Results 81 to 90 of about 7,738 (197)

Radiosynthesis and evaluation of a 68Ga‐labeled brominated benzamide derivative for detection of melanoma in small animals

Bulletin of the Korean Chemical Society, Volume 46, Issue 5, Page 540-546, May 2025.
Malignant melanoma has the highest mortality rate among skin cancers due to its aggressiveness and metastatic potential, and early diagnosis is important because treatment options are limited. We synthesized a brominated benzamide derivative labeled with 68Ga and evaluated its biological properties as a PET imaging probe.
Dagyeong Hong, Chaewon Lee, Boreum Song, Eunsu Kim, Yejin Seo, Jiyu Kim, Wookyeong Jeong, Seong‐Young Kwon, Dong‐Yeon Kim, Ayoung Pyo   +9 more
wiley   +1 more source

Development of a versatile [68Ga]Ga-FAPI-46 automated synthesis suitable to multi-elutions of germanium-68/gallium-68 generators

Frontiers in Chemistry
Gallium-68-labeled FAPI-46 has recently been proposed as a novel positron emission tomography imaging probe to diagnose and monitor a wide variety of cancers.
Louis-Paul Paty, Simon Degueldre, Claire Provost, Claire Provost, Camille Schmitt, Laura Trump, Laura Trump, Julien Fouque, Julien Fouque, Charles Vriamont, Frank Valla, Thibault Gendron, Olivier Madar, Olivier Madar   +13 more
doaj   +1 more source

Fully automated radiosynthesis of [18F]LBT999 on TRACERlab FXFN and AllinOne modules, a PET radiopharmaceutical for imaging the dopamine transporter in human brain

EJNMMI Radiopharmacy and Chemistry, 2020
Background Fluorine labelled 8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid methyl ester ([18F]LBT999) is a selective radioligand for the in vivo neuroimaging and quantification of the dopamine transporter by ...
Christine Vala, Céline Mothes, Gabrielle Chicheri, Pauline Magadur, Gilles Viot, Jean-Bernard Deloye, Serge Maia, Yann Bouvet, Anne-Claire Dupont, Nicolas Arlicot, Denis Guilloteau, Patrick Emond, Johnny Vercouillie   +12 more
doaj   +1 more source

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes

Molecules, 2013
The polymer supported phosphazene bases PS-P2tBu and the novel PS-P2PEG allowed for efficient extraction of [18F]F− from proton irradiated [18O]H2O and subsequent radiofluorination of a broad range of substrates directly on the resin.
Bente Mathiessen, Fedor Zhuravlev
doaj   +1 more source

Design and Synthesis of a Sialic Acid‐Derived Tracer for 18F‐PET Multiple Sclerosis Imaging

European Journal of Organic Chemistry, Volume 28, Issue 9, March 3, 2025.
To contribute to the growing interest in developing selective MS imaging agents, an 18F‐modified sialic acid‐based PET‐tracer candidate with high affinity towards myelin‐associated glycoprotein (MAG) is disclosed. A multi‐step synthesis of the tracer is disclosed, together preliminary validation of the radio‐labeling process.
Kathrin Siebold, Lea Göbel, Christian Paul Konken, Andreas Faust, Ryan Gilmour   +4 more
wiley   +1 more source

Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A) [PDF]

, 2022
Barbara Wenzel, Stefan R. Fritzsche, Magali Toussaint, Detlef Briel, Klaus Kopka, Peter Brust, Matthias Scheunemann, Winnie Deuther‐Conrad   +7 more
openalex   +1 more source

Comparing the Diagnostic Performance of [18F]PSMA‐1007 With [68Ga]Ga‐PSMA‐11 in PET/CT Imaging and Staging of Recurrent Prostate Cancer

Medicine Advances, Volume 3, Issue 1, Page 9-19, March 2025.
18F‐PSMA‐1007 and 68Ga‐PSMA‐11 demonstrated comparable diagnostic performance in detecting recurrent prostate cancer, with 18F‐PSMA‐1007 showing slightly higher sensitivity. Furthermore, 18F‐PSMA‐1007 offers advantages in cost‐effectiveness and availability, making it a potentially valuable alternative in clinical settings.
Negar Abdi, Miad Alsulami, Hamid Ghaznavi   +2 more
wiley   +1 more source

Automated radiosynthesis of [11C]UCB‐J for imaging synaptic density by positron emission tomography

Journal of labelled compounds & radiopharmaceuticals, 2020
An automated radiosynthesis of carbon‐11 positron emission tomography radiotracer [11C]UCB‐J for imaging the synaptic density biomarker synaptic vesicle glycoprotein SV2A was established using Synthra RNPlus synthesizer.
S. Milicevic Sephton, Tünde Miklovicz, Joseph J Russell, A. Doke, Lei Li, I. Boros, F. Aigbirhio   +6 more
semanticscholar   +1 more source

Synthesis and characterisation of DOTA‐kisspeptin‐10 as a potential gallium‐68/lutetium‐177 pan‐tumour radiopharmaceutical

Journal of Neuroendocrinology, Volume 37, Issue 3, March 2025.
DOTA‐kisspeptin‐10, labelled with gallium‐68 and lutetium‐177, is presented for as a possible pan‐tumour radiopharmaceutical. The modified peptide retains biological activity at the KISS1 receptor, demonstrates good stability and exhibits rapid blood clearance, supporting its potential for cancer detection and therapy in future theranostic applications.
Janke Kleynhans, Robert Reeve, Cathryn H. S. Driver, Biljana Marjanovic‐Painter, Mike Sathekge, Jan Rijn Zeevaart, Thomas Ebenhan, Robert P. Millar   +7 more
wiley   +1 more source

Radiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages

Scientific Reports, 2020
Folate receptor β (FR-β), a marker expressed on macrophages, is a promising target for imaging of inflammation. Here, we report the radiosynthesis and preclinical evaluation of [68Ga]Ga-NOTA-folate (68Ga-FOL).
Olli Moisio, S. Palani, J. Virta, Petri Elo, H. Liljenbäck, T. Tolvanen, Meeri Käkelä, Maxwell W. G. Miner, E. A. Herre, P. Marjamäki, T. Örd, M. Heinäniemi, M. Kaikkonen, Fenghua Zhang, M. Srinivasarao, J. Knuuti, P. Low, A. Saraste, Xiang-Guo Li, A. Roivainen   +19 more
semanticscholar   +1 more source