Results 41 to 50 of about 379,600 (302)
Ras Enhances Myc Protein Stability [PDF]
Molecular Cell, 1999 Various experiments have demonstrated a collaborative action of Myc and Ras, both in normal cell growth control as well as during oncogenesis. We now show that Ras enhances the accumulation of Myc activity by stabilizing the Myc protein. Whereas Myc has a very short half-life when produced in the absence of mitogenic signals, due to degradation by the ...
Sears, Rosalie +3 more
openaire +2 more sources
κB-Ras Proteins Regulate Both NF-κB-Dependent Inflammation and Ral-Dependent Proliferation
Cell Reports, 2014 The transformation of cells generally involves multiple genetic lesions that undermine control of both cell death and proliferation. We now report that κB-Ras proteins act as regulators of NF-κB and Ral pathways, which control inflammation/cell death and
Andrea Oeckinghaus +9 more
doaj +1 more source
ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells [PDF]
, 2014 The RAS/ERK pathway is commonly activated in carcinomas and promotes oncogenesis by altering transcriptional programs. However, the array of cis-regulatory elements and trans-acting factors that mediate these transcriptional changes is still unclear. Our
Budka, Justin A. +3 more
core +1 more source
The Ins and Outs of RAS Effector Complexes
Biomolecules, 2021 RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status.
Christina Kiel +2 more
doaj +1 more source
A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation [PDF]
, 1996 Oncogenic Ras transforms cells through the activation of multiple downstream pathways mediated by separate effector molecules, one of which is Raf. Here we report the identification of a second ras-binding protein that can induce cellular transformation ...
Camonis, J. H. +4 more
core +1 more source
PIK3CB and K-ras in oral squamous Cell carcinoma. A possible cross-talk!
Journal of Orofacial Sciences, 2014 Background: PIK3 and K-ras are signal transducing proteins involved and mediating many responses related to cell cycle growth regulation. Until date, there has been only limited evidence about the expression of K-ras and PKI3CB in oral squamous cell ...
Natheer H Al-Rawi +2 more
doaj +1 more source
eLife, 2020 The RAS proteins are GTP-dependent switches that regulate signaling pathways and are frequently mutated in cancer. RAS proteins concentrate in the plasma membrane via lipid-tethers and hypervariable region side-chain interactions in distinct nano-domains.
Debanjan Goswami +17 more
doaj +1 more source
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site
Nature Communications, 2021 Oncogenic RAS mutants remain difficult to target with small molecules. Here, the authors show that RAS-binding Affimer proteins inhibit RAS signaling while binding diverse regions on the RAS surface, suggesting the potential to use Affimers as tools to ...
Katarzyna Z. Haza +20 more
doaj +1 more source
H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis [PDF]
, 2002 dEndocytosis is required for efficient mitogen-activated protein kinase (MAPK) activation by activated growth factor receptors. We examined if H-Ras and K-Ras proteins, which are distributed across different plasma membrane microdomains, have equal ...
Hancock, J. F., Roy, S., Wyse, B.
core +2 more sources
Evaluating The Role Of Nitric Oxide Synthase In Oncogenic Ras-Driven Tumorigenesis
Redox Biology, 2015 We previously reported that oncogenic KRAS activation of the PI3K/AKT pathway stimulates the remaining wild-type HRAS and NRAS proteins in a manner dependent upon both eNOS expression and C118 in HRAS and NRAS, which promoted tumor growth.
Chris Counter
doaj +1 more source