The Organ Sparing Potential of Different Biological Optimization Strategies in Proton Therapy
Advances in Radiation Oncology, 2021 Purpose: Variable relative biological effectiveness (RBE) models allow for differences in linear energy transfer (LET), physical dose, and tissue type to be accounted for when quantifying and optimizing the biological damage of protons.
Helge Henjum, MSc +7 more
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RBE and the Primary Mechanism of Radiation Action [PDF]
Radiation Research, 1971 The dependence of RBE on dose appears to follow a simple relation for a variety of effects on higher organisms and for a broad range of doses. The data indicate that the biological effects are due to primary lesions that may be produced by one or two high LET particles but require the action of at least two electrons when electromagnetic radiation is ...
Kellerer, Albrecht M., Rossi, H. H.
openaire +3 more sources
Widespread complex enameloid microstructure in teeth and rostral denticles of Cretaceous sclerorhynchoid skates (Rajiformes: †Sclerorhynchoidei). [PDF]
J AnatThis article demonstrates that the teeth and rostral denticles of an extinct clade of sawfish‐like skates display an extremely derived enameloid microstructure, similar to what is known among sharks. The presence of tooth‐like enameloid microstructure in dermal denticles opens new perspectives about the origins and development of chondrichthyan ...
Chateauneuf-Gautier E, Guinot G.
europepmc +2 more sources
Parasites & Vectors, 2018 Background Microcell parasites are small intracellular protozoans mostly detected in molluscs and can be associated with mortalities. In 2010 and 2011, strong increases in mortality events were reported in different wild beds of the wedge clam Donax ...
Céline Garcia +13 more
doaj +1 more source
Dynamic control of carbon-ion radiation dose distribution amid respiratory motion challenges: A review of prediction research using geant4 and deep learning physics-constrained models. [PDF]
J Appl Clin Med PhysAbstract Background Carbon ion radiotherapy (CIRT) offers superior dose conformity and biological effectiveness; however, its precision is highly sensitive to respiratory motion, leading to dose uncertainty and interplay effects that compromise treatment accuracy.
Ding J, Li P, Yeong CH.
europepmc +2 more sources
Proton RBE models: commonalities and differences [PDF]
Physics in Medicine & Biology, 2021 Abstract Uncertainties in the relative biological effectiveness (RBE) of protons remains a major barrier to the biological optimisation of proton therapy. While a constant value of 1.1 is widely used in treatment planning, extensive preclinical in vitro and
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Integrating microdosimetric in vitro RBE models for particle therapy into TOPAS MC using the MicrOdosimetry-based modeling for RBE Assessment (MONAS) tool [PDF]
, 2023 We present MONAS (MicrOdosimetry-based modelliNg for relative biological effectiveness (RBE) ASsessment) toolkit. MONAS is a TOPAS Monte Carlo extension, that combines simulations of microdosimetric distributions with radiobiological microdosimetry-based
Cartechini, Giorgio +4 more
core +1 more source
Radiation Oncology, 2022 Background The study objective was to validate the relative biological effectiveness (RBE) in RayStation for carbon-ion radiotherapy (CIRT) using the Syngo treatment planning system as reference. Methods Local effect model I was established in RayStation
Weiwei Wang +5 more
doaj +1 more source
Advanced treatment planning: robust optimization and proton RBE [PDF]
, 2022 This thesis aims to improve the way uncertainties are incorporated in the treatment planning process of radiotherapy treatments.By using robust optimization instead of the more commonly used PTV-optimization the effects of movement on the radiation dose ...
Wagenaar, Dirk; id_orcid +2 more
core +1 more source
Proton relative biological effectiveness (RBE): a multiscale problem [PDF]
, 2018 Proton radiotherapy is undergoing rapid expansion both within the UK and internationally, but significant challenges still need to be overcome if maximum benefit is to be realised from this technique. One major limitation is the persistent uncertainty in
Underwood, Tracy +1 more
core +1 more source