Results 31 to 40 of about 7,738 (197)
Pharmaceuticals, 2022 FAP-targeted radiopharmaceuticals represent a breakthrough in cancer imaging and a viable option for therapeutic applications. OncoFAP is an ultra-high-affinity ligand of FAP with a dissociation constant of 680 pM.
F. Bartoli +10 more
semanticscholar +1 more source
Radiosynthesis and Analysis of (S)-4-(3-[18F]Fluoropropyl)-L-Glutamic Acid
Molecular Imaging and Biology, 2022 Purpose ( S )-4-(3-[^18F]Fluoropropyl)-L-glutamic acid ([^18F]FSPG) is an L-glutamate derivative used as a PET biomarker to assess intracellular redox status in vivo through targeting of the cystine/glutamate antiporter protein, x_c^− transporter.
G. Brown, D. Soloviev, D. Lewis
semanticscholar +1 more source
Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer
EJNMMI Radiopharmacy and Chemistry, 2023 Background The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiolabelled with indium-111 (111In) or gallium-68 (68Ga).
Emma Jussing +10 more
doaj +1 more source
Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip. [PDF]
PLoS ONE, 2016 In the field of positron emission tomography (PET) radiochemistry, compact microreactors provide reliable and reproducible synthesis methods that reduce the use of expensive precursors for radiolabeling and make effective use of the limited space in a ...
Hiroyuki Kimura +10 more
doaj +1 more source
Molecules, 2015 In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. Desmethyl isradipine (4-(benzo[c][1,
Benjamin H. Rotstein +8 more
doaj +1 more source
EJNMMI Radiopharmacy and Chemistry, 2023 Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells.
Torsten Kniess +5 more
doaj +1 more source
Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide
EJNMMI Radiopharmacy and Chemistry, 2019 Background [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [11C]metoclopramide or other ...
Verena Pichler +6 more
doaj +1 more source
ACS Chemical Neuroscience, 2021 CBD-2115 was selected from a library of 148 compounds based on a pyridinyl-indole scaffold as a first-in-class 4R-tau radiotracer. In vitro binding assays showed [3H]CBD-2115 had a KD value of 6.9 nM and a nominal Bmax of 500 nM in 4R-tau expressing ...
Anton Lindberg +15 more
semanticscholar +1 more source
Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein
Applied Sciences, 2014 Two α-synuclein ligands, 3-methoxy-7-nitro-10H-phenothiazine (2a, Ki = 32.1 ± 1.3 nM) and 3-(2-fluoroethoxy)-7-nitro-10H-phenothiazine (2b, Ki = 49.0 ± 4.9 nM), were radiolabeled as potential PET imaging agents by respectively introducing 11C and 18F ...
Xiang Zhang +8 more
doaj +1 more source
Cerenkov Luminescence Imaging in the Development and Production of Radiopharmaceuticals
Frontiers in Physics, 2021 Over the past several years there has been an explosion of interest in exploiting Cerenkov radiation to enable in vivo and intraoperative optical imaging of subjects injected with trace amounts of radiopharmaceuticals.
R. Michael van Dam +3 more
doaj +1 more source