-Based Radiosynthesizers. [PDF]

J Labelled Comp Radiopharm
Carbon‐11 on cassette‐based radiosynthesis modules: Current state of the art. ABSTRACT As the field of radiochemistry moves toward the rapid development and translation of radiopharmaceuticals, the radiosynthetic methodology and manufacturing are becoming more and more refined.
Schulte ML, Rosenberg AJ.
europepmc   +2 more sources