Results 61 to 70 of about 1,206,877 (302)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Optimal designs for rational function regression
, 2011 We consider optimal non-sequential designs for a large class of (linear and nonlinear) regression models involving polynomials and rational functions with heteroscedastic noise also given by a polynomial or rational weight function.
A. Dembo +92 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The "Divine Design" argument in the English philosophy of nature in the 17th century [PDF]
Вестник Православного Свято-Тихоновского гуманитарного университета: Серия I. Богословие, философия, 2014 The article deals with the development of the teleological argument (the design argument) as elaborated in the works of the English natural philosophers Robert Boyle and John Ray.
Igor Koshelev
doaj +1 more source
Creating a New Vision of the Urban High School [PDF]
, 2000 Provides an assessment of current school structure and explores the rational for changing the design of public education. Looks at recent efforts to organize and fund urban schools, in search of a solution to the problem of high school ...
Joyce Baldwin
core
A Parameterization Scheme for Lossy Transmission Line Macromodels with Application to High Speed Interconnects in Mobile Devices [PDF]
, 2007 We introduce a novel parameterization scheme based on the generalized method of characteristics (MoC) formacromodels of transmission-line structures having a cross section depending on several free geometrical and material parameters.
Acquadro, S. +5 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Crafting political institutions in Africa : electoral systems and systems of government in Rwanda and Zambia compared [PDF]
, 2007 Scholars of institutional design attribute large importance to the choice of new institutions. The comparative analysis of how Rwanda and Zambia crafted their new electoral systems and the systems of government regards procedural, structural and rational
Stroh, Alexander
core +1 more source