Results 21 to 30 of about 226,892 (266)
Frontiers in Microbiology, 2022 Halomonas bluephagenesis TD01 is one of the ideal chassis for low-cost industrial production based on “Next Generation Industrial Biotechnology,” yet the limited genetically regulatory parts such as transcriptional terminators, which are crucial for ...
Mengmeng Xu +7 more
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Antioxidants, 2023 Ferulic acid has numerous beneficial effects on human health, which are frequently attributed to its antioxidant behavior. In this report, many of them are reviewed, and 185 new ferulic acid derivatives are computationally designed using the CADMA-Chem ...
Eduardo Gabriel Guzmán-López +3 more
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Biology, 2021 l-asparaginase (EC 3.5.1.1) hydrolyzes l-asparagine to produce l-aspartate and ammonia and is widely found in microorganisms, plants, and some rodent sera. l-asparaginase used for industrial production should have good thermostability.
Xian Zhang +8 more
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The rational design of vaccines
Drug Discovery Today, 2005 This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. In addition, wider aspects are considered, such as biotechnological advances, advances in immunological understanding and host ...
Bramwell, Vincent W., Perrie, Yvonne
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Rationally designed tularemia vaccines [PDF]
Expert Review of Vaccines, 2009 Tularemia, caused by the Gram-negative bacterium Francisella tularensis, can be contracted by the bite of an arthropod vector or by inhalation. This disease occurs relatively infrequently but can be severe and even life-threatening if untreated. Until recently, there were few laboratories studying this organism; however, concerns over its potential use
Barbara J, Mann, Nicole M, Ark
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Frontiers in Pharmacology, 2023 Heterologous expression of L-asparaginase (L-ASNase) has become an important area of research due to its clinical and food industry applications. This review provides a comprehensive overview of the molecular and metabolic strategies that can be used to ...
Nicolás Lefin +7 more
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Strategies in the Rational Drug Design
Current Medicinal Chemistry, 2011 Rational design is applied in the discovery of novel lead drugs. Its rapid development is mainly attributed to the tremendous advancements in the computer science, statistics, molecular biology, biophysics, biochemistry, medicinal chemistry, pharmacokinetics and pharmacodynamics experienced in the last few decades.
T. Mavromoustakos +6 more
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Rational Design of Immunostimulatory siRNAs
Molecular Therapy, 2010 Short-interfering RNAs (siRNAs) have engendered much enthusiasm for their ability to silence the expression of specific genes. However, it is now well established that siRNAs, depending on their sequence, can be variably sensed by the innate immune system through recruitment of toll-like receptors 7 and 8 (TLR7/8).
Gantier, Michael P. +8 more
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Rational Drug Design Rational Drug Design
, 2017 For the past three decades rationale drug design (RDD) has been developing as an innovative, rapid and successful way to discover new drug candidates. Many strategies have been followed and several targets with diverse structures and different biological roles have been investigated. Despite the variety of computational tools available, one can broadly
Khaled H. Barakat +3 more
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Current Opinion in Structural BiologyProtein design enables the creation of novel structures and functions beyond those found in nature, with recent progress accelerated by computational modeling and machine learning. However, many automated methods act as black boxes, limiting mechanistic insight.
Joel J. Chubb +2 more
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