Results 121 to 130 of about 59,926 (291)

RANKL overexpression induced epithelial to mesencymal transition.

, 2013
RANKL-transfected LNCaP cells induced EMT in histomorphology (A) and gene expression in mRNA (B) and protein (C). Data represent one of 3 RANKL-stably transfected and 2 neo-stably transfected LNCaP cell clones.
Hua Yang (120668), Fouad Habib (336949), Guodong Zhu (336946), Daniel Luthringer (336947), Haiyen E. Zhau (187248), Gail Prins (336948), Ruoxiang Wang (312686), Leland W. K. Chung (102625), Gina C.-Y. Chu (336945), Peizhen Hu (312688), Yuzhuo Wang (79735)   +10 more
core   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

The Circulating Levels of Osteoprotegerin and RANKL in Transfusion-dependent Beta-thalassemia Patients

Türk Osteoporoz Dergisi
Objective: β-thalassemia is a lifelong blood disorder with anemia and systemic effects. One of the complications commonly encountered in β-thalassemia, particularly with advancing age, includes weakened bones.
Karishma Saddiq, Anisa Hussain, Ahmad Jawad Mufti, Qaisar Azim, Naveed Sharif, Muhammad Ihtesham Khan, Gulab Fatima Rani   +6 more
doaj   +1 more source

IL-34 substitutes M-CSF in RANKL induced osteoclastogenesis.

, 2013
(A) IL-34, together with RANKL, induces osteoclastogenesis of bone marrow macrophages in a concentration-dependent manner, to comparable levels of M-CSF/RANKL.
Elisabeth A. Boström (495490), Pernilla Lundberg (61743)   +1 more
core   +1 more source

Modulation of Arachidonic Acid Metabolism by Pinoresinol Diglucoside Ameliorates Osteogenic Dysfunction via Coordinated NF‐κB Suppression and GSK3β/β‐Catenin Activation in Diabetic Osteoporosis

Phytotherapy Research, EarlyView.
ABSTRACT Diabetic osteoporosis (DOP) is characterized by chronic low‐grade inflammation and impaired bone formation. Pinoresinol diglucoside (PDG), a bioactive compound derived from Eucommia ulmoides Oliv., has shown therapeutic potential in metabolic bone disorders; however, its direct molecular targets and integrated mechanisms remain unclear.
Wenqi Jin, Yujing Tan, Lei Zhang, Weigeng She, Yunhang Chu, Xuenan Chen, Shuai Zhang, Liwei Sun   +7 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Effect of fungal microbiota on RANKL and sclerostin in patients with Crohn's disease

Journal of Advanced Biotechnology and Experimental Therapeutics
The etiology of Crohn's disease (CD) is still unknown. However, many factors, including a dysregulated immune system, altered microbiota, inheritance, and environmental factors, have been implicated. This work was conducted to estimate the effect of
Rana Hanan Al-rubaye, Hazima Mossa Alabassi, Anwar Khalil Ismael, Alaa Saad Hasan   +3 more
doaj   +1 more source

RANKL Increases Migration of Human Lung Cancer Cells Through Intercellular Adhesion Molecule-1 Up-Regulation

, 2012
[[abstract]]Invasion of distant tissues by tumor cells is the primary cause of therapeutic failure in the treatment of malignant lung cancer cells.
黃志揚;HUANG, CHIH-YANG
core  

Murine Rankl−/− Mesenchymal Stromal Cells Display an Osteogenic Differentiation Defect Improved by a RANKL-Expressing Lentiviral Vector

, 2017
Autosomal recessive osteopetrosis (ARO) is a severe bone disease characterized by increased bone density due to impairment in osteoclast resorptive function or differentiation.
Bortolomai I., Traggiai E., Villa A., Recordati C., Schena F., Tampieri A., Gattorno M., Sobacchi C., Sandri M., Palagano E., Caci E., Pastorino C., Martini A., Menale C., Bertoni A., Diomede L., Capo V., Gattorno M, Sobacchi C, Schena F, Bertoni A, Menale C, Traggiai E, Caci E, Capo V, Martini A, Sandri M, Recordati C, Villa A, Palagano E, Pastorino C, Diomede L, Tampieri A, Bortolomai I   +33 more
core   +1 more source

Disrupted joint clock is associated with rhythmic expression of bone destruction factors in collagen‐induced arthritis

Rheumatology &Autoimmunity, EarlyView.
Schematic Summary of Circadian Dysregulation in Arthritic Joints. This graphical abstract illustrates the key circadian disruptions observed in the collagen‑induced arthritis (CIA) model. The diagram depicts three main findings: (1) Nocturnal elevations in pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑17, IL‑1β, MIF) and bone‑destructive factors (DKK‑1 ...
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Jie Bai, Xing Feng, Yajing Wang, Zhenbin Li, Dongbao Zhao   +7 more
wiley   +1 more source