Results 51 to 60 of about 7,738 (197)

Automated Radiosynthesis, Quality Control, and Biodistribution of Ga-68 Pentixafor: First Indian Experience

Indian Journal of Nuclear Medicine, 2021
Background: Chemokine receptor CXCR4 is overexpressed in more than 27 different human tumors that make it a promising target in oncology. Ga-68 Pentixafor is the most promising positron emission tomography tracer for imaging CXCR4 receptors; hence, the ...
Ankit Watts, Surbhi Chutani, Diksha Arora, Vasanth Madivanane, Samiksha Thakur, Monika Kamboj, Baljinder Singh   +6 more
semanticscholar   +1 more source

Automated Radiosynthesis of cis- and trans-4-[18F]Fluoro-l-proline Using [18F]Fluoride

Journal of Organic Chemistry, 2021
The positron emission tomography imaging agents cis- and trans-4-[18F]fluoro-l-proline are used for the detection of numerous diseases such as pulmonary fibrosis and various carcinomas.
Timaeus E F Morgan, Leanne M Riley, A. Tavares, Andrew V. Sutherland   +3 more
semanticscholar   +1 more source

A closer look at the synthesis of 2-[18F]fluoroethyl tosylate to minimize the formation of volatile side-products

EJNMMI Radiopharmacy and Chemistry, 2022
Background 2-[18F]Fluoroethyltosylate ([18F]FEtOTs) is a well-known 18F-fluoroalkylating agent widely used to synthesize radiotracers for positron emission tomography.
Martha Sahylí Ortega Pijeira, Sofia Nascimento dos Santos, Yasniel Babi Araujo, André Luis Lapolli, Marcio Nardelli Wandermuren, Zalua Rodríguez Riera, Ivone Carvalho, Philip H. Elsinga, Emerson Soares Bernardes   +8 more
doaj   +1 more source

Radiosynthesis of a novel antisense imaging probe targeting LncRNA HOTAIR in malignant glioma

BMC Cancer, 2021
Long non-coding RNA (LncRNA) HOTAIR was amplified and overexpressed in many human carcinomas, which could serve as a useful target for cancer early detection and treatment.
Jiongyu Ren, Xiyuan Zhang, Jiang Cao, Jia-He Tian, Jin Luo, Yaping Yu, Fengkui Wang, Qian Zhao   +7 more
semanticscholar   +1 more source

Radiosynthesis of [11C]Ibrutinib via Pd-Mediated [11C]CO Carbonylation: Preliminary PET Imaging in Experimental Autoimmune Encephalomyelitis Mice

Frontiers in Nuclear Medicine, 2021
Ibrutinib is a first-generation Bruton's tyrosine kinase (BTK) inhibitor that has shown efficacy in autoimmune diseases and has consequently been developed as a positron emission tomography (PET) radiotracer.
Anton Lindberg, A. Boyle, J. Tong, Michael B. Harkness, Armando Garcia, Tritin Tran, Dongxu Zhai, Fang Liu, D. Donnelly, N. Vasdev   +9 more
semanticscholar   +1 more source

On the automated radiosynthesis of pharmaceutical grade [⁶⁸Ga]Ga-Pentixafor, its pre-clinical evaluation, clinical application and radiation dosimetry aspects. [PDF]

Sci Rep
Menon SR, Sahu S, Mitra A, Chakraborty A, Malhotra G, Kamaldeep, Tawate M, Lad S, Rakshit S, Upadhye T, Ray MK, Banerjee S.   +11 more
europepmc   +3 more sources

Multicenter Experience with Good Manufacturing Practice Production of [¹¹C]PiB for Amyloid Positron Emission Tomography Imaging

Pharmaceuticals
Alzheimer’s disease (AD) is a neurodegenerative disorder with increasing global prevalence and accounts for over half of all dementia cases. Early diagnosis is paramount for not only the management of the disease, but also for the development of new AD ...
Anders Bruhn Arndal Andersen, Szabolcs Lehel, Ebbe Klit Grove, Niels Langkjaer, Dan Fuglø, Tri Hien Viet Huynh   +5 more
doaj   +1 more source

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of 18F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3

ChemMedChem, EarlyView.
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda, Maxwell A. Boateng, Melinda Wuest, Frederick G. West, Frank Wuest   +4 more
wiley   +1 more source

Advancements in Microfluidic Cassette-Based iMiDEV™ Technology for Production of L-[¹¹C]Methionine and [¹¹C]Choline

Pharmaceuticals
Microfluidic technology is a highly efficient technique used in positron emission tomography (PET) radiochemical synthesis. This approach enables the precise control of reactant flows and reaction conditions, leading to improved yields and reduced ...
Hemantha Mallapura, Laurent Tanguy, Samin Mahfuz, Lovisa Bylund, Bengt Långström, Christer Halldin, Sangram Nag   +6 more
doaj   +1 more source

[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model

Molecules, 2018
[18F]FEPPA is a specific ligand for the translocator protein of 18 kDa (TSPO) used as a positron emission tomography (PET) biomarker for glial activation and neuroinflammation.
Nicolas Vignal, Salvatore Cisternino, Nathalie Rizzo-Padoin, Carine San, Fortune Hontonnou, Thibaut Gelé, Xavier Declèves, Laure Sarda-Mantel, Benoît Hosten   +8 more
doaj   +1 more source