Results 121 to 130 of about 53,016 (292)

Targeting the 3CLpro and RdRp of SARS-CoV-2 with phytochemicals from medicinal plants of the Andean Region: molecular docking and molecular dynamics simulations

Journal of Biomolecular Structure and Dynamics, 2020
Given the highly contagious nature of SARS-CoV-2, it has resulted in an unprecedented number of COVID-19 infected and dead people worldwide. Since there is currently no vaccine available in the market, the identification of potential drugs is urgently ...
Francisco Mosquera-Yuqui, N. López-Guerra, Eduardo A Moncayo-Palacio   +2 more
semanticscholar   +1 more source

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu, Zhifu Xing, Jiao Li, Tangbing Yang, Huan Wu, Qiangsheng Ge, Yanju Wang, Baoan Song, Runjiang Song   +8 more
wiley   +1 more source

Tuning Polyacrylate Composition to Recognize and Modulate Fluorescent Proteins

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Random hetero oligomers (RHOs) of defined compositions are synthesized and fractionated to identify the chemical design criteria (charge, length, hydrophobicity) required to achieve nanomolar binding to green fluorescent protein, resulting in >100% fluorescence increases.
Darwin C. Gomez, Swarnadeep Seth, Ronnie Mondal, Stephen J. Koehler, Jared G. Baker, Charles Plate, Ian C. Anderson, Mikayla R. Smith, Joey Gloriod, Morgan Gunter, Valerie V. Welborn, Sanket A. Deshmukh, C. Adrian Figg   +12 more
wiley   +2 more sources

Tomato marchitez virus, a new plant picorna-like virus from tomato related to tomato torrado virus [PDF]

A new virus was isolated from a tomato plant from the state of Sinaloa in Mexico. This plant showed symptoms locally known as `marchitez disease¿: severe leaf necrosis, beginning at the base of the leaflets, and necrotic rings on the fruits.
Dullemans, A.M., Heuvel, J.F.J.M., van den, Maris, P.C., Verbeek, M., Vlugt, R.A.A., van der   +4 more
core   +2 more sources

Identification of a novel dual-target scaffold for 3CLpro and RdRp proteins of SARS-CoV-2 using 3D-similarity search, molecular docking, molecular dynamics and ADMET evaluation

Journal of Biomolecular Structure and Dynamics, 2020
The new SARS-CoV-2 coronavirus is the causative agent of the COVID-19 pandemic outbreak that affected whole the world with more than 6 million confirmed cases and over 370,000 deaths.
A. Aouidate, A. Ghaleb, Samir CHTITA, Mohammed Aarjane, A. Ousaa, H. Maghat, A. Sbai, M. Choukrad, M. Bouachrine, T. Lakhlıfı   +9 more
semanticscholar   +1 more source

Dissecting the Cell‐Type‐Specific Response to an Emerging Tobamovirus in Tomato Reveals Cultivar‐Dependent Involvement of Brassinosteroid Signalling

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant viruses drive widespread crop epidemics, yet the host plant responses across different cell types, particularly how these responses are influenced by cultivars with varying genetic backgrounds, including the presence of resistance (R) genes, remain poorly understood. Using tomato brown rugose fruit virus (ToBRFV) and two tomato cultivars,
Yuhong Zhang, Shan Bu, Yuxin Nie, Luyou Wang, Jiayi Liu, Junchen Xu, Jiejun Peng, Fei Yan, Jian Wu   +8 more
wiley   +1 more source

Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication

Frontiers in Microbiology, 2018
Norovirus (NoV) is a leading cause of epidemic acute non-bacterial gastroenteritis, and replicates through virion protein genome-linked (VPg)-primed or de novo RNA synthesis by RNA-dependent RNA polymerase (RdRp).
Ji-Hye Lee, Beom Seok Park, Intekhab Alam, Kang R. Han, Scott B. Biering, Soo J. Kim, Jayoung Choi, Jong H. Seok, Mi S. Chung, Ho M. Kim, Seungmin Hwang, Seungmin Hwang, Kyung H. Kim   +12 more
doaj   +1 more source

Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures

Nature Communications, 2020
During translocation by viral RNA-dependent RNA polymerases (RdRP), the template-product RNA duplex moves in an asymmetric manner. Here the authors describe several crystal structures of RdRP translocations intermediates that, along with enzymological ...
Meihua Wang, Rui Li, Bo Shu, Xuping Jing, Han-Qing Ye, Peng Gong   +5 more
doaj   +1 more source

Metagenomic-based Surveillance of Pacific Coast tick Dermacentor occidentalis Identifies Two Novel Bunyaviruses and an Emerging Human Ricksettsial Pathogen. [PDF]

, 2017
An increasing number of emerging tick-borne diseases has been reported in the United States since the 1970s. Using metagenomic next generation sequencing, we detected nucleic acid sequences from 2 novel viruses in the family Bunyaviridae and an emerging ...
Bouquet, Jerome, Chiu, Charles Y, Delwart, Eric, Lane, Robert S, Melgar, Michael, Swei, Andrea   +5 more
core   +2 more sources

RNA‐dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID‐19

Cancer Science, 2020
A recent outbreak of coronavirus disease (COVID‐19) caused by the novel severe acute respiratory syndrome coronavirus 2 has driven a global pandemic with catastrophic consequences.
M. Machitani, Mami Yasukawa, Jotaro Nakashima, Y. Furuichi, K. Masutomi   +4 more
semanticscholar   +1 more source