Results 31 to 40 of about 10,067 (250)

Radiosynthesis and evaluation of a carbon-11 labeled PET ligand for imaging of O-GlcNAcase. [PDF]

Am J Nucl Med Mol Imaging
Li Y, Zhou X, Song Z, Zhao T, Rong J, Chen J, Zhao C, Hu Q, Li X, Li C, Sun Z, Gao Y, Patel JS, Chaudhary A, Yuan H, Liang SH.   +15 more
europepmc   +2 more sources

Total Radiosynthesis: Thinking Outside ‘the Box' [PDF]

Australian Journal of Chemistry, 2015
The logic of total synthesis transformed a stagnant state of chemistry when there was a paucity of methods and reagents to synthesize pharmaceuticals. Molecular imaging by positron emission tomography (PET) is now experiencing a renaissance in the way radiopharmaceuticals are synthesized; however, a paradigm shift is desperately needed in the ...
Steven H, Liang, Neil, Vasdev
openaire   +2 more sources

Fully automated radiosynthesis of [18F]mG4P027 for mGluR4 imaging

iRADIOLOGY, 2023
Background Fluorine‐18 labeled N‐(4‐chloro‐3‐(((fluoro‐18F)methyl‐d2)thio)phenyl)picolinamide, [18F]mG4P027, is a potent positron emission tomography (PET) radiotracer for mGluR4.
Sung‐Hyun Moon, Georges El Fakhri, Zhaoda Zhang, Anna‐Liisa Brownell, Junfeng Wang   +4 more
doaj   +1 more source

Radiosynthesis and Tumor MicroPET/CT Imaging of 18F-Fluoro­ethoxylerianin, an 18F-Labeled Erianin Analogue

SynOpen, 2022
Erianin is an active constituent of Dendrobium candidum. In this work, 18F-fluoroethoxylerianin ([18F]FEE), a 18F-Labeled erianin analogue, was designed and synthesized to evaluate the properties of erianin and related analogues by in vivo PET imaging ...
Hui Nie, Nian Wang, Jinwen Huang, Zhuang Ni, Kangyan Xue, Lixing Song, Mingwei Wang, Fanhong Wu   +7 more
doaj   +1 more source

A one‐pot radiosynthesis of [¹⁸F]PARPi

Journal of Labelled Compounds and Radiopharmaceuticals, 2020
In this paper, we disclose a new strategy for the radiosynthesis of [18F]PARPi from the corresponding, boc‐protected, nitro‐precursor. Using a two‐step procedure, [18F]PARPi could be isolated in radiochemical yields up to 9.6%. The reaction proceeds via an efficient one‐pot, two‐step process, allowing for simplification over previous methods that ...
Thomas C. Wilson, Nagavarakishore Pillarsetty, Thomas Reiner   +2 more
openalex   +5 more sources

Optimization of the Automated Synthesis of [11C]mHED—Administered and Apparent Molar Activities

Pharmaceuticals, 2019
The tracer [[11C]meta-Hydroxyephedrine ([[11C]mHED) is one of the most applied PET tracers for cardiac imaging, whose radiosynthesis was already reported in 1990.
Chrysoula Vraka, Verena Pichler, Neydher Berroterán-Infante, Tim Wollenweber, Anna Pillinger, Maximilian Hohensinner, Lukas Fetty, Dietrich Beitzke, Xiang Li, Cecile Philippe, Katharina Pallitsch, Markus Mitterhauser, Marcus Hacker, Wolfgang Wadsak   +13 more
doaj   +1 more source

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources

Plug-and-play modules for flexible radiosynthesis [PDF]

Applied Radiation and Isotopes, 2013
We present a plug-and-play radiosynthesis platform and accompanying computer software based on modular subunits that can easily and flexibly be configured to implement a diverse range of radiosynthesis protocols. Modules were developed that perform: (i) reagent storage and delivery, (ii) evaporations and sealed reactions, and (iii) cartridge-based ...
Henry, Herman, Graciela, Flores, Kevin, Quinn, Mark, Eddings, Sebastian, Olma, Melissa D, Moore, Huijiang, Ding, Krzysztof P, Bobinski, Mingwei, Wang, Dirk, Williams, Darin, Wiliams, Clifton Kwang-Fu, Shen, Michael E, Phelps, R, Michael van Dam   +13 more
openaire   +2 more sources

One-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents [PDF]

, 2017
An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described.
Luthra, Sajinder K., McRobbie, Graeme, Pimlott, Sally L., Sloan, Nikki L., Sutherland, Andrew   +4 more
core   +2 more sources

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography [PDF]

, 2008
The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor ...
Bergstr  m, Burns, Chou, D. A. Harki, D. B. Stout, Dervan, Dervan, Dudouet, Edelson, Gross, Harapanhalli, Hsu, K  hnast, Lee, Lendvai, M. E. Phelps, N. Satyamurthy, P. B. Dervan, Phelps, Phelps, Poethko, Puckett, Roivainen, Schottelius, Tavitian, Toyokuni, Trauger   +26 more
core   +3 more sources