Results 41 to 50 of about 394,130 (296)

CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

Nature Communications, 2022
In patients with melanoma, increased RAS/mitogen-activated protein kinase (MAPK) pathway activity is known to drive chemotherapy resistance. Here, the authors identify CDK12 as a downstream effector of the RAS/MAPK pathway and therapeutic target which ...
Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux   +12 more
doaj   +1 more source

The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways

Cell Reports, 2019
Summary: FBXW7 is a tumor suppressive E3 ligase, whereas RAS-ERK and mechanistic target of rapamycin kinase (mTORC1) are two major oncogenic pathways. Whether and how FBXW7 regulates these two oncogenic pathways are unknown. Here, we showed that SHOC2, a
Chuan-Ming Xie, Mingjia Tan, Xiao-Tong Lin, Di Wu, Yihan Jiang, Ye Tan, Haomin Li, Yuanyuan Ma, Xiufang Xiong, Yi Sun   +9 more
doaj   +1 more source

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy

Journal of Clinical Investigation, 2018
BACKGROUND. Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels that lead to stroke, life-threatening bleeds, disfigurement, overgrowth, and/or pain.
L. Al-Olabi, S. Polubothu, K. Dowsett, Katrina A Andrews, P. Stadnik, A. Joseph, R. Knox, A. Pittman, Graeme Clark, W. Baird, N. Bulstrode, M. Glover, K. Gordon, D. Hargrave, S. Huson, T. Jacques, G. James, Hannah C. Kondolf, L. Kangesu, K. Keppler-Noreuil, Amjad Khan, M. Lindhurst, M. Lipson, S. Mansour, J. O’Hara, C. Mahon, Anda Mosica, C. Moss, Aditi Murthy, J. Ong, V. Parker, J. Rivière, Julie C. Sapp, N. Sebire, R. Shah, B. Sivakumar, Anna Thomas, A. Virasami, R. Waelchli, Zhiqiang Zeng, L. Biesecker, A. Barnacle, M. Topf, R. Semple, E. E. Patton, V. Kinsler   +45 more
semanticscholar   +1 more source

Beep Test Does Not Induce Phosphorylation of Ras/MAPK- or JAK/STAT-Related Proteins in Peripheral Blood T Lymphocytes

Frontiers in Physiology, 2022
The Th1 cell subset is involved in the immunological response induced by physical exercise. The aim of this work is to evaluate the post-effort activation of Ras/MAPK and JAK/STAT signaling pathways in T cells of young, physically active men. Seventy-six
Dorota Kostrzewa-Nowak, Dorota Kostrzewa-Nowak, Robert Nowak   +2 more
doaj   +1 more source

RAS-MAPK Pathway Mutations in Congenital Pulmonary Airway Malformations. [PDF]

Am J Respir Crit Care Med
Windrich J, Braubach P, Länger F, Dingemann J, Schwerk N, Wetzke M, Renz DM, Zenker M, Schanze D, Kratz CP.   +9 more
europepmc   +3 more sources

Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins

Acta Pharmaceutica Sinica B, 2019
Members of the RAS proto-oncogene superfamily are indispensable molecular switches that play critical roles in cell proliferation, differentiation, and cell survival.
Yuan Zhang, Zhihua Wang, Xiaoyao Ma, Shengnan Yang, Xueyan Hu, Jin Tao, Yuanyuan Hou, Gang Bai   +7 more
doaj   +1 more source

NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS–MAPK Pathway in Neuroblastoma

Cancer Research, 2020
These findings suggest that conventional therapy–resistant, relapsed neuroblastoma may be effectively treated via combined inhibition of SHP2 and MEK or ERK of the RAS-MAPK pathway.
Ivette Valencia-Sama, Yagnesh Ladumor, Lynn Kee, T. Adderley, Gabriella Christopher, Claire M. Robinson, Y. Kano, M. Ohh, M. Irwin   +8 more
semanticscholar   +1 more source

Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling.

PLoS ONE, 2016
Pancreatic cancer has been found with abnormal expression or mutation in Ras proteins. Oncogenic Ras activation exploits their extensive signaling reach to affect multiple cellular processes, in which the mitogen-activated protein kinase (MAPK) signaling
Na Guo, Zuojia Liu, Wenjing Zhao, Erkang Wang, Jin Wang   +4 more
doaj   +1 more source

Abnormal activation of the Ras/MAPK signaling pathway in oncogenesis and progression

Cancer Advances
The Ras/MAPK signaling cascade plays an essential role in the regulation of cellular processes, including proliferation, differentiation, and survival, serving as a pivotal intracellular communication network.
Hong Xu, S. Ren, Yan Wang, Ting Zhang, Jun Lu   +4 more
semanticscholar   +1 more source

The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila. [PDF]

PLoS Biology, 2016
RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus. Disruption of this pathway is widely observed in cancer and other pathologies. Consequently, considerable effort has been devoted to understanding the mechanistic aspects
Dariel Ashton-Beaucage, Caroline Lemieux, Christian M Udell, Malha Sahmi, Samuel Rochette, Marc Therrien   +5 more
doaj   +1 more source