Results 61 to 70 of about 7,738 (197)

Fully automated 18F-fluorination of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) for indirect labelling of nanobodies

Scientific Reports, 2022
N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB), a widely used labeling agent to introduce the 4-[18F]fluorobenzoyl-prosthetic group, is normally obtained in three consecutive steps from [18F]fluoride ion. Here, we describe an efficient one-step labeling
Surasa Nagachinta, Paolo Novelli, Yoann Joyard, Nicolas Maindron, Patrick Riss, Sylvestre Dammicco   +5 more
doaj   +1 more source

Radiosynthesis and Biological Evaluation of [18F]R91150, a Selective 5-HT2A Receptor Antagonist for PET-Imaging.

ACS Medicinal Chemistry Letters, 2021
Serotonergic 5-HT2A receptors in cortical and forebrain regions are an important substrate for the neuromodulatory actions of serotonin in the brain. They have been implicated in the etiology of many neuropsychiatric disorders and serve as a target for ...
M. Willmann, Julian Hegger, B. Neumaier, J. Ermert   +3 more
semanticscholar   +1 more source

Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth   +5 more
wiley   +1 more source

Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor. [PDF]

PLoS ONE, 2017
New radiochemistry techniques can yield novel PET tracers for COX-2 and address the shortcomings in in vivo stability and specificity, which have held back clinical translation of tracers to image COX-2 expression. Current techniques limit radiosynthesis
Artem Lebedev, Jing Jiao, Jason Lee, Fan Yang, Nathanael Allison, Harvey Herschman, Saman Sadeghi   +6 more
doaj   +1 more source

An Unexpected Facet of Extremophiles: Their Aesthetic Potential in Artistic Expression

Microbial Biotechnology, Volume 18, Issue 10, October 2025.
In an era marked by environmental challenges and the proliferation of misinformation, the fusion of art and science is a strategy to promote public understanding and appreciation of complex scientific phenomena. We illustrate how the use of extremophiles offers novel avenues for artistic exploration and emphasise the benefits of such interdisciplinary ...
Luis Andrés Yarzábal Rodríguez, Lenys M. Buela Salazar, Yordanis Pérez‐Llano, Nina Gunde‐Cimerman, Ramón Alberto Batista‐García   +4 more
wiley   +1 more source

A Fully Automated Synthesis of 14-(R,S)-[¹⁸F]fluoro-6-thia-heptadecanoic Acid ([¹⁸F]FTHA) on the Elixys Radiosynthesizer

Pharmaceuticals
14-(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA) is a radiocompound for imaging the fatty acid circulation by positron emission tomography.
Usevalad Ustsinau, Lukas Nics, Marcus Hacker, Cecile Philippe   +3 more
doaj   +1 more source

Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain

Pharmaceuticals, 2022
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitors ...
Oliver Clauß, Linda Schäker-Hübner, Barbara Wenzel, Magali Toussaint, Winnie Deuther-Conrad, Daniel Gündel, Rodrigo Teodoro, Sladjana Dukić-Stefanović, Friedrich-Alexander Ludwig, Klaus Kopka, Peter Brust, Finn K. Hansen, Matthias Scheunemann   +12 more
doaj   +1 more source

Exploration of Fluorinated Pyrazolidine‐3,5‐Diones for Positron Emission Tomography Imaging of the P2Y12 Receptor in the Central Nervous System

ChemMedChem, Volume 20, Issue 17, September 11, 2025.
Fluorinated pyrazolidine‐3,5‐dione derivatives are developed with the aim to find a positron emission tomography (PET) tracer candidate for imaging of the P2Y12 receptor. All compounds show nanomolar affinity. One compound is radiolabeled with 18F and used in PET imaging studies, revealing rapid metabolism and limited brain uptake.
E. Johanna L. Stéen, Anne van der Schatte Olivier, Berend van der Wildt, Pedro Pereira, Khaled Alkayal, Leopoldo J. Gabella Carena, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Barbara A. Zarzycka, Iwan J. P. de Esch, Albert D. Windhorst   +11 more
wiley   +1 more source

Radiosynthesis of [¹⁸F]-Labelled Pro-Nucleotides (ProTides)

Molecules, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success.
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell   +7 more
doaj   +1 more source

One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

EJNMMI Radiopharmacy and Chemistry, 2021
Background Fibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [18F]AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for FAP, which has already shown high accumulation within human tumors ...
Sadahiro Naka, Tadashi Watabe, Thomas Lindner, Jens Cardinale, Kenta Kurimoto, Melissa Moore, Mitsuaki Tatsumi, Yuriko Mori, Eku Shimosegawa, Frank Valla, Hiroki Kato, Frederik L. Giesel   +11 more
doaj   +1 more source