Results 31 to 40 of about 380,814 (333)
Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators
Acta Pharmaceutica Sinica B, 2021 RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of the ...
Yuran Qiu +10 more
doaj +1 more source
Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. [PDF]
, 2014 The renin-angiotensin system (RAS), bone morphogenetic protein (BMP), and WNT pathways are involved in pathogenesis of diabetic kidney disease (DKD).
Afkarian, Maryam +5 more
core +1 more source
Ras signaling through RASSF proteins [PDF]
Seminars in Cell & Developmental Biology, 2016 There are six core RASSF family proteins that contain conserved Ras Association domains and may serve as Ras effectors. They lack intrinsic enzymatic activity and appear to function as scaffolding and localization molecules. While initially being associated with pro-apoptotic signaling pathways such as Bax and Hippo, it is now clear that they can also ...
Howard, Donninger +4 more
openaire +2 more sources
Cell cycle-dependent activation of Ras [PDF]
, 1996 Background Ras proteins play an essential role in the transduction of signals from a wide range of cell-surface receptors to the nucleus. These signals may promote cellular proliferation or differentiation, depending on the cell background.
Stephen J Taylor +29 more
core +2 more sources
eLife, 2018 While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on cells ...
Alexander J Martinko +10 more
doaj +1 more source
Inhibition of Ral GTPases Using a Stapled Peptide Approach. [PDF]
, 2016 Aberrant Ras signaling drives numerous cancers, and drugs to inhibit this are urgently required. This compelling clinical need combined with recent innovations in drug discovery including the advent of biologic therapeutic agents, has propelled Ras back ...
Abell, Chris +7 more
core +2 more sources
Targeting Ras with protein engineering
Oncotarget, 2023 Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated with many types of cancer, making them attractive targets for cancer therapy. Despite extensive efforts, targeting Ras proteins with small molecules has been extremely challenging due to Ras's mostly flat surface and lack of small molecule ...
Tomazini, Atilio, Shifman, Julia M.
openaire +2 more sources
A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5.
PLoS Genetics, 2020 Dysregulation of the Ras oncogene in development causes developmental disorders, "Rasopathies," whereas mutational activation or amplification of Ras in differentiated tissues causes cancer.
Chalita Washington +7 more
doaj +1 more source
ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells [PDF]
, 2014 The RAS/ERK pathway is commonly activated in carcinomas and promotes oncogenesis by altering transcriptional programs. However, the array of cis-regulatory elements and trans-acting factors that mediate these transcriptional changes is still unclear. Our
Budka, Justin A. +3 more
core +1 more source
Ras Enhances Myc Protein Stability [PDF]
Molecular Cell, 1999 Various experiments have demonstrated a collaborative action of Myc and Ras, both in normal cell growth control as well as during oncogenesis. We now show that Ras enhances the accumulation of Myc activity by stabilizing the Myc protein. Whereas Myc has a very short half-life when produced in the absence of mitogenic signals, due to degradation by the ...
Sears, Rosalie +3 more
openaire +2 more sources