Results 1 to 10 of about 130,598 (99)

Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11

Pharmaceutical Biology, 2023
Context Ferroptosis may play an essential role in lipid peroxidation and endothelial dysfunction of aortic endothelial cells (ECs) in type 2 diabetes mellitus (T2DM) with atherosclerosis (AS).
Jianjie Rong, Chuanyong Li, Qiang Zhang, Guangfeng Zheng, Weijian Fan, Zhichang Pan, Shuming Shi   +6 more
semanticscholar   +1 more source

Evaluation of the Expression Levels of miR-21-5p and miR-429 Genes in Biopsy Samples from Patients with Oral Squamous Cell Carcinoma

Diagnostics, 2023
Introduction: MicroRNAs (miRs) are a group of endogenous, non-coding, 18-24 nucleotide length single-strand RNAs that mediate gene expression at the post-transcriptional level through mRNA degradation or translational repression.
A. Garajei, A. Allameh, Mehdi Azadi, A. Emami, M. Atashbasteh, Melina Mostafavi, Bayazid Ghaderi, F. Inchingolo, M. Sadeghi, SK Tadakamadla, Hady Mohammadi, J. Tadakamadla   +11 more
semanticscholar   +1 more source

The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1

Aging, 2023
Lines of evidence have demonstrated that the oncogenic miRNAs are pivotal to the progression of breast cancer. In this study, we investigated the biological traits of microRNA-429 (miR-429) in triple-negative breast cancer (TNBC) and the underlying ...
Yao Li, Xue Meng, Yuqing Luo, S. Luo, Jin Li, Jiafei Zeng, Xiang Huang, Jinjing Wang   +7 more
semanticscholar   +1 more source

Upregulated microRNA-429 confers endometrial stromal cell dysfunction by targeting HIF1AN and regulating the HIF1A/VEGF pathway

Open Medicine, 2023
Endometriosis (EM) is a prevalent estrogen-dependent disorder that adversely affects the life quality of many reproductive-age women. Previous evidence has suggested the significant role of miR-429 in EM; however, its molecular mechanisms underlying EM ...
R. Zheng, Yulan Liu, Yan Lei, Yan Yue
semanticscholar   +1 more source

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429

Frontiers in Genetics, 2022
Platinum-based cytotoxic chemotherapy is considered the standard treatment for advanced gastric cancer (GC). However, cisplatin chemoresistance often occurs with the mechanisms being not well clarified, which results in the cancer recurrence and poor ...
Xiaofeng Wang, Rui He, L. Geng, Jing Yuan, H. Fan   +4 more
semanticscholar   +1 more source

Angiogenesis Driven by the CEBPD–hsa-miR-429–VEGFA Signaling Axis Promotes Urothelial Carcinoma Progression

Cells, 2022
Background and Purpose: This research aimed to excavate the alternative mechanism of CEBPD on tumor growth and explore the biological significance of the CEBPD/hsa-miR-429/VEGFA axis on angiogenesis in urothelial carcinoma (UC).
T. Chan, C. Hsing, Y. Shiue, Steven K. Huang, Kun-Lin Hsieh, Yu-Hsuan Kuo, Chien-Feng Li   +6 more
semanticscholar   +1 more source

MAPKAPK5-AS1 drives the progression of hepatocellular carcinoma via regulating miR-429/ZEB1 axis

BMC Molecular and Cell Biology, 2022
Background Hepatocellular carcinoma (HCC) is a common malignancy. Long non-coding RNAs (lncRNAs) partake in the progression of HCC. However, the role of lncRNA MAPKAPK5-AS1 in the development of HCC has not been fully clarified.
Z. Peng, Xin-ping Ouyang, Yexing Wang, Qiming Fan   +3 more
semanticscholar   +1 more source

miR‐200a/b/‐429 downregulation is a candidate biomarker of tumor radioresistance and independent of hypoxia in locally advanced cervical cancer

Molecular Oncology, 2022
Many patients with locally advanced cervical cancer experience recurrence within the radiation field after chemoradiotherapy. Biomarkers of tumor radioresistance are required to identify patients in need of intensified treatment.
A. Nilsen, T. Hillestad, V. Skingen, E. Aarnes, C. Fjeldbo, T. Hompland, T. S. Evensen, T. Stokke, G. Kristensen, B. Grallert, H. Lyng   +10 more
semanticscholar   +1 more source

The decreased expression of miR-429 in plasma exosomes after spinal cord injury inhibits neuronal apoptosis by mediating the PTEN/PI3K/Akt pathway

Annals of Translational Medicine, 2022
Background Neuronal apoptosis after spinal cord injury (SCI) leads to sensorial and motorial dysfunction. Exosomes are vesicles that contain many cellular components, including microRNA, and the role of miR-429 in plasma exosomes in this process after ...
Jiayi Huang, Chunshuai Wu, Guanhua Xu, Yue Sun, Chao Gui, Jiawei Fu, Zhiming Cui, Haiming Huang   +7 more
semanticscholar   +1 more source

FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation

Cell Death and Disease, 2021
It is widely accepted that lysosomes are essential for cell homeostasis, and autophagy plays an important role in tumor development. Here, we found FV-429, a synthetic flavonoid compound, inhibited autophagy flux, promoted autophagosomes accumulation ...
Po Hu, Jubo Wang, Yingjie Qing, Hui Li, Wenzhuo Sun, Xiaoxuan Yu, H. Hui, Q. Guo, Jingyan Xu   +8 more
semanticscholar   +1 more source