Results 71 to 80 of about 10,067 (250)
Assessment of labelled products with different radioanalytical methods: study on 18F-fluorination reaction of 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinyl-benzamide (p-[18F]MPPF) [PDF]
, 2010 Peer ...
Bergström, Kim +6 more
core +1 more source
European Journal of Organic Chemistry, EarlyView.This study exploits the comparable binding tolerances between the fluorinase enzyme and the A2A adenosine receptor towards the development of novel C‐2 functionalised 5′‐fluorodeoxy‐adenosine (FDA)‐based agonists with enzymatic 18F‐labelling capability for positron emission tomography (PET).
Nicolas Charalambous +6 more
wiley +1 more source
PharmaceuticalsMicrofluidic technology is a highly efficient technique used in positron emission tomography (PET) radiochemical synthesis. This approach enables the precise control of reactant flows and reaction conditions, leading to improved yields and reduced ...
Hemantha Mallapura +6 more
doaj +1 more source
Molecules, 2018 [18F]FEPPA is a specific ligand for the translocator protein of 18 kDa (TSPO) used as a positron emission tomography (PET) biomarker for glial activation and neuroinflammation.
Nicolas Vignal +8 more
doaj +1 more source
Scientific Reports, 2022 N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB), a widely used labeling agent to introduce the 4-[18F]fluorobenzoyl-prosthetic group, is normally obtained in three consecutive steps from [18F]fluoride ion. Here, we describe an efficient one-step labeling
Surasa Nagachinta +5 more
doaj +1 more source
Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor [PDF]
, 2017 P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer’s disease. This study reports the first design, synthesis, radiolabeling and biological evaluation
Gao, Mingzhang +7 more
core +2 more sources
Automated radiosynthesis of [11C]morphine for clinical investigation [PDF]
Applied Radiation and Isotopes, 2011 To meet a multiple-dose clinical evaluation of the P-gp modulation of [(11)C]morphine delivery into the human brain, radiosynthesis of [(11)C]morphine was accomplished on an automated system by N-methylation of normorphine with [(11)C]CH(3)I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed.
Jinda, Fan +6 more
openaire +2 more sources
European Journal of Organic Chemistry, Volume 29, Issue 4, January 26, 2026.Togni reagent I, one of the most used electrophilic trifluoromethylating reagents, has been radiolabeled with fluorine‐18 starting from the widely available fluoro‐benziodoxole and the [18F]Ruppert–Prakash reagent. To demonstrate the broad potential for late‐stage functionalization, aliphatic carboxylic acids were successfully converted into their 18F ...
Lizeth Y. F. Haveman +2 more
wiley +1 more source
Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor. [PDF]
PLoS ONE, 2017 New radiochemistry techniques can yield novel PET tracers for COX-2 and address the shortcomings in in vivo stability and specificity, which have held back clinical translation of tracers to image COX-2 expression. Current techniques limit radiosynthesis
Artem Lebedev +6 more
doaj +1 more source
Pharmaceuticals, 2022 The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitors ...
Oliver Clauß +12 more
doaj +1 more source