Results 1 to 10 of about 379,600 (302)
Monoterpene regulation of Ras and Ras-related protein expression [PDF]
Journal of Lipid Research, 2003 Monoterpenes, derived primarily from plants, are products of the isoprenoid biosynthetic pathway and function as chemical messengers with diverse functions. The biochemical bases for these activities are largely undefined.
Sarah A. Holstein, Raymond J. Hohl
doaj +5 more sources
The ubiquitin code of RAS proteins: Decoding its role in cancer progression [PDF]
iScienceSummary: RAS proteins, as the most frequently mutated oncoproteins in human cancers, drive tumor proliferation, metastasis, and therapeutic resistance.
Yedan Shi +6 more
doaj +2 more sources
The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis [PDF]
Cells, 2018 The exploitation of the yeast Saccharomyces cerevisiae as a biological model for the investigation of complex molecular processes conserved in multicellular organisms, such as humans, has allowed fundamental biological discoveries.
Giulia Cazzanelli +11 more
doaj +2 more sources
ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs [PDF]
Frontiers in Molecular BiosciencesADP-ribosylation factors (ARFs) are GTP-binding proteins that were discovered in the early 1980s, shortly after heterotrimeric GTP-binding proteins (G proteins) and nearly simultaneously with RAS.
Rachel E. Turn +5 more
doaj +2 more sources
Structure-based inhibitor design of mutant RAS proteins-a paradigm shift. [PDF]
Cancer Metastasis Rev, 2020 Nyíri K, Koppány G, Vértessy BG.
europepmc +3 more sources
Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy [PDF]
Pharmaceutical Sciences, 2022 Ras proteins are considered as one of the most critical cancer initiators. Mutations of this protein family lead to the continuous activation of the proliferation pathways.
Jeiran Pashapour-Anousheh +5 more
doaj +1 more source
Reorganization of Cell Compartmentalization Induced by Stress
Biomolecules, 2022 The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization.
Anna S. Fefilova +5 more
doaj +1 more source
RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains
Frontiers in Molecular Biosciences, 2021 RAS proteins are lipid-anchored small GTPases that switch between the GTP-bound active and GDP-bound inactive states. RAS isoforms, including HRAS, NRAS and splice variants KRAS4A and KRAS4B, are some of the most frequently mutated proteins in cancer. In
Yong Zhou +2 more
doaj +1 more source
Opposite functions of RapA and RapC in cell adhesion and migration in Dictyostelium
Animal Cells and Systems, 2021 There are three Rap proteins in Dictyostelium. RapA is a key regulator of cell adhesion and cytoskeletal rearrangement. Recently, RapC has been reported to be involved in cytokinesis, cell migration, and multicellular development.
Jihyeon Jeon +2 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2022 Ras family proteins are membrane-bound GTPases that control proliferation, survival, and motility. Many forms of cancers are driven by the acquisition of somatic mutations in a RAS gene.
Chitra Palanivel +6 more
doaj +1 more source