Results 31 to 40 of about 394,130 (296)
RAS-MAPK in ALK targeted therapy resistance [PDF]
Cell Cycle, 2015 The clinical success of ALK targeted therapy is limited by resistance. To identify rational co-targeting strategies to enhance clinical outcomes, we explored the molecular basis of ALK oncogene dependence in ALK gene rearrangement positive (ALK+) lung adenocarcinoma.
Hrustanovic, Gorjan, Bivona, Trever G
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Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance In neurodegenerative disease, protein aggregates spread to neighboring cells to promote pathology. The in vivo regulation of toxic material transfer remains poorly understood, although mechanistic understanding should reveal previously ...
Jason F. Cooper +4 more
semanticscholar +1 more source
EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions
Journal of Cell Biology, 2021 Ras GTPases are key membrane-associated elements of the EGFR-MAPK signaling pathway. Surve et al. demonstrate that endogenous KRAS and NRAS are predominantly localized to the plasma membrane and its tubular shaped protrusions and show that a small pool ...
Sachin V. Surve +2 more
semanticscholar +1 more source
WormBook, 2006 Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) signaling pathways are used repeatedly during metazoan development to control many different biological processes. In the nematode Caenorhabditis elegans, two different RTKs (LET-23/EGFR and EGL-15/FGFR) are known to stimulate LET-60/Ras and a MAPK cascade consisting of the kinases LIN-45/Raf,
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Bone resorption in syndromes of the Ras/MAPK pathway [PDF]
Clinical Genetics, 2011 Disorders of the Ras/mitogen-activated protein kinase (MAPK) pathway have an overlapping skeletal phenotype (e.g. scoliosis, osteopenia). The Ras proteins regulate cell proliferation and differentiation and neurofibromatosis type 1 (NF1) individuals have osteoclast hyperactivity and increased bone resorption as measured by urine pyridinium crosslinks ...
D A, Stevenson +15 more
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Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo.
PLoS Genetics, 2020 Signal transduction pathways are intricately fine-tuned to accomplish diverse biological processes. An example is the conserved Ras/mitogen-activated-protein-kinase (MAPK) pathway, which exhibits context-dependent signaling output dynamics and regulation.
Jessica K Sawyer +9 more
doaj +1 more source
Life Science Alliance, 2019 Atmospheric oxygen levels modulate the RAS/MAPK signaling pathway in the nematode Caenorhabditis elegans through a cross-talk between the DELTA/NOTCH and hypoxia signaling pathways.
Sabrina Maxeiner +4 more
doaj +1 more source
The RAS/MAPK Axis Gets Stressed Out [PDF]
Molecular Cell, 2016 In this issue of Molecular Cell, Ritt et al. (2016) describe a stress-induced checkpoint that effectively suppresses RAS-MAPK signaling. This pathway, activated by agents such as Rigosertib that induce mitotic and oxidative stress, results in JNK-mediated inhibition of RAS-MAPK pathway components SOS and RAF.
Scott A, Foster, Shiva, Malek
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Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells. [PDF]
PLoS ONE, 2013 Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Vishwaroop Mulay +13 more
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PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development.
PLoS Genetics, 2012 Vulval development in Caenorhabditis elegans serves as an excellent model to examine the crosstalk between different conserved signaling pathways that are deregulated in human cancer.
Itay Nakdimon +3 more
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