Results 41 to 50 of about 380,814 (333)

κB-Ras Proteins Regulate Both NF-κB-Dependent Inflammation and Ral-Dependent Proliferation

Cell Reports, 2014
The transformation of cells generally involves multiple genetic lesions that undermine control of both cell death and proliferation. We now report that κB-Ras proteins act as regulators of NF-κB and Ral pathways, which control inflammation/cell death and
Andrea Oeckinghaus, Thomas S. Postler, Ping Rao, Heike Schmitt, Verena Schmitt, Yenkel Grinberg-Bleyer, Lars I. Kühn, Christian W. Gruber, Gustav E. Lienhard, Sankar Ghosh   +9 more
doaj   +1 more source

Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters [PDF]

, 2013
Lipid-anchored Ras GTPases form transient, spatially segregated nanoclusters on the plasma membrane that are essential for high-fidelity signal transmission. The lipid composition of Ras nanoclusters however has not previously been investigated.
Abankwa, Abankwa, Andresen, Ariotti, Baumgart, Brown, Brown, Casey, Cho, Deschout, Diggle, Dougherty, Epand, Garcia, Garg, Ghosh, Goldenberg, Gorfe, Gowrishankar, Grande-Garcia, Gutierrez, Hammond, Hancock, Hancock, Hancock, Hancock, Hill, Hong Liang, Jaumot, John F. Hancock, Kale, Kalwa, Kay, Kholodenko, Kiselev, Kiselev, Lee, Miao, Mor, Murakoshi, Nicholas Ariotti, Plowman, Plowman, Prior, Prior, Prior, Prior, Robert G. Parton, Rotblat, Roy, Schroeder, Sharma, Tian, Tian, Travis Rodkey, Treeck, van der Hoeven, van Rheenen, Veatch, Veatch, Voice, Yan, Yeung, Yong Zhou, Zeniou-Meyer, Zhou   +65 more
core   +1 more source

The Ins and Outs of RAS Effector Complexes

Biomolecules, 2021
RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status.
Christina Kiel, David Matallanas, Walter Kolch   +2 more
doaj   +1 more source

A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation [PDF]

, 1996
Oncogenic Ras transforms cells through the activation of multiple downstream pathways mediated by separate effector molecules, one of which is Raf. Here we report the identification of a second ras-binding protein that can induce cellular transformation ...
Camonis, J. H., Schaefer, E., Vale, T., White, M. A., Wigler, M. H.   +4 more
core   +1 more source

A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]

, 2020
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan, Campisi, Judith, Ferrucci, Luigi, Holtz, Anja, Jeon, Ok Hee, Kale, Abhijit, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Schilling, Birgit, Shah, Samah, Sharma, Vagisha   +11 more
core   +1 more source

PIK3CB and K-ras in oral squamous Cell carcinoma. A possible cross-talk!

Journal of Orofacial Sciences, 2014
Background: PIK3 and K-ras are signal transducing proteins involved and mediating many responses related to cell cycle growth regulation. Until date, there has been only limited evidence about the expression of K-ras and PKI3CB in oral squamous cell ...
Natheer H Al-Rawi, Muna S Merza, Aseel M Ghazi   +2 more
doaj   +1 more source

Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. [PDF]

, 2001
Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the ...
Chiang, SH, Kanzaki, M, Macara, IG, Mora, S, Pessin, JE, Saltiel, AR, Shigematsu, S, Watson, RT   +7 more
core   +3 more sources

Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

eLife, 2020
The RAS proteins are GTP-dependent switches that regulate signaling pathways and are frequently mutated in cancer. RAS proteins concentrate in the plasma membrane via lipid-tethers and hypervariable region side-chain interactions in distinct nano-domains.
Debanjan Goswami, De Chen, Yue Yang, Prabhakar R Gudla, John Columbus, Karen Worthy, Megan Rigby, Madeline Wheeler, Suman Mukhopadhyay, Katie Powell, William Burgan, Vanessa Wall, Dominic Esposito, Dhirendra K Simanshu, Felice C Lightstone, Dwight V Nissley, Frank McCormick, Thomas Turbyville   +17 more
doaj   +1 more source

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Nature Communications, 2021
Oncogenic RAS mutants remain difficult to target with small molecules. Here, the authors show that RAS-binding Affimer proteins inhibit RAS signaling while binding diverse regions on the RAS surface, suggesting the potential to use Affimers as tools to ...
Katarzyna Z. Haza, Heather L. Martin, Ajinkya Rao, Amy L. Turner, Sophie E. Saunders, Britta Petersen, Christian Tiede, Kevin Tipping, Anna A. Tang, Modupe Ajayi, Thomas Taylor, Maia Harvey, Keri M. Fishwick, Thomas L. Adams, Thembaninkosi G. Gaule, Chi H. Trinh, Matthew Johnson, Alexander L. Breeze, Thomas A. Edwards, Michael J. McPherson, Darren C. Tomlinson   +20 more
doaj   +1 more source

Analysis of Binding Site Hot Spots on the Surface of Ras GTPase [PDF]

, 2011
We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers.
Buhrman, Greg, Kearney, Bradley M., Kovrigina, Elizaveta A., Kovriguine, Evgueni, Kozakov, Dima, Mattos, Carla, Napoleon, Raeanne, O\u27Connor, Casey, Vajda, Sandor, Zerbe, Brandon   +9 more
core   +2 more sources