Results 11 to 20 of about 1,206,877 (302)

Engineering of Reductive Aminases for Asymmetric Synthesis of Enantiopure Rasagiline

Frontiers in Bioengineering and Biotechnology, 2021
Reductive aminases (RedAms) for the stereoselective amination of ketones represent an environmentally benign and economically viable alternative to transition metal–catalyzed asymmetric chemical synthesis.
Kai Zhang, Yuanzhi He, Jiawei Zhu, Qi Zhang, Luyao Tang, Li Cui, Yan Feng   +6 more
doaj   +1 more source

Assembly and use of high-density recombinant peptide chips for large-scale ligand screening is a practical alternative to synthetic peptide libraries

BMC Genomics, 2017
Background Recombinant peptide chips could constitute a versatile complementation to state-of-the-art in situ (chemical on-chip) synthesis, particle-based printing, or pre-manufactured peptide spotting. Bottlenecks still impeding a routine implementation
Harald Hundsberger, Kamil Önder, Peter Schuller-Götzburg, Dezso P. Virok, Julia Herzog, Raphaela Rid   +5 more
doaj   +1 more source

Rational Design of Nanozymes Enables Advanced Biochemical Sensing

Chemosensors, 2022
In comparison with bioenzymes, nanozymes exhibit excellent robustness against extreme conditions, a low production cost, and easy-to-adjust properties, as well as potential versatility.
Jinjin Liu, Xiangheng Niu
doaj   +1 more source

Variation in Boilerplate: Rational Design or Random Mutation? [PDF]

, 2014
Standard contract doctrine presumes that sophisticated parties choose their terminology carefully because they want courts or counterparts to understand what they intended.
Choi, Stephen J., Gulati, Mitu, Scott, Robert E.   +2 more
core   +3 more sources

Rational Design of AAV-rh74, AAV3B, and AAV8 with Limited Liver Targeting

Viruses, 2023
Recombinant adeno-associated viruses (rAAVs) have become one of the leading gene therapies for treating a variety of diseases. One factor contributing to rAAVs’ success is the fact that a wide variety of tissue types can be transduced by different ...
Christopher Chan, Kathryn K. Harris, Sergei Zolotukhin, Geoffrey D. Keeler   +3 more
doaj   +1 more source

Research Advances in Protein Engineering to Enhance the Thermal Stability of Glycosidase [PDF]

Shipin Kexue
Glycosidase is an indispensable enzyme in the sugar industry. It is difficult to maintain the stability of natural glycosidase during long-term high-temperature sugar conversion, limiting its application in industrial production.
WU Xiaoyi, WU Hao, YANG Can, WEN Shiyu, DUAN Yanting, TAN Wenzhi, XIE Yufei, CHENG Yunhui, WEN Li
doaj   +1 more source

Computational and Rational Design of Single-Chain Antibody against Tick-Borne Encephalitis Virus for Modifying Its Specificity

Viruses, 2021
Tick-borne encephalitis virus (TBEV) causes 5−7 thousand cases of human meningitis and encephalitis annually. The neutralizing and protective antibody ch14D5 is a potential therapeutic agent. This antibody exhibits a high affinity for binding with the D3
Ivan K. Baykov, Pavel Y. Desyukevich, Ekaterina E. Mikhaylova, Olga M. Kurchenko, Nina V. Tikunova   +4 more
doaj   +1 more source

Building Regular Registers with Rational Malicious Servers and Anonymous Clients [PDF]

, 2017
The paper addresses the problem of emulating a regular register in a synchronous distributed system where clients invoking $$\mathsf{read}()$$ and $$\mathsf{write}()$$ operations are anonymous while server processes maintaining the state of the register ...
Baldoni, Roberto, Bonomi, Silvia, DEL POZZO, Antonella, Lazzeretti, Riccardo   +3 more
core   +1 more source

Rational Design of Disulfide Bridges in BbPETase^CD for Enhancing the Enzymatic Performance in PET Degradation

Molecules, 2023
Polyethylene terephthalate (PET) is one of the most prevalent transparent thermoplastics. It is commonly utilized due to its low cost and high durability.
Dongjian Huang, Lin Zhang, Yan Sun
doaj   +1 more source

RATIONAL STEEL CORRUGATED PROFILE DESIGN

Nauka ta progres transportu, 2015
Purpose. The work sets forth the search results of new, more efficient design solutions for metal silos, namely, the analysis of existing types of profiles cross-section in a steel wall of such silo and development of less material-intensive section of ...
V. V. Kachurenko, D. O. Bannіkov
doaj   +1 more source