Results 11 to 20 of about 7,738 (197)

Optimization of Automated Radiosynthesis of Gallium-68-Labeled PSMA11 with Two [⁶⁸Ge]Ge/[⁶⁸Ga]Ga Generators: Fractional Elution or Prepurification?

Pharmaceuticals, 2023
Prostate cancer is one of the most common forms of cancer in men. An imaging technique for its diagnosis is [68Ga]-prostate-specific membrane antigen ([68Ga]Ga-PSMA-11) positron emission tomography (PET).
Flore Durieux, Bérengère Dekyndt, Jean-François Legrand, Antoine Rogeau, Emmanuel Malek, Franck Semah, Pascal Odou   +6 more
doaj   +2 more sources

Targeting Fibroblast Activation Protein: Radiosynthesis and Preclinical Evaluation of an ¹⁸F-Labeled FAP Inhibitor [PDF]

Journal of Nuclear Medicine, 2020
Fibroblast activation protein (FAP) has emerged as an interesting molecular target used in the imaging and therapy of various types of cancers. 68Ga-labeled chelator-linked FAP inhibitors (FAPIs) have been successfully applied to PET imaging of various ...
Johannes Toms, Jürgen Kogler, Simone Maschauer, Christoph Daniel, Christian Schmidkonz, Torsten Kuwert, Olaf Prante   +6 more
openalex   +2 more sources

Radiosynthesis and evaluation of a fluorine-18 radiotracer [¹⁸F]FS1P1 for imaging sphingosine-1-phosphate receptor 1

Organic and biomolecular chemistry, 2021
Assessment of sphingosine-1-phosphate receptor 1 (S1PR1) expression could be a unique tool to determine the neuroinflammatory status for central nervous system (CNS) disorders. Our preclinical results indicate that PET imaging with [11C]CS1P1 radiotracer
Lin Qiu, Hao Jiang, Yanbo Yu, Jiwei Gu, Jinzhi Wang, Haiyang Zhao, Tianyu Huang, Robert J. Gropler, Robyn S. Klein, Joel S. Perlmutter, Zhude Tu   +10 more
openalex   +3 more sources

Radiosynthesis and Evaluation of Talazoparib and Its Derivatives as PARP-1-Targeting Agents [PDF]

Biomedicines, 2021
Poly (ADP-ribose) polymerase-1 (PARP-1) is a critical enzyme in the DNA repair process and the target of several FDA-approved inhibitors. Several of these inhibitors have been radiolabeled for non-invasive imaging of PARP-1 expression or targeted ...
Dong Zhou, Huaping Chen, Cedric Mpoy, Sadia Afrin, Buck E. Rogers, Joel R. Garbow, John A. Katzenellenbogen, Jinbin Xu   +7 more
openalex   +2 more sources

Automated Manufacturing of Carbon-11 Radiopharmaceuticals Using Cassette-Based Radiosynthesizers. [PDF]

J Labelled Comp Radiopharm
Carbon‐11 on cassette‐based radiosynthesis modules: Current state of the art. ABSTRACT As the field of radiochemistry moves toward the rapid development and translation of radiopharmaceuticals, the radiosynthetic methodology and manufacturing are becoming more and more refined.
Schulte ML, Rosenberg AJ.
europepmc   +2 more sources

Fully Automated Radiosynthesis of No-Carrier-Added [¹¹C]Butanol Using the GE FASTLab 2 Module. [PDF]

J Labelled Comp Radiopharm
Using the FASTLab 2, [11C]butanol was synthesized in 21 min with a radiochemical yield of 4%–8% (n = 3) and a radiochemical purity of > 90%. Synthesis on the FASTLab was fast, reliable, and comparable to legacy syntheses using TracerLab FX modules. ABSTRACT Radiolabeled alcohols have been investigated for their use in the measurement of cerebral blood ...
Wang IE, Witek JA, Pakula RJ, Henderson BD, Dakanali M, Shao X, Scott PJH.   +6 more
europepmc   +2 more sources

Radiosynthesis and characterization of [18F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism [PDF]

European Journal of Nuclear Medicine and Molecular Imaging, 2021
Translocator protein 18-kDa (TSPO) positron emission tomography (PET) is a valuable tool to detect neuroinflammed areas in a broad spectrum of neurodegenerative diseases.
Sang‐Hee Lee, Nunzio Denora, Valentino Laquintana, Giuseppe Felice Mangiatordi, Angela Lopedota, Antonio Lopalco, Annalisa Cutrignelli, Massimo Franco, Pietro Delre, In Ho Song, Hye Won Kim, Su Bin Kim, Hyun Soo Park, Kyungmin Kim, Seok‐Yong Lee, Hyewon Youn, Byung Chul Lee, Sang Eun Kim   +17 more
openalex   +2 more sources

Radiosynthesis, Stability, Lipophilicity, and Cellular Uptake Evaluations of [131I]Iodine-α-Mangostin for Breast Cancer Diagnosis and Therapy

International Journal of Molecular Sciences, 2023
The high rate of incidence and mortality caused by breast cancer encourage urgent research to immediately develop new diagnostic and therapeutic agents for breast cancer.
Wiwit Nurhidayah, E. M. Widyasari, I. Daruwati, Isa Mahendra, T. Subroto, Nur Kusaira Khairul Ikram, M. Muchtaridi   +6 more
semanticscholar   +1 more source

Automated Radiosynthesis of 1-(2-[18 F]Fluoroethyl)-L-Tryptophan ([18 F]FETrp) for PET Imaging of Cancer in Humans.

Journal of labelled compounds & radiopharmaceuticals, 2023
The radiotracer 1-(2-[18 F]fluoroethyl)-L-tryptophan (L-[18 F]FETrp or [18 F]FETrp) is a substrate of indoleamine 2,3-dioxygenase (IDO), the initial and key enzyme of the kynurenine pathway associated with tumoral immune resistance.
Huailei Jiang, Yan Guo, Hancheng Cai, Nerissa T. Viola, A. Shields, O. Muzik, C. Juhász   +6 more
semanticscholar   +1 more source

Detailed Radiosynthesis of [18 F]mG4P027 as a Positron Emission Tomography (PET) Radiotracer for mGluR4.

Journal of labelled compounds & radiopharmaceuticals, 2023
We report here the detailed radiosynthesis of [18 F]mG4P027, a metabotropic glutamate receptor 4 (mGluR4) PET radiotracer, which showed superior properties to the currently reported mGluR4 radiotracers. The radiosynthesis in the automated system has been
Junfeng Wang, Sung-Hyun Moon, Michael B. Cleary, T. Shoup, G. El Fakhri, Zhaoda Zhang, A. Brownell   +6 more
semanticscholar   +1 more source