Results 31 to 40 of about 379,600 (302)
Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. [PDF]
, 2014 The renin-angiotensin system (RAS), bone morphogenetic protein (BMP), and WNT pathways are involved in pathogenesis of diabetic kidney disease (DKD).
Afkarian, Maryam +5 more
core +1 more source
Potent and selective eradication of tumor cells by an EpCAM-targeted Ras-degrading enzyme
Molecular Therapy: Oncolytics, 2023 Despite decades of efforts, an urgent need remains to develop tumor cell-selective rat sarcoma (Ras)-targeting therapies that can treat patients with Ras-driven tumors.
Valentina Palacio-Castañeda +5 more
doaj +1 more source
Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells [PDF]
, 1992 Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Frank, R. +5 more
core +1 more source
Ras signaling through RASSF proteins [PDF]
Seminars in Cell & Developmental Biology, 2016 There are six core RASSF family proteins that contain conserved Ras Association domains and may serve as Ras effectors. They lack intrinsic enzymatic activity and appear to function as scaffolding and localization molecules. While initially being associated with pro-apoptotic signaling pathways such as Bax and Hippo, it is now clear that they can also ...
Howard, Donninger +4 more
openaire +2 more sources
Cell cycle-dependent activation of Ras [PDF]
, 1996 Background Ras proteins play an essential role in the transduction of signals from a wide range of cell-surface receptors to the nucleus. These signals may promote cellular proliferation or differentiation, depending on the cell background.
Stephen J Taylor +29 more
core +2 more sources
eLife, 2018 While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on cells ...
Alexander J Martinko +10 more
doaj +1 more source
Inhibition of Ral GTPases Using a Stapled Peptide Approach. [PDF]
, 2016 Aberrant Ras signaling drives numerous cancers, and drugs to inhibit this are urgently required. This compelling clinical need combined with recent innovations in drug discovery including the advent of biologic therapeutic agents, has propelled Ras back ...
Abell, Chris +7 more
core +2 more sources
Targeting Ras with protein engineering
Oncotarget, 2023 Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated with many types of cancer, making them attractive targets for cancer therapy. Despite extensive efforts, targeting Ras proteins with small molecules has been extremely challenging due to Ras's mostly flat surface and lack of small molecule ...
Tomazini, Atilio, Shifman, Julia M.
openaire +2 more sources
A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5.
PLoS Genetics, 2020 Dysregulation of the Ras oncogene in development causes developmental disorders, "Rasopathies," whereas mutational activation or amplification of Ras in differentiated tissues causes cancer.
Chalita Washington +7 more
doaj +1 more source
Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters [PDF]
, 2013 Lipid-anchored Ras GTPases form transient, spatially segregated nanoclusters on the plasma membrane that are essential for high-fidelity signal transmission. The lipid composition of Ras nanoclusters however has not previously been investigated.
Abankwa +65 more
core +1 more source