Results 111 to 120 of about 105,143 (344)

IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro

Cellular Physiology and Biochemistry, 2017
Background/Aims: Evidence suggests that IL-6 affects bone mass by modulating osteocyte communication towards osteoclasts. However, the mechanism by which IL-6 enhances osteocyte-mediated osteoclastogenesis is unclear.
Qing Wu, Xiaokang Zhou, Danqing Huang, Yingchen Ji, F. Kang   +4 more
semanticscholar   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Predictive analysis and prediction of the main molecular targets for the N-acetyl-6-aminohexanoate derivative

Research Results in Pharmacology
Introduction: N-acetyl-6-aminohexanoate (acexamic acid) and its derivatives are actively studied as promising compounds for the creation of new drugs, but their pharmacokinetic parameters and detailed mechanisms underlying a wide range of biochemical ...
Anton P. Danilenko, Alexey A. Khentov, Alexey V. Kuznetsov, Veronika S. Shmigerova, Yulia V. Stepenko, Alla P. Tarasova, Vladimir I. Yakushev, Elizaveta V. Boeva, Albina V. Miller, Irina A. Tatarenkova, Tatiana V. Puzanova, Yana V. Loboda, Andrei P. Trashchenko, Oleg S. Gudyrev, Anna L. Motailo, Vladimir N. Kuzichkin, Valentina N. Milashechko, Lyudmila M. Danilenko   +17 more
doaj   +1 more source

Prognostic Value and Quantitative CT Analysis in RANKL Expression of Spinal GCTB in the Denosumab Era: A Machine Learning Approach [PDF]

, 2022
Qizheng Wang, Yongye Chen, Siyuan Qin, Xiaoming Liu, Ke Liu, Peijin Xin, Weili Zhao, Huishu Yuan, Ning Lang   +8 more
openalex   +1 more source

Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells

Scientific Reports, 2017
Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produced by a variety
C. Streicher, A. Heyny, O. Andrukhova, Barbara Haigl, S. Slavic, C. Schüler, K. Kollmann, I. Kantner, V. Sexl, M. Kleiter, L. Hofbauer, P. Kostenuik, R. Erben   +12 more
semanticscholar   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Cellular and molecular mediators of bone metastatic lesions [PDF]

, 2018
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia, Del Fattore, Andrea, Marampon, Francesco, Rossi, Michela   +3 more
core   +2 more sources

NIR‐II Responsive Multifunctional Scaffold Enabling “Kill‐Modulation‐Build” Synergistic Therapy for Infectious Bone Defects

Advanced Science, EarlyView.
A novel multifunctional scaffold with photothermal effects is developed for infected bone defect repair. It facilitates angiogenesis and osteogenesis while eliminating bacteria through hyperthermia. Additionally, the scaffold promotes macrophage polarization from M1 to M2 via ROS scavenging, enhancing anti‐inflammatory activity. This study demonstrates
Qifei Yang, Shu Lou, Yuan Zhang, Zhurun Fang, Changyue Xing, Wentao Wang, Minxuan Han, Zhendong Wang, Ben Zhong Tang, Ming Zhang   +9 more
wiley   +1 more source

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

Cell, 2021
M. McDonald, Weng Hua Khoo, P. Ng, Ya Xiao, Jad Zamerli, Peter Thatcher, Wunna Kyaw, Karrnan Pathmanandavel, Abigail K. Grootveld, Imogen Moran, Danyal Butt, A. Nguyen, Alexander P Corr, S. Warren, M. Biro, N. Butterfield, Siobhan E. Guilfoyle, Davide Komla-Ebri, M. R. Dack, Hannah F. Dewhurst, J. Logan, Yongxiao Li, Sindhu T. Mohanty, Niall M Byrne, Rachael L. Terry, Marija K Simic, Ryan Chai, J. Quinn, Scott E. Youlten, J. Pettitt, D. Abi-Hanna, Rohit Jain, W. Weninger, Mischa Lundberg, Shuting Sun, F. H. Ebetino, P. Timpson, W. Lee, P. Baldock, M. Rogers, R. Brink, Graham R. Williams, J. Bassett, J. Kemp, N. Pavlos, P. Croucher, T. Phan   +46 more
semanticscholar   +1 more source

Steap4 Promotes Senile Osteoporosis via Fe2+‐ROS/C/EBPβ Feedback‐Driven Ferroptosis and Adipogenesis in Senescent BMSCs

Advanced Science, EarlyView.
Senescent bone marrow mesenchymal stem cells (BMSCs) exhibit increased sensitivity to ferroptosis, a phenomenon associated with Steap4, a nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)‐dependent metalloreductase that reduces Fe3+ to Fe2+.
Liangliang Wang, Guangrong Yin, Wenming Li, Maoyuan Li, Feng Lu, Chao Xu, Gongyin Zhao, Dechun Geng, Jiaxiang Bai, Yuji Wang   +9 more
wiley   +1 more source