Results 41 to 50 of about 1,206,877 (302)
Scientific DataDecarbonisation of the industry sector is particularly challenging given its huge energy demand and high complexity of its various production processes. Additionally, regional differences in energy demand patterns affect the possible transition pathways.
Anđelka Kerekeš +9 more
doaj +1 more source
Structural Insights into the Design of Synthetic Nanobody Libraries
Molecules, 2022 Single domain antibodies from camelids, or nanobodies, are a unique class of antibody fragments with several advantageous characteristics: small monomeric size, high stability and solubility and easy tailoring for multiple applications.
Mario S. Valdés-Tresanco +3 more
doaj +1 more source
ShearLab: A Rational Design of a Digital Parabolic Scaling Algorithm [PDF]
, 2011 Multivariate problems are typically governed by anisotropic features such as edges in images. A common bracket of most of the various directional representation systems which have been proposed to deliver sparse approximations of such features is the ...
Gitta Kutyniok +4 more
core +1 more source
Rational material design of mixed-valent high T$_c$ superconductors
, 2013 We design, from first principles calculations, a novel family of thallium halide-based compounds as candidates for new high temperature superconductors, whose superconductivity is mediated by the recently proposed mechanism of non-local correlation ...
Kotliar, G., Yin, Z. P.
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Developments in the tools and methodologies of synthetic biology. [PDF]
, 2014 Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to ...
Freemont, P +3 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Inverse Quantum Chemistry: Concepts and Strategies for Rational Compound Design [PDF]
, 2014 The rational design of molecules and materials is becoming more and more important. With the advent of powerful computer systems and sophisticated algorithms, quantum chemistry plays an important role in rational design.
Reiher, Markus, Weymuth, Thomas
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Motivation to become an entrepreneur: a study of Nigerian women's decisions [PDF]
, 2011 Purpose – The paper aims to draw on rational choice theory (RCT) to explore factors underpinning the decision by female entrepreneurs in Nigeria to enter self-employment.
Mordi , Chima +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source