Results 21 to 30 of about 394,130 (296)

Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer

Theranostics, 2023
Background: Small cell lung cancer (SCLC) is an extremely aggressive cancer type with a patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an important role in triggering SCLC.
Karla Rubio, Addi J. Romero-Olmedo, Pouya Sarvari, Guruprasadh Swaminathan, V. Ranvir, Diana G. Rogel-Ayala, Julio Cordero, S. Günther, Aditi Mehta, B. Bassaly, P. Braubach, M. Wygrecka, S. Gattenlöhner, A. Tresch, Thomas Braun, G. Dobreva, Miguel N. Rivera, I. Singh, J. Graumann, G. Barreto   +19 more
semanticscholar   +1 more source

Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer

Cancer Discovery, 2022
The mechanisms underlying metabolic adaptation of pancreatic ductal adenocarcinoma (PDA) cells to pharmacological inhibition of RAS-MAPK signaling are largely unknown.
M. Ravichandran, Jingjie Hu, C. Cai, Nathan P. Ward, Anthony Venida, Callum Foakes, Miljan Kuljanin, A. Yang, Connor J Hennessey, Yang Yang, Brandon R. Desousa, G. Rademaker, A. Staes, Zeynep Cakir, I. Jain, A. Aguirre, J. Mancias, Yin Shen, G. DeNicola, R. Perera   +19 more
semanticscholar   +1 more source

Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers

Cancers, 2021
Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating cell proliferation, differentiation, and survival. Overexpression and overactivation of members within the signaling cascade have been observed in many solid and blood ...
M. Dillon, Antonio R Lopez, E. Lin, Dominic Sales, R. Perets, P. Jain   +5 more
semanticscholar   +1 more source

A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila. [PDF]

PLoS Biology, 2014
The small GTPase RAS is among the most prevalent oncogenes. The evolutionarily conserved RAF-MEK-MAPK module that lies downstream of RAS is one of the main conduits through which RAS transmits proliferative signals in normal and cancer cells. Genetic and
Dariel Ashton-Beaucage, Christian M Udell, Patrick Gendron, Malha Sahmi, Martin Lefrançois, Caroline Baril, Anne-Sophie Guenier, Jean Duchaine, Daniel Lamarre, Sébastien Lemieux, Marc Therrien   +10 more
doaj   +1 more source

MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model

Disease Models & Mechanisms, 2022
Costello syndrome (CS) is a congenital disorder caused by heterozygous activating germline HRAS mutations in the canonical Ras/mitogen-activated protein kinase (Ras/MAPK) pathway.
William E. Tidyman, Alice F. Goodwin, Yoshiko Maeda, Ophir D. Klein, Katherine A. Rauen   +4 more
doaj   +1 more source

RAS MAPK inhibitors deregulation in leukemia [PDF]

Oncoscience, 2015
The RAS (mitogen-activated protein kinase) MAPK pathway is commonly deregulated in human cancer, including childhood acute myeloid leukemias (AMLs). Canonical strong activating somatic mutation of RAS-MAPK pathway genes are recurrently found in AMLs. They affect integral components of the pathway, and upstream activators, and include NRAS, KRAS, BRAF ...
Eric, Pasmant, Dominique, Vidaud, Paola, Ballerini   +2 more
openaire   +2 more sources

Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA. [PDF]

PLoS Genetics, 2015
Human cancer is caused by the interplay of mutations in oncogenes and tumor suppressor genes and inherited variations in cancer susceptibility genes. While many of the tumor initiating mutations are well characterized, the effect of genetic background ...
Tobias Schmid, L Basten Snoek, Erika Fröhli, M Leontien van der Bent, Jan Kammenga, Alex Hajnal   +5 more
doaj   +1 more source

The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma

Clinical Cancer Research, 2022
Purpose: A consistent genetic alteration in vascular cancer epithelioid hemangioendothelioma (EHE) is the t(1;3)(p36;q25) chromosomal translocation, which generates a WWTR1(TAZ)-CAMTA1 (TC) fusion gene. TC is a transcriptional coactivator that drives EHE.
Shuang Ma, Ryan Kanai, A. Pobbati, Shuo Li, Kepeng Che, C. Seavey, Andrea Hallett, Ashley Burtscher, John M. Lamar, B. Rubin   +9 more
semanticscholar   +1 more source

A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma

Journal of experimental & clinical cancer research : CR, 2021
Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths.
V. Mlakar, Edouard Morel, S. Mlakar, M. Ansari, F. Gumy-Pause   +4 more
semanticscholar   +1 more source

Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition

Cancer Discovery, 2021
The RAS/MAPK pathway is an emerging targeted pathway across a spectrum of both adult and pediatric cancers. Typically, this is associated with a single, well-characterized point mutation in an oncogene.
B. Campbell, M. Galati, S. Stone, Alexandra N Riemenschneider, M. Edwards, S. Sudhaman, R. Siddaway, M. Komosa, N. Nunes, L. Nobre, A. Morrissy, M. Zatzman, M. Zápotocký, Lazar Joksimovic, S. Kalimuthu, David Samuel, G. Mason, E. Bouffet, D. Morgenstern, M. Aronson, C. Durno, D. Malkin, J. Maris, Michael D. Taylor, A. Shlien, Trevor J Pugh, P. Ohashi, C. Hawkins, U. Tabori   +28 more
semanticscholar   +1 more source