Results 21 to 30 of about 10,067 (250)

A Digital Revolution in Radiosynthesis [PDF]

Journal of Nuclear Medicine, 2013
The rapid growth in the use of PET has led to a concomitant demand in the availability of imaging tracers and research directed toward more efficient and flexible radiosynthetic routes. The production of multiple PET tracers presents a challenge to radiopharmaceutical production facilities;
David E. Reichert
openalex   +3 more sources

Automatic Production of [¹⁸F]F-DOPA Using the Raytest SynChrom R&D Module

Pharmaceuticals, 2022
[18F]F-DOPA is widely used in PET diagnostics. Diseases diagnosed with this tracer are schizophrenia, Parkinson’s disease, gliomas, neuroendocrine tumors, pheochromocytomas, and pancreatic adenocarcinoma.
Paweł Waśniowski, Jolanta Czuczejko, Michał Chuchra, Mateusz Wędrowski, Dawid Marciniak, Stanisław Sobiak, Bogdan Małkowski   +6 more
doaj   +1 more source

Production of [¹¹C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer

Molecules, 2022
In the last decade, microfluidic techniques have been explored in radiochemistry, and some of them have been implemented in preclinical production. However, these are not suitable and reliable for preparing different types of radiotracers or dose-on ...
Hemantha Mallapura, Laurent Tanguy, Bengt Långström, Ludovic Le Meunier, Christer Halldin, Sangram Nag   +5 more
doaj   +1 more source

Synthesis and Evaluation of Radioiodinated [¹²⁵I]7-Iodo-5H-Pyrido[4,3-B]Indole ([¹²⁵I]CTAU) in Postmortem Human Alzheimer's Disease Brain. [PDF]

J Labelled Comp Radiopharm
[125I]CTAU, a new analog of [18F]T807, was found to be suitable for imaging tau protein in postmortem human Alzheimer's disease brain slices. [125I]CTAU may be among the smaller ring structures that bind to tau protein. ABSTRACT The aim of this study was to further understand the tau imaging agent, flortaucipir (T807), by making small modifications and
McNamara CC, Biju AP, Hipolito ELM, Nguyen NTB, Liang C, Mukherjee J.   +5 more
europepmc   +2 more sources

Publisher Correction: On the automated radiosynthesis of pharmaceutical grade [⁶⁸Ga]Ga-Pentixafor, its pre-clinical evaluation, clinical application and radiation dosimetry aspects. [PDF]

Sci Rep
Menon SR, Sahu S, Mitra A, Chakraborty A, Malhotra G, Kamaldeep, Tawate M, Lad S, Rakshit S, Upadhye T, Ray MK, Banerjee S.   +11 more
europepmc   +3 more sources

Fully Automated Radiosynthesis of No-Carrier-Added [¹¹C]Butanol Using the GE FASTLab 2 Module. [PDF]

J Labelled Comp Radiopharm
Using the FASTLab 2, [11C]butanol was synthesized in 21 min with a radiochemical yield of 4%–8% (n = 3) and a radiochemical purity of > 90%. Synthesis on the FASTLab was fast, reliable, and comparable to legacy syntheses using TracerLab FX modules. ABSTRACT Radiolabeled alcohols have been investigated for their use in the measurement of cerebral blood ...
Wang IE, Witek JA, Pakula RJ, Henderson BD, Dakanali M, Shao X, Scott PJH.   +6 more
europepmc   +2 more sources

¹⁸F-Radiopharmaceutical Diversification Enabled by Deaminative Cross-Electrophile Couplings. [PDF]

Angew Chem Int Ed Engl
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Ogilvy IF, Ford J, Ortalli S, Renders E, Hayes TR, Liu S, Mortiers I, Nikolopoulou A, Sorlin AM, Trabanco AA, Tredwell M, Buijnsters PJJA, Salter R, Gouverneur V.   +13 more
europepmc   +2 more sources

Copper-Mediated Radiosynthesis of [¹⁸F]Rucaparib

Organic Letters, 2021
The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies to access the 18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic 18F-fluorodeboronation.
Chen, Z, Destro, G, Guibbal, F, Chan, CY, Cornelissen, B, Gouverneur, V   +5 more
openaire   +4 more sources

Radiosynthesis of antitumor spliceosome modulators [PDF]

Applied Radiation and Isotopes, 2011
A set of novel antitumor agents (the sudemycins) has recently been described that are analogs of the natural product FR901464. We report the radiosynthesis of two of these antitumor drug lead compounds, using a three step procedure: (1) ester hydrolysis, (2) Lindlar's catalyst/tritium gas to give a (S,Z)-4-acetoxypent-2-enoic acid derivative, and ...
Tinopiwa, Goronga, Vincent A, Boyd, Chandraiah, Lagisetti, Cynthia, Jeffries, Thomas R, Webb   +4 more
openaire   +2 more sources

Potentials of Alginates as Capping Agent for Oral Colon Delivery of Radiosynthesized Silver Nanoparticles: A Review

Atom Indonesia, 2022
Radiosynthesized silver nanoparticles (AgNPs) offer benefits for treatment of chronic colon inflammation due to their anti-inflammatory activity. Targeted delivery of AgNPs to the colon allows topical treatment at high concentration but at reduced ...
D. P. Perkasa, W. Arozal, M. Suhaeri
doaj   +1 more source