Results 71 to 80 of about 1,206,877 (302)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Enhancement of the Thermostability of Microbacterium Esterase by Combinatorial Rational Design
MoleculesThe esterase EstSIT01 from Microbacterium can catalyze the asymmetric hydrolysis of meso-dimethyl ester to produce the crucial chiral intermediate (4S, 5R)-hemimethyl ester for d-biotin synthesis.
Wenyu Peng, Xiaomei Wu, Baodi Ma, Yi Xu
doaj +1 more source
Rational Design and Biotechnological Production of Novel AfpB-PAF26 Chimeric Antifungal Proteins
Microorganisms, 2018 Antimicrobial peptides (AMPs) have been proposed as candidates to develop new antimicrobial compounds for medicine, agriculture, and food preservation.
Marcos Heredero +4 more
doaj +1 more source
Making 3D-Cry Toxin Mutants: Much More Than a Tool of Understanding Toxins Mechanism of Action
Toxins, 2020 3D-Cry toxins, produced by the entomopathogenic bacterium Bacillus thuringiensis, have been extensively mutated in order to elucidate their elegant and complex mechanism of action necessary to kill susceptible insects.
Susana Vílchez
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Dependence of the thickness of laminated load-bearing composite panels on the fiber angles [PDF]
Космические аппараты и технологииThe designing of thin-walled panels made of laminated composites of minimal weight constrained by strength and buckling is difficult and time-consuming because buckling strongly depends on bending stiffness.
Yu. I. Badrukhin, E. S. Terekhova
doaj
Parametric macromodeling of lossy and dispersive multiconductor transmission lines [PDF]
, 2010 We propose an innovative parametric macromodeling technique for lossy and dispersive multiconductor transmission lines (MTLs) that can be used for interconnect modeling.
Antonini, G. +3 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Performance pay, group selection and group performance [PDF]
, 2007 Within a laboratory experiment we investigate a principal-agent game in which agents may, first, self-select into a group task (GT) or an individual task (IT) and, second, choose work effort.
Konigstein, M., Luenser, G.
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source