Results 61 to 70 of about 10,067 (250)

Gamma Radiosynthesis of Colloidal Silver Nanoparticles Stabilized in ι-Carrageenan Under Atmospheric Gases: A Surface Plasmon Resonance Based Study

Atom Indonesia, 2021
ι-Carrageenan is a biodegradable and biocompatible biomaterial which potentially stabilizes colloidal silver nanoparticles (AgNPs). The present study explored gamma radiosynthesis of AgNPs at varied concentration of ι-carrageenan solutions.
D. P. Perkasa, M. Y. Yunus, Y. Warastuti, B. Abbas   +3 more
doaj   +1 more source

Flow optimization study of a batch microfluidics PET tracer synthesizing device. [PDF]

, 2010
We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers.
Daridon, Antoine, Elizarov, Arkadij M, Heath, James R, Huang, Jiang, Kolb, Hartmuth C, Meinhart, Carl, Miraghaie, Reza, van Dam, R Michael   +7 more
core   +4 more sources

A closer look at the synthesis of 2-[18F]fluoroethyl tosylate to minimize the formation of volatile side-products

EJNMMI Radiopharmacy and Chemistry, 2022
Background 2-[18F]Fluoroethyltosylate ([18F]FEtOTs) is a well-known 18F-fluoroalkylating agent widely used to synthesize radiotracers for positron emission tomography.
Martha Sahylí Ortega Pijeira, Sofia Nascimento dos Santos, Yasniel Babi Araujo, André Luis Lapolli, Marcio Nardelli Wandermuren, Zalua Rodríguez Riera, Ivone Carvalho, Philip H. Elsinga, Emerson Soares Bernardes   +8 more
doaj   +1 more source

τBu₂SiF-Derivatized D₂-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging [PDF]

, 2011
The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D-2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron ...
Bartenstein, Peter, Höfner, Georg, Iovkova-Berends, Ljuba, Jurkschat, Klaus, Kostikov, Alexey, Rensch, Christian, Schirrmacher, Ralf, Wanner, Klaus Theodor, Wängler, Björn, Wängler, Carmen, Zöller, Thomas   +10 more
core   +2 more sources

Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole [PDF]

Journal of Radioanalytical and Nuclear Chemistry, 2018
N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research.
Kadirvel, Manikandan, Cardoso, Déborah, Freeman, Sally, Brown, Gavin   +3 more
openaire   +4 more sources

Synthesis of carbon-11-labeled isonicotinamides as new potential PET agents for imaging of GSK-3 enzyme in Alzheimer’s disease [PDF]

, 2017
The authentic standards 2-(cyclopropanecarboxamido)-N-(4-methoxypyridin-3-yl)isonicotinamide (4a) and 2-(cyclopropanecarboxamido)-N-(4-(4-methoxyphenyl)pyridin-3-yl)isonicotinamide (7a), and their corresponding precursors 2-(cyclopropanecarboxamido)-N-(4-
Gao, Mingzhang, Wang, Min, Zheng, Qi-Huang   +2 more
core   +2 more sources

Synthesis of carbon-11-labeled CK1 inhibitors as new potential PET radiotracers for imaging of Alzheimer’s disease [PDF]

, 2018
The reference standards methyl 3-((2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)carbamoyl)benzoate (5a) and N-(2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)-3-methoxybenzamide (5c), and their corresponding ...
Gao, Mingzhang, Wang, Min, Zheng, Qi-Huang   +2 more
core   +2 more sources

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine

, 2020
INTRODUCTION: Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis.
Baguet, Tristan, Beyzavi, M. Hassan, De Lombaerde, Stef, De Vos, Filip, Descamps, Benedicte, Donche, Sam, Goethals, Ingeborg, Hu, Jiyun, Lambe, Patricia, Pauwelyn, Glenn, Piron, Sarah, Vanhove, Christian, Verhoeven, Jeroen   +12 more
core   +1 more source

Evaluating hepatobiliary transport with 18F-labeled bile acids : the effect of radiolabel position and bile acid structure on radiosynthesis and in vitro and in vivo performance [PDF]

, 2018
Introduction. An in vivo determination of bile acid hepatobiliary transport efficiency can be of use in liver disease and preclinical drug development.
De Lombaerde, Stef, De Vos, Filip, Kersemans, Ken, Neyt, Sara, Vanhove, Christian, Verhoeven, Jeroen   +5 more
core   +3 more sources

Multicenter Experience with Good Manufacturing Practice Production of [¹¹C]PiB for Amyloid Positron Emission Tomography Imaging

Pharmaceuticals
Alzheimer’s disease (AD) is a neurodegenerative disorder with increasing global prevalence and accounts for over half of all dementia cases. Early diagnosis is paramount for not only the management of the disease, but also for the development of new AD ...
Anders Bruhn Arndal Andersen, Szabolcs Lehel, Ebbe Klit Grove, Niels Langkjaer, Dan Fuglø, Tri Hien Viet Huynh   +5 more
doaj   +1 more source