Results 131 to 140 of about 58,241 (294)

The Circulating Levels of Osteoprotegerin and RANKL in Transfusion-dependent Beta-thalassemia Patients

Türk Osteoporoz Dergisi
Objective: β-thalassemia is a lifelong blood disorder with anemia and systemic effects. One of the complications commonly encountered in β-thalassemia, particularly with advancing age, includes weakened bones.
Karishma Saddiq, Anisa Hussain, Ahmad Jawad Mufti, Qaisar Azim, Naveed Sharif, Muhammad Ihtesham Khan, Gulab Fatima Rani   +6 more
doaj   +1 more source

Regulación del metabolismo óseo a través del sistema RANK-RANKL-OPG

, 2011
La osteoporosis es una enfermedad caracterizada por una disminución de la resistencia ósea que predispone a un mayor riesgo de fracturas. El descubrimiento de la osteoprotegerina (OPG) y del ligando del receptor activador del factor nuclear kb (RANKL ...
Neyro Bilbao JL, Cano Sánchez A, Palacios Gil-Antuñano S   +2 more
core  

High‐Fat Diet Reprograms the Periapical Immune Landscape in a Mouse Model of Apical Periodontitis: A Spatial Transcriptomics Study

International Endodontic Journal, EarlyView.
ABSTRACT Introduction Apical periodontitis (AP) is an inflammatory disease of the periapical tissues driven by host responses to endodontic infection, and systemic metabolic disturbances, such as high‐fat diet (HFD)–induced dysmetabolism, may exacerbate tissue destruction. This study aimed to determine how chronic HFD exposure alters periapical myeloid
Maryam Ghaffari, Aiman Ali, Clement Hartadi, Annie Shrestha   +3 more
wiley   +1 more source

Effect of fungal microbiota on RANKL and sclerostin in patients with Crohn's disease

Journal of Advanced Biotechnology and Experimental Therapeutics
The etiology of Crohn's disease (CD) is still unknown. However, many factors, including a dysregulated immune system, altered microbiota, inheritance, and environmental factors, have been implicated. This work was conducted to estimate the effect of
Rana Hanan Al-rubaye, Hazima Mossa Alabassi, Anwar Khalil Ismael, Alaa Saad Hasan   +3 more
doaj   +1 more source

RANKL Increases Migration of Human Lung Cancer Cells Through Intercellular Adhesion Molecule-1 Up-Regulation

, 2012
[[abstract]]Invasion of distant tissues by tumor cells is the primary cause of therapeutic failure in the treatment of malignant lung cancer cells.
黃志揚;HUANG, CHIH-YANG
core  

Cardamonin inhibits RANKL-induced osteoclastogenesis.

, 2013
(A) RAW 264.7 cells (5×103/well) were incubated with cardamonin (500 nM) or RANKL (5 nM) alone, or with RANKL plus cardamonin (0, 50, 100, 250, 500 nM) for 5 days, and then stained for TRAP expression. TRAP-positive cells were photographed.
Sahdeo Prasad (340648), Simone Reuter (583976), Subash C. Gupta (583975), Vivek R. Yadav (583974), Akira Murakami (331566), Norio Yamamoto (112915), Bharat B. Aggarwal (332308), Bokyung Sung (340650)   +7 more
core   +1 more source

CD68 and F4/80 Markers Demonstrate Inflammatory Synergism Between Apical Periodontitis and Liver Fibrosis in Wistar Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate CD68 and F4/80 glycoproteins in the worsening of apical periodontitis (AP) and liver fibrosis (LF) in Wistar rats. Methodology Thirty‐two Wistar rats were distributed in the following groups (n = 8): C—control; AP—apical periodontitis; LF—liver fibrosis; APLF—AP and LF.
L. V. Barroti, C. Cantiga‐Silva, M. P. Justo, P. H. C. Oliveira, F. D. Faria, J. Goto, E. Ervolino, G. Sivieri‐Araújo, T. N. Pinheiro, L. T. A. Cintra   +9 more
wiley   +1 more source

Eccentric Occlusal Loads Remodel the Dentoalveolar and Temporomandibular Biomechanical Unit in Rats

Journal of Oral Rehabilitation, EarlyView.
Eccentric occlusal loads remodel the dentoalveolar and temporomandibular joints in the masticatory biomechanical unit in rats. (A) Bite block as an occlusal rise (OR) on the rat maxillary first molar (green region) is shown. (B) 18F‐NaF Positron emission tomography localised regions of higher metabolic activity (higher uptake in the left condyle ...
Haochen Ci, Umama Ali, Zhiyuan Yang, Ayush Bakandi, Nhu Huynh, Christine Nguyen, Brandon Lee, Youngho Seo, Robert Flavell, Alireza Hatamifar, Rishi J. Gupta, Rebeka Silva, Yongmei Wang, Bo Wang, Sunita P. Ho   +14 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source