Results 11 to 20 of about 17,435 (223)

Quantifying Systematic RBE-Weighted Dose Uncertainty Arising from Multiple Variable RBE Models in Organ at Risk

Advances in Radiation Oncology, 2022
Purpose: Relative biological effectiveness (RBE) uncertainties have been a concern for treatment planning in proton therapy, particularly for treatment sites that are near organs at risk (OARs).
Wei Yang Calvin Koh, BSc, Hong Qi Tan, PhD, Yan Yee Ng, MSc, Yen Hwa Lin, PhD, Khong Wei Ang, MSc, Wen Siang Lew, PhD, James Cheow Lei Lee, PhD, Sung Yong Park, PhD   +7 more
doaj   +2 more sources

Brainstem NTCP and Dose Constraints for Carbon Ion RT—Application and Translation From Japanese to European RBE-Weighted Dose [PDF]

Frontiers in Oncology, 2020
Background and PurposeThe Italian National Center of Oncological Hadrontherapy (CNAO) has applied dose constraints for carbon ion RT (CIRT) as defined by Japan’s National Institute of Radiological Sciences (NIRS).
Jon Espen Dale, Jon Espen Dale, Silvia Molinelli, Barbara Vischioni, Viviana Vitolo, Maria Bonora, Giuseppe Magro, Andrea Mairani, Andrea Mairani, Azusa Hasegawa, Azusa Hasegawa, Tatsuya Ohno, Olav Dahl, Francesca Valvo, Piero Fossati, Piero Fossati   +15 more
doaj   +2 more sources

Dynamic Proton arc therapy for paediatric parameningeal rhabdomyosarcoma. [PDF]

J Appl Clin Med Phys
Abstract Background Parameningeal rhabdomyosarcomas (PM‐RMS) are pediatric tumors with a high risk of local failure and severe toxicity. Intensity modulated proton therapy (IMPT) offers improved healthy tissue sparing compared to conventional photon‐based radiotherapy, and proton arc therapy (PAT) might offer further improvement in healthy tissue ...
Handeland AH, Grewal HS, Boer CG, Indelicato DJ, Ytre-Hauge KS, Henjum H, Stokkevåg CH.   +6 more
europepmc   +2 more sources

Proton arc therapy reduces the dose delivered to circulating blood compared to intensity-modulated proton therapy for head-and-neck cancer. [PDF]

J Appl Clin Med Phys
Background Compared to intensity‐modulated proton therapy (IMPT), proton arc therapy (PAT) has various dosimetric advantages. However, questions have been raised over whether the larger low‐dose bath during PAT may increase radiation‐induced lymphocyte killing, which is correlated with adverse clinical outcomes.
Tattenberg S, Liu P, Cong X, Hoehr C, Ding X.   +4 more
europepmc   +2 more sources

Study of Biological Effects of Fast Neutrons (2-14 MeV) Using Monte Carlo Method on DNA Atomic Model [PDF]

مجله علوم و فنون هسته‌ای, 2020
This study investigates the direct effect of fast neutrons with the energy ranging from 2MeV to 14MeV, and calculates the single-strand break and double-strand break on the Deoxyribon Nucleic Acid (DNA) atomic structure, using Monte Carlo method. To this
A. Zabihi, Gh. Forozani, F. Semsarha, A. Moslehi, P. Rezaeian   +4 more
doaj   +1 more source

Impact of anatomical changes on simulated proton arc therapy and intensity-modulated proton therapy for lung cancer. [PDF]

J Appl Clin Med Phys
Abstract Purpose : During lung cancer radiotherapy, inter‐fractional anatomical changes may cause the delivered dose to deviate from the primary plan, affecting tumor control and increasing the risk of normal tissue damage. This study aims to evaluate the impact of anatomical changes on the dosimetric and radiobiological performance of simulated proton
Chen W, Yang F, Zeng F, Guo H, Xu Y, Zhang T, Wu J, Zhang D, Liu G, Ding X, Wang X.   +10 more
europepmc   +2 more sources

Gonadal transcriptomes associated with sex phenotypes provide potential male and female candidate genes of sex determination or early differentiation in Crassostrea gigas, a sequential hermaphrodite mollusc

BMC Genomics, 2021
Background In the animal kingdom, mollusca is an important phylum of the Lophotrochozoa. However, few studies have investigated the molecular cascade of sex determination/early gonadal differentiation within this phylum. The oyster Crassostrea gigas is a
Coralie Broquard, Suwansa-ard Saowaros, Mélanie Lepoittevin, Lionel Degremont, Jean-Baptiste Lamy, Benjamin Morga, Abigail Elizur, Anne-Sophie Martinez   +7 more
doaj   +1 more source

Vision and implementation for the first U.S. carbon ion therapy center part I: Clinical rationale and the need for CIRT in the United States. [PDF]

J Appl Clin Med Phys
Abstract Carbon ion radiotherapy (CIRT) has evolved into an established clinical modality over the past three decades. Owing to its unique physical and biological characteristics, CIRT has demonstrated favorable outcomes for selected malignancies characterized by radioresistance, proximity to critical organs, locally advanced disease requiring safe ...
Liang X, Beltran CJ.
europepmc   +2 more sources

Reactive oxygen species and senescence modulatory effects of rice bran extract on 4T1 and NIH-3T3 cells co-treatment with doxorubicin

Asian Pacific Journal of Tropical Biomedicine, 2021
Objective: To determine the effect of rice bran extract (RBE) in combination with doxorubicin on 4T1 triple-negative breast cancer cells and NIH-3T3 cells. Methods: RBE was obtained by maceration with n-hexane.
Ummi Maryam Zulfin, Ave Rahman, Mila Hanifa, Rohmad Yudi Utomo, Sari Haryanti, Edy Meiyanto   +5 more
doaj   +1 more source

Impact of robust optimization and beam configuration on the distribution stability of LET under delivery uncertainties in carbon-ion therapy. [PDF]

J Appl Clin Med Phys
Abstract Background Carbon‐ion radiotherapy exploits high linear energy transfer (LET) to enhance biological effectiveness, and low dose‐averaged LET (LETd) within the target volume is associated with local recurrence in pancreatic cancer. Although robust optimization is widely used to improve dose robustness against delivery uncertainties, systematic ...
Phongprapun W, Tashiro M.
europepmc   +2 more sources