Results 41 to 50 of about 7,738 (197)

Novel late-stage radiosynthesis of 5-[18F]-trifluoromethyl-1,2,4-oxadiazole (TFMO) containing molecules for PET imaging

Scientific Reports, 2021
Small molecules that contain the (TFMO) moiety were reported to specifically inhibit the class-IIa histone deacetylases (HDACs), an important target in cancer and the disorders of the central nervous system (CNS).
N. Turkman, Daxing Liu, Isabella Pirola
semanticscholar   +1 more source

Copper-Mediated Radiosynthesis of [18F]Rucaparib.

Organic Letters, 2021
The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies to access the 18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic 18F-fluorodeboronation.
Zijun Chen, Gianluca Destro, Florian Guibbal, C. Chan, B. Cornelissen, V. Gouverneur   +5 more
semanticscholar   +1 more source

[¹⁸F]Trifluoroiodomethane - Enabling Photoredox-mediated Radical [¹⁸F]Trifluoromethylation for Positron Emission Tomography. [PDF]

Angew Chem Int Ed Engl
The radiosynthesis of [18F]trifluoroiodomethane is described. CF218FI serves as building block for radical [18F]trifluoromethylation reactions in high molar activity, as exemplified by the Ru‐ and photoredox‐mediated synthesis of a range of 18F‐labeled α‐trifluoromethyl ketones and trifluoromethyl sulfides.
Veth L, Windhorst AD, Vugts DJ.
europepmc   +2 more sources

Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA

EJNMMI Radiopharmacy and Chemistry, 2021
The neurotracer 6-[18F] FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies.
Ângela C. B. Neves, Ivanna Hrynchak, Inês Fonseca, Vítor H. P. Alves, Mariette M. Pereira, Amílcar Falcão, Antero J. Abrunhosa   +6 more
doaj   +1 more source

Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression

Molecules, 2013
With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3 ...
Simon M. Ametamey, Silvana Raić-Malić, Stjepko Čermak, Roger Slavik, Adrienne Müller, Thomas Betzel, Andrijana Meščić   +6 more
doaj   +1 more source

GMP-compliant fully automated radiosynthesis of [18F]FEPPA for PET/MRI imaging of regional brain TSPO expression

EJNMMI Research, 2021
Background Expression of translocator protein (TSPO) on the outer mitochondrial membrane of activated microglia is strongly associated with neuroinflammation.
Chi-Wei Chang, Chuang-Hsin Chiu, Ming-Hsien Lin, Hung-Ming Wu, Tsung-Hsun Yu, Pao-Yeh Wang, Yu-Yeh Kuo, Ya-Yao Huang, C. Shiue, Wen-Sheng Huang, S. Yeh   +10 more
semanticscholar   +1 more source

Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide

Molecules, 2011
4-[18F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[18F]fluorophenoxy moiety. In order to prepare 4-[18F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method ...
Tobias L. Ross, Johannes Ermert, Heinz H. Coenen   +2 more
doaj   +1 more source

Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry

Scientific Reports, 2022
The increasing number of positron-emission tomography (PET) tracers being developed to aid drug development and create new diagnostics has led to an increased need for radiosynthesis development and optimization.
Alejandra Rios, Travis S. Holloway, Philip H. Chao, Christian De Caro, Chelsea C. Okoro, R. Michael van Dam   +5 more
doaj   +1 more source

Gamma Radiosynthesis of Colloidal Silver Nanoparticles Stabilized in ι-Carrageenan Under Atmospheric Gases: A Surface Plasmon Resonance Based Study

Atom Indonesia, 2021
ι-Carrageenan is a biodegradable and biocompatible biomaterial which potentially stabilizes colloidal silver nanoparticles (AgNPs). The present study explored gamma radiosynthesis of AgNPs at varied concentration of ι-carrageenan solutions.
D. P. Perkasa, M. Y. Yunus, Y. Warastuti, B. Abbas   +3 more
doaj   +1 more source

Automated radiosynthesis of [11C]CPPC for in-human PET imaging applications.

American Journal of Nuclear Medicine and Molecular Imaging
The macrophage colony-stimulating factor 1 receptor (CSF1R) is almost exclusively expressed in microglia, representing a biomarker target for imaging of microglia availability.
Huailei Jiang, Pritam Roy, Yan Guo, Otto Muzik, Eric A Woodcock   +4 more
semanticscholar   +1 more source