Results 11 to 20 of about 226,892 (266)
Frontiers in Neuroscience, 2021 There is great interest in drug discovery programs targeted at the aggregation of the 42-residue form of the amyloid β peptide (Aβ42), since this molecular process is closely associated with Alzheimer’s disease.
Tatsuya Ikenoue +4 more
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Engineering of Reductive Aminases for Asymmetric Synthesis of Enantiopure Rasagiline
Frontiers in Bioengineering and Biotechnology, 2021 Reductive aminases (RedAms) for the stereoselective amination of ketones represent an environmentally benign and economically viable alternative to transition metal–catalyzed asymmetric chemical synthesis.
Kai Zhang +6 more
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BMC Genomics, 2017 Background Recombinant peptide chips could constitute a versatile complementation to state-of-the-art in situ (chemical on-chip) synthesis, particle-based printing, or pre-manufactured peptide spotting. Bottlenecks still impeding a routine implementation
Harald Hundsberger +5 more
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Rational Design of Nanozymes Enables Advanced Biochemical Sensing
Chemosensors, 2022 In comparison with bioenzymes, nanozymes exhibit excellent robustness against extreme conditions, a low production cost, and easy-to-adjust properties, as well as potential versatility.
Jinjin Liu, Xiangheng Niu
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Rational Design of AAV-rh74, AAV3B, and AAV8 with Limited Liver Targeting
Viruses, 2023 Recombinant adeno-associated viruses (rAAVs) have become one of the leading gene therapies for treating a variety of diseases. One factor contributing to rAAVs’ success is the fact that a wide variety of tissue types can be transduced by different ...
Christopher Chan +3 more
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Research Advances in Protein Engineering to Enhance the Thermal Stability of Glycosidase [PDF]
Shipin KexueGlycosidase is an indispensable enzyme in the sugar industry. It is difficult to maintain the stability of natural glycosidase during long-term high-temperature sugar conversion, limiting its application in industrial production.
WU Xiaoyi, WU Hao, YANG Can, WEN Shiyu, DUAN Yanting, TAN Wenzhi, XIE Yufei, CHENG Yunhui, WEN Li
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Viruses, 2021 Tick-borne encephalitis virus (TBEV) causes 5−7 thousand cases of human meningitis and encephalitis annually. The neutralizing and protective antibody ch14D5 is a potential therapeutic agent. This antibody exhibits a high affinity for binding with the D3
Ivan K. Baykov +4 more
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Molecules, 2023 Polyethylene terephthalate (PET) is one of the most prevalent transparent thermoplastics. It is commonly utilized due to its low cost and high durability.
Dongjian Huang, Lin Zhang, Yan Sun
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RATIONAL STEEL CORRUGATED PROFILE DESIGN
Nauka ta progres transportu, 2015 Purpose. The work sets forth the search results of new, more efficient design solutions for metal silos, namely, the analysis of existing types of profiles cross-section in a steel wall of such silo and development of less material-intensive section of ...
V. V. Kachurenko, D. O. Bannіkov
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Parallel Strategy Increases the Thermostability and Activity of Glutamate Decarboxylase
Molecules, 2020 Glutamate decarboxylase (GAD; EC 4.1.1.15) is a unique pyridoxal 5-phosphate (PLP)-dependent enzyme that specifically catalyzes the decarboxylation of L-glutamic acid to produce γ-aminobutyric acid (GABA), which exhibits several well-known ...
Qing-Fei Zhang +5 more
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