Results 41 to 50 of about 1,467,466 (244)
International Journal of Nanomedicine, 2021 Hui Huang,1,2 Qinhui Liu,1 Ting Zhang,2 Jinhang Zhang,1,2 Jian Zhou,1,2 Xiandan Jing,2 Qin Tang,1 Cuiyuan Huang,1,2 Zijing Zhang,1 Yingnan Zhao,1,2 Guorong Zhang,1,2 Jiamin Yan,1,2 Yan Xia,1,2 Ying Xu,1,2 Jiahui Li,1,2 Yanping Li,1 Jinhan He1,2 ...
Huang H +16 more
doaj
RAS-mediated tumor stress adaptation and the targeting opportunities it presents
Disease Models & Mechanisms, 2022 Cellular stress is known to function in synergistic cooperation with oncogenic mutations during tumorigenesis to drive cancer progression. Oncogenic RAS is a strong inducer of a variety of pro-tumorigenic cellular stresses, and also enhances the ability ...
Alexandra Redding +2 more
doaj +1 more source
A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. [PDF]
, 2016 Synthetic protein switches controlled with user-defined inputs are powerful tools for studying and controlling dynamic cellular processes. To date, these approaches have relied primarily on intermolecular regulation.
Baker, David +12 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Peran Odontologi Forensik dalam Mengungkap Identitas Jenazah yang Tidak Dikenal
Jurnal Ilmu Kesehatan Indonesia, 2023 Latar belakang: Odontologi forensik merupakan salah satu metode untuk mengidentifikasi jenazah dalam bidang forensik. Metode tersebut terbukti lebih mudah, cepat, dan biaya yang dikeluarkan lebih sedikit.
Nur Anisa +2 more
doaj +1 more source
Silenced Expression of NFKBIA in Lung Adenocarcinoma Patients with a Never-smoking History [PDF]
, 2013 Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas.
Asano, Hiroaki +12 more
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Assignments of backbone 1H, 13C and 15N resonances in H-Ras (1–166) complexed with GppNHp at physiological pH [PDF]
, 2012 The small GTPase Ras is an important signaling molecule acting as a molecular switch in eukaryotic cells. Recent findings of global conformational exchange and a putative allosteric binding site in the G domain of Ras opened an avenue to understanding ...
Kovriguine, Evgueni, O\u27Connor, Casey
core +1 more source
An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients [PDF]
, 2008 Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters.
Bartlett, J.M.S. +5 more
core +3 more sources
Ras-GRF Activates Ha-Ras, but Not N-Ras or K-Ras 4B, Proteinin Vivo [PDF]
Journal of Biological Chemistry, 1998 Human cells contain four homologous Ras proteins, but it is unknown whether these homologues have different biological functions. As a first step in determining if Ras homologues might participate in distinct signaling cascades, we assessed whether a given Ras guanine nucleotide exchange factor could selectively activate a single Ras homologue in vivo.
M K, Jones, J H, Jackson
openaire +2 more sources