Results 1 to 10 of about 394,130 (296)

Photobiomodulation at 660 nm Stimulates In Vitro Diabetic Wound Healing via the Ras/MAPK Pathway [PDF]

Cells, 2023
Diabetic foot ulcers (DFUs) are open chronic wounds that affect diabetic patients due to hyperglycaemia. DFUs are known for their poor response to treatment and frequently require amputation, which may result in premature death.
Heidi Abrahamse, Nicolette Houreld, Houreld Nicolette N   +2 more
exaly   +5 more sources

Ras-MAPK pathway in patients with lupus nephritis [PDF]

Lupus Science and Medicine
Background Pathogenic mutations in genes encoding components of the Ras/mitogen-activated protein kinase (Ras-MAPK) pathway cause RASopathy. Here, we describe five unrelated patients with SLE carrying mutations associated with RASopathy and investigate ...
Dandan Liang, Zhihong Liu, Haitao Zhang, Changming Zhang, Jiahui Zhang, Ying Jin, Qing Zhong, JingXian Yu, Yangyang Zhang, Xiaoman Jing, Xingjian Gao   +10 more
doaj   +4 more sources

KRAS and RAS-MAPK Pathway Deregulation in Mature B Cell Lymphoproliferative Disorders

Cancers, 2022
Simple Summary KRAS and genes in the RAS-MAPK pathway are among the most frequently deregulated genes in solid tumors and in this context a large amount of KRAS and RAS-MAPK targeting molecules have been developed and tested.
Valter Gattei, Erika Tissino, Federico Pozzo   +2 more
exaly   +2 more sources

Accessory proteins of the RAS-MAPK pathway: moving from the side line to the front line

Communications Biology, 2021
Pudewell et al. discuss and advance our understanding of accessory proteins, which are crucial for the RTK-RAS-MAPK signalling cascade. They consider the therapeutic potential of targeting such modulators as an alternative to targeting constituent ...
Silke Pudewell, Christoph Wittich, Neda S. Kazemein Jasemi, Farhad Bazgir, Mohammad R. Ahmadian   +4 more
doaj   +2 more sources

Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

Signal Transduction and Targeted Therapy, 2022
Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2–selective inhibitor venetoclax (VEN) alone or in combinations commonly acquires resistance.
Qi Zhang, Bridget Riley-Gillis, Lina Han, Yanan Jia, Alessia Lodi, Haijiao Zhang, Saravanan Ganesan, Rongqing Pan, Sergej N. Konoplev, Shannon R. Sweeney, Jeremy A. Ryan, Yulia Jitkova, Kenneth Dunner, Shaun E. Grosskurth, Priyanka Vijay, Sujana Ghosh, Charles Lu, Wencai Ma, Stephen Kurtz, Vivian R. Ruvolo, Helen Ma, Connie C. Weng, Cassandra L. Ramage, Natalia Baran, Ce Shi, Tianyu Cai, Richard Eric Davis, Venkata L. Battula, Yingchang Mi, Jing Wang, Courtney D. DiNardo, Michael Andreeff, Jeffery W. Tyner, Aaron Schimmer, Anthony Letai, Rose Ann Padua, Carlos E. Bueso-Ramos, Stefano Tiziani, Joel Leverson, Relja Popovic, Marina Konopleva   +40 more
doaj   +2 more sources

Cemento-osseous dysplasia is caused by RAS-MAPK activation.

Pathology, 2022
Cemento-osseous dysplasia (COD) belongs to the spectrum of benign fibro-osseous lesions occurring exclusively in the tooth-bearing areas of the jaws. Depending on site and extent of involvement, periapical, focal and florid subtypes can be distinguished ...
S. Haefliger, Daniel Turek, Vanghelita Andrei, I. Alborelli, B. Calgua, Baptiste Ameline, D. Harder, D. Baumhoer   +7 more
semanticscholar   +3 more sources

RAS/MAPK inhibition in pediatric gliomas. [PDF]

Neurooncol Adv
Abstract Unresectable pediatric low-grade glioma is a chronic disease that can cause significant morbidity in young patients. Historically, treatment has mainly involved chemotherapy, with many patients needing multiple lines of treatment for a recurring/relapsing disease. Orally administered inhibitors targeting the rat sarcoma virus
Alshammari AJM, Hargrave D, Das A.
europepmc   +2 more sources

RAS/MAPK Pathway and RASopathies

Turkish Journal of Pediatric Disease
The RAS/Mitogen-Activated Protein Kinase (MAPK) pathway is a core developmental signaling cascade that regulates proliferation, differentiation, survival, and tissue growth across multiple organ systems.
A. Genç, Esra Kılıç
semanticscholar   +2 more sources

Ras/MAPK signaling from endomembranes [PDF]

Molecular Oncology, 2009
Signal transduction along the Ras/MAPK pathway has been generally thought to take place at the plasma membrane. It is now evident that the plasma membrane is not the only platform capable of Ras/MAPK signal induction. Fusion of Ras with green fluorescent protein and the development of genetically encoded fluorescent probes for Ras activation have ...
Nicole Fehrenbacher
exaly   +3 more sources

Phosphorylation of ASPP2 by RAS/MAPK Pathway Is Critical for Its Full Pro-Apoptotic Function [PDF]

PLoS ONE, 2013
We reported recently that apoptosis-stimulating protein of p53 (ASPP) 2, an activator of p53, co-operates with oncogenic RAS to enhance the transcription and apoptotic function of p53. However, the detailed mechanism remains unknown.
Yihua Wang
exaly   +2 more sources