Results 51 to 60 of about 1,206,877 (302)

Rational design of a flavoenzyme for aerobic nicotine catabolism

mBio
Enzymatic therapy with nicotine-degrading enzyme is a new strategy in treating nicotine addiction, which can reduce nicotine concentrations and weaken withdrawal in the rat model.
Haiyang Hu, Zhaoyong Xu, Zhiyao Zhang, Peizhi Song, Frederick Stull, Ping Xu, Hongzhi Tang   +6 more
doaj   +1 more source

Concerns in the Design and Development of Novel Antimicrobial Peptides

Trends in Peptide and Protein Sciences, 2017
Peptide and protein based therapeutics are the most promising approaches in today medicine. Bioactive peptides can be valuable drugs in the treatment of various illnesses, such as cardiovascular and neurodegenerative diseases.
Parvaneh Panahi Chegini, Iraj Nikokar, Tahereh Hosseinabadi, Maryam Tabarzad   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Rational Design of a Truncated β-Galactosidase from Bacillus sp. and Its Application in the Synthesis of Lacto-N-neotetraose

Shipin gongye ke-ji
Objective: A truncated β-galactosidase (BsGal95-D) from Bacillus sp. S3 was biochemically characterized, engineered through rational design, and applied in lacto-N-neotetraose (LNnT) synthesis. Methods: The truncated β-galactosidase gene (BsGal95-D) from
Jianyu WANG, Zhixuan XIANG, Dan LIU, Zhengqiang JIANG, Qiaojuan YAN   +4 more
doaj   +1 more source

Rethinking network reciprocity over social ties: local interactions make direct reciprocity possible and pave the rational way to cooperation

, 2018
Since Nowak & May's (1992) influential paper, network reciprocity--the fact that individuals' interactions repeated within a local neighborhood support the evolution of cooperation--has been confirmed in several theoretical models.
axelrod, gabor lippner, gracia-lazaro, gruji?, nowak, szabó   +5 more
core   +2 more sources

Protective wrapping of off-the-shelf components [PDF]

, 2005
System designers using off-the-shelf components (OTSCs), whose internals they cannot change, often use add-on “wrappers” to adapt the OTSCs’ behaviour as required.
Jefferson, N., Riddle, S., Strigini, L., van der Meulen, M.   +3 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Special Issue: “Molecules against Alzheimer”

Molecules, 2016
This Special Issue, entitled “Molecules against Alzheimer”, gathers a number of original articles, short communications, and review articles on recent research efforts toward the development of novel drug candidates, diagnostic agents and therapeutic ...
Michael Decker, Diego Muñoz-Torrero
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Principle of Virtual Work as Foundational Framework for Metamaterial Discovery and Rational Design

Comptes Rendus. Mécanique, 2023
Novel theories are needed for the discovery of innovative and exotic metamaterial and for their rational design. The current practice of mechanical analyses based upon moribund classical theories and experimental trial-error campaigns is caught in an ...
dell’Isola, Francesco, Misra, Anil
doaj   +1 more source