Results 71 to 80 of about 7,738 (197)
Pharmaceuticals, 2022 [68Ga]Ga-PSMA-11 PET/CT plays a pivotal role in the diagnosis and staging of prostate cancer because of its higher sensitivity and detection rate compared with traditional choline PET/CT.
Antonella Iudicello +4 more
doaj +1 more source
Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases
Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.Abstract Microtubules (MTs) are essential components of the neuronal cytoskeleton, playing key roles in intracellular transport, synaptic function, and overall neuronal integrity. Although MT dynamics and MT‐binding agents have been studied extensively, their potential as biomarkers in neurodegenerative diseases has received limited attention. Emerging
Naresh Damuka +2 more
wiley +1 more source
MoleculesThe aim of this study was to measure the brain penetrance and kinetics of BIIB104, a first-in-class AMPA receptor potentiator developed for cognitive impairment associated with schizophrenia.
Sangram Nag +9 more
doaj +1 more source
Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2018 Objective(s): Phenytoin is an antiepileptic drug that is used worldwide.The whole-body pharmacokinetics of this drug have been extensivelystudied using 11C-phenytoin in small animals.
Yasukazu Kanai +2 more
doaj +1 more source
Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine
Pharmaceuticals, 2023 The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications.
Jason Beaufrez +3 more
doaj +1 more source
Advanced NanoBiomed Research, Volume 5, Issue 9, September 2025.A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He +6 more
wiley +1 more source
Automated radiosynthesis and in vivo evaluation of 18F-labeled analog of the photosensitizer ADPM06 for planning photodynamic therapy [PDF]
, 2023 Kazunori Kawamura +10 more
openalex +1 more source
Ionic Liquid Aided [11C]CO Fixation for Synthesis of 11C‐carbonyls
ChemistryOpen, Volume 14, Issue 7, July 2025.Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid used in a proof‐of‐concept study evaluating its utility to trap carbon‐11 (t1/2=20.4 min)‐labeled CO for preparation of amides, ureas and carbamates. Abstract Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid developed to capture CO and has shown ...
Anton Lindberg +5 more
wiley +1 more source
Advanced Science, Volume 12, Issue 21, June 5, 2025.Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai +12 more
wiley +1 more source
Production Of 11C‐Labeled Amides Via “In‐Loop” 11C‐Carbonylation
Asian Journal of Organic Chemistry, Volume 14, Issue 6, June 2025.The current work utilizes carbon‐11 labelled aroyl dimethylaminopyridinium salts in a two‐step in‐loop carbonylative cross‐coupling reaction of aryl halides with [¹¹C]CO yielding a diverse range of carbon‐11 labelled primary benzamides with good to excellent yields.
Tanpreet Kaur +3 more
wiley +1 more source