Results 41 to 50 of about 10,067 (250)
Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer
EJNMMI Radiopharmacy and Chemistry, 2023 Background The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiolabelled with indium-111 (111In) or gallium-68 (68Ga).
Emma Jussing +10 more
doaj +1 more source
Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates [PDF]
, 2016 Phosphodiesterase 10A (PDE10A) inhibitors show therapeutic effects for diseases with striatal pathology. PET radiotracers have been developed to quantify in vivo PDE10A levels and target engagement for therapeutic interventions. The aim of this study was
Alagille, David +10 more
core +2 more sources
Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. [PDF]
, 2017 Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes
Blecha, Joseph E +10 more
core +1 more source
Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip. [PDF]
PLoS ONE, 2016 In the field of positron emission tomography (PET) radiochemistry, compact microreactors provide reliable and reproducible synthesis methods that reduce the use of expensive precursors for radiolabeling and make effective use of the limited space in a ...
Hiroyuki Kimura +10 more
doaj +1 more source
Automated radiosynthesis of Al[18F]PSMA-11 for large scale routine use. [PDF]
, 2018 Objectives: We report a reproducible automated radiosynthesis for large scale batch production of clinical grade Al[F-18]PSMA-11. Methods: A SynthraFCHOL module was optimized to synthesize Al[F-18]PSMA-11 by Al[F-18]-chelation.
Brans, Boudewijn +7 more
core +1 more source
Photocatalyzed radiosynthesis of 11C‐phenylacetic acids
Journal of Labelled Compounds and Radiopharmaceuticals, 2023 Fast and straightforward incorporation of radionuclides into pharmaceutically relevant molecules is one of the main barriers to preclinical and clinical tracer research. Late‐stage direct incorporation of cyclotron‐produced [11C]CO2 to afford carbon‐11‐labeled radiopharmaceuticals has the potential to provide ready‐to‐inject positron emission ...
Maxime Munch +3 more
openaire +2 more sources
EJNMMI Radiopharmacy and Chemistry, 2023 Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells.
Torsten Kniess +5 more
doaj +1 more source
Pharmaceuticals, 2023 Prostate cancer is one of the most common forms of cancer in men. An imaging technique for its diagnosis is [68Ga]-prostate-specific membrane antigen ([68Ga]Ga-PSMA-11) positron emission tomography (PET).
Flore Durieux +6 more
doaj +1 more source
Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide
EJNMMI Radiopharmacy and Chemistry, 2019 Background [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [11C]metoclopramide or other ...
Verena Pichler +6 more
doaj +1 more source
Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering [PDF]
, 2016 Transplantation of human muscle precursor cells (hMPCs) is envisioned for the treatment of various muscle diseases. However, a feasible noninvasive tool to monitor cell survival, migration, and integration into the host tissue is still missing. METHODS:
Ametamey, Simon M. +10 more
core +2 more sources