Results 21 to 30 of about 7,738 (197)
International Journal of Molecular Sciences, 2023 We have established a method for nucleophilic one-pot, two-step radiosynthesis of the popular opioid receptor radioligand 6-O-(2-[18F]fluoroethyl)-6-O-desmethyl-diprenorphine ([18F]FE-DPN) from the novel precursor 6-O-(2-tosyloxyethyl)-6-O-desmethyl- 3-O-
Enikő Németh +8 more
semanticscholar +1 more source
Radiosynthesis and Evaluation of [<sup>18</sup>F]FEHSP990 as Novel PET Tracer for Hsp90 PET Imaging. [PDF]
J Labelled Comp Radiopharm[18F]FEHSP990 was successfully developed and preclinically evaluated as a novel Hsp90 PET brain probe for tumour and brain imaging. The probe demonstrated high and Hsp90‐specific binding to rodent brain and glioblastoma tumour tissue. In vivo, the tracer showed limited brain exposure, potentially due to insufficient affinity for Hsp90 and/or restricted
Cools R +4 more
europepmc +2 more sources
Radiosynthesis and Preclinical Evaluation of Bispecific PSMA/FAP Heterodimers for Tumor Imaging
Pharmaceuticals, 2022 Due to tumor heterogeneity and complex tumor–stromal interactions in multicellular systems, the efficiency of monospecific tracers for tumor diagnosis and therapy is currently limited. In light of the evidence of prostate-specific membrane antigen (PSMA)
Kongzhen Hu +9 more
semanticscholar +1 more source
Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis.
Journal of the American Chemical Society, 2021 The lack of efficient [18F]fluorination processes and target-specific organofluorine chemotypes remains the major challenge of fluorine-18 positron emission tomography (PET).
Qinheng Zheng +10 more
semanticscholar +1 more source
Atom Indonesia, 2022 Radiosynthesized silver nanoparticles (AgNPs) offer benefits for treatment of chronic colon inflammation due to their anti-inflammatory activity. Targeted delivery of AgNPs to the colon allows topical treatment at high concentration but at reduced ...
D. P. Perkasa, W. Arozal, M. Suhaeri
doaj +1 more source
An Optimized Radiosynthesis of [18 F]DK222, a PET Radiotracer for Imaging PD-L1.
Journal of labelled compounds & radiopharmaceuticals, 2023 A radiochemical synthesis of [18 F]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described and results from validation productions are presented. The high specific activity radiotracer product is prepared
D. Holt +3 more
semanticscholar +1 more source
Fully automated radiosynthesis of [18F]mG4P027 for mGluR4 imaging
iRADIOLOGY, 2023 Background Fluorine‐18 labeled N‐(4‐chloro‐3‐(((fluoro‐18F)methyl‐d2)thio)phenyl)picolinamide, [18F]mG4P027, is a potent positron emission tomography (PET) radiotracer for mGluR4.
Sung‐Hyun Moon +4 more
doaj +1 more source
SynOpen, 2022 Erianin is an active constituent of Dendrobium candidum. In this work, 18F-fluoroethoxylerianin ([18F]FEE), a 18F-Labeled erianin analogue, was designed and synthesized to evaluate the properties of erianin and related analogues by in vivo PET imaging ...
Hui Nie +7 more
doaj +1 more source
Chemical Reviews, 2022 The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development ...
A. Shegani +8 more
semanticscholar +1 more source
Optimization of the Automated Synthesis of [11C]mHED—Administered and Apparent Molar Activities
Pharmaceuticals, 2019 The tracer [[11C]meta-Hydroxyephedrine ([[11C]mHED) is one of the most applied PET tracers for cardiac imaging, whose radiosynthesis was already reported in 1990.
Chrysoula Vraka +13 more
doaj +1 more source