Results 111 to 120 of about 2,150 (202)

Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase

Viruses, 2015
The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp).
Xinran Liu, Derek M. Musser, Cheri A. Lee, Xiaorong Yang, Jamie J. Arnold, Craig E. Cameron, David D. Boehr   +6 more
doaj   +1 more source

The Influence of Irradiation Wavelength on the Growth of Polymer Brushes by SI‐PET‐RAFT Polymerization

Journal of Polymer Science, EarlyView.
The use of SI‐PET‐RAFT has been gaining momentum for producing thick, homogenous, functional polymer brushes, in an oxygen‐tolerant manner. However, the connection between irradiation wavelength and the brush height has not been clear. Herein, we systematically explore the effect of irradiation wavelength on the resulting brush properties, finding a ...
László Mérai, Khrystyna Rymsha, Jyoti Yadav, Christian W. Pester, Andreas Fery, Quinn A. Besford   +5 more
wiley   +1 more source

Homology Modeling and Expression of Recombinant NS5-RdRp Based on the Indonesian Local Strain of Dengue Virus for Anti-Dengue Drug Development

Progress in Microbes and Molecular Biology
This study aims to isolate the RNA-dependent RNA polymerase (RdRp) gene of the dengue virus (DENV) isolates from Indonesia, determine the serotype of the local DENV strain through homology modeling, and express the recombinant RdRp protein in ...
Toto Subroto, Ade Rizqi Ridwan Firdaus, Shinta Kusumawardani, Taufik Ramdani Tohari, Theresia Adventina Nababan, Wulan Pertiwi, Muhammad Fadhlillah, Sri Agung Fitri Kusuma, Yaya Rukayadi   +8 more
doaj   +1 more source

RNAi technology development for weed control: all smoke and no fire?

Pest Management Science, EarlyView.
Despite the potential of Spray‐Induced Gene Silencing in weed management several critical points such as molecular target, weed species of interest as well as delivery techniques need to be addressed. Abstract RNA interference (RNAi) technology, specifically Spray‐Induced Gene Silencing (SIGS), holds potential as an innovative approach for selective ...
Silvia Panozzo, Andrea Milani, Serena Bordignon, Laura Scarabel, Serena Varotto   +4 more
wiley   +1 more source

Flavivirus RNA-Dependent RNA Polymerase Interacts with Genome UTRs and Viral Proteins to Facilitate Flavivirus RNA Replication

Viruses, 2019
Flaviviruses, most of which are emerging and re-emerging human pathogens and significant public health concerns worldwide, are positive-sense RNA viruses. Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which
YanPing Duan, Miao Zeng, Bowen Jiang, Wei Zhang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, ShaQiu Zhang, YunYa Liu, Ling Zhang, YanLing Yu, Leichang Pan, Shun Chen, Anchun Cheng   +17 more
doaj   +1 more source

Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase

Acta Pharmaceutica Sinica B, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become one major threat to human population health. The RNA-dependent RNA polymerase (RdRp) presents an ideal target of antivirals, whereas nucleoside analogs inhibitor is hindered by the ...
Quanjie Li, Dongrong Yi, Xiaobo Lei, Jianyuan Zhao, Yongxin Zhang, Xiangling Cui, Xia Xiao, Tao Jiao, Xiaojing Dong, Xuesen Zhao, Hui Zeng, Chen Liang, Lili Ren, Fei Guo, Xiaoyu Li, Jianwei Wang, Shan Cen   +16 more
doaj  

Identification and characterisation of Zucchini yellow fleck virus and a novel Nepovirus from next‐generation sequencing of mixed virus infections in cucumbers (Cucumis sativus) from Crete

Annals of Applied Biology, EarlyView.
High‐throughput sequencing from cucumber leaf samples collected in Crete, Greece, revealed mixed infections including a cucumber‐infecting isolate of Zucchini yellow fleck virus and a novel nepovirus, provisionally named cucumber nepovirus A (CuNVA).
Anthony James, Nikoleta Kryovrysanaki, Christos Andronis, Polyxeni G. Pappi, Kriton Kalantidis, Konstantina Katsarou   +5 more
wiley   +1 more source

Spatial Perturbations within an RNA Promoter Specifically Recognized by a Viral RNA-Dependent RNA Polymerase (RdRp) Reveal That RdRp Can Adjust Its Promoter Binding Sites [PDF]

, 1999
Scott Stevenson Stawicki, C. Cheng Kao
openalex   +1 more source

Multi‐omics analysis reveals discordant proteome and transcriptome responses in larval guts of Frankliniella occidentalis infected with an orthotospovirus

Insect Molecular Biology, EarlyView.
Tomato spotted wilt virus modulated the abundance of gut proteins in larval thrips, most notably manifested as a predominant down‐regulation in first instar larvae. Gut‐expressed protein and cognate transcript abundance were moderately correlated across the tissue system; however, the virus effect varied widely at transcriptional and translational ...
Jinlong Han, Dorith Rotenberg
wiley   +1 more source

Origin and Evolution of RNA-Dependent RNA Polymerase

Frontiers in Genetics, 2017
RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias, Ariosvaldo P. dos Santos Junior, Thais G. Rêgo, Marco V. José   +3 more
doaj   +1 more source