Results 141 to 150 of about 53,016 (292)

Ultra‐High Molecular Weight 21‐Arm Star‐Shaped Polyacrylates via Cu(0)‐RDRP

Macromolecular Chemistry and Physics, Volume 227, Issue 3, 16 February 2026.
UHMW 21‐arm star polyacrylates are synthesized in a facile manner via Cu(0) wire‐RDRP, using a β‐cyclodextrin‐derived initiator, exhibiting low dispersity and limited star‐star coupling. End‐group fidelity is verified through in situ chain extension, while the rigid core and UHMW allow for TEM imaging of individual stars without staining.
Maciej Ratajczyk, Arkadios Marathianos, Alexandros Magiakos, Paul Wilson, David M. Haddleton, Evelina Liarou   +5 more
wiley   +1 more source

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]

, 2019
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna, Liu, Jisheng, Smagghe, Guy, Swevers, Luc   +3 more
core   +1 more source

A Novel Crustavirus as a Candidate Aetiology of Tail Fan Necrosis in New Zealand Red Rock Lobsters, Jasus edwardsii

Journal of Fish Diseases, Volume 49, Issue 2, February 2026.
ABSTRACT Tail fan necrosis (TFN) is a shell disease affecting spiny lobsters' outer integument, with significant implications for the health and commercial viability of red rock lobsters (Jasus edwardsii) in New Zealand. Despite its impact, the potential role of a microbial agent in TFN remains poorly understood.
Rebecca M. Grimwood, Leonardo N. Zamora, Jessica A. Darnley, Lizenn Delisle, Kate S. Hutson, Julie Hills, Jemma L. Geoghegan   +6 more
wiley   +1 more source

An Improved Description of the Small RNA Landscape of the Human Fungal Pathogen Aspergillus fumigatus

Molecular Microbiology, Volume 125, Issue 2, Page 133-144, February 2026.
The mechanisms of small RNA biogenesis in fungi are diverse and multifactorial. Here, we provide an improved understanding of the processing of double‐stranded RNA in the human fungal pathogen Aspergillus fumigatus, revealing susceptibility to high levels of double‐stranded RNA and limited input of the canonical RNAi machinery on the endogenous small ...
Xiaoqing Pan, Abdulrahman A. Kelani, Lukas Schrettenbrunner, Swatika Prabakar, Bhawana Israni, Matthew G. Blango   +5 more
wiley   +1 more source

Interference of small compounds and Mg2+ with dsRNA-binding fluorophores compromises the identification of SARS-CoV-2 RdRp inhibitors

Scientific Reports
The COVID-19 pandemic highlighted the need for the rapid development of antiviral therapies. Viral RNA-dependent RNA polymerases (RdRp) are promising targets, and numerous virtual screenings for potential inhibitors were conducted without validation of ...
Susana Llanos, Bruno Di Geronimo, Ester Casajús, Elena Blanco-Romero, Rafael Fernández-Leiro, Juan Méndez   +5 more
doaj   +1 more source

Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II

Frontiers in Microbiology, 2018
Noroviruses are the leading cause of viral gastroenteritis in humans across the world. RNA-dependent RNA polymerase (RdRp) plays a critical role in the replication of the viral genome.
Keita Ozaki, Keita Ozaki, Yuki Matsushima, Koo Nagasawa, Takumi Motoya, Akihide Ryo, Makoto Kuroda, Kazuhiko Katayama, Hirokazu Kimura, Hirokazu Kimura   +9 more
doaj   +1 more source

Mapping of transcription termination within the S segment of SFTS phlebovirus facilitated the generation of NSs-deletant viruses [PDF]

, 2017
SFTS phlebovirus (severe fever with thrombocytopenia syndrome virus; SFTSV) is an emerging tick-borne bunyavirus that was first reported in China in 2009. Here we report the generation of a recombinant SFTSV (rHB29NSsKO) that cannot express the viral non-
Brennan, Benjamin, Elliott, Richard M., Rezelj, Veronica V.   +2 more
core   +1 more source

A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro

PLoS Comput. Biol., 2020
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus poses serious threats to the global public health and leads to worldwide crisis. No effective drug or vaccine is readily available.
Haiping Zhang, Yang Yang, Junxin Li, Min Wang, Konda Mani Saravanan, Jinli Wei, Justin Tze-Yang Ng, Md Tofazzal Hossain, Maoxuan Liu, Huiling Zhang, X. Ren, Yi Pan, Yin Peng, Yi Shi, X. Wan, Yingxia Liu, Yanjie Wei   +16 more
semanticscholar   +1 more source

NeoRdRp2 with improved seed data, annotations, and scoring

Frontiers in Virology
RNA-dependent RNA polymerase (RdRp) is a marker gene for RNA viruses; thus, it is widely used to identify RNA viruses from metatranscriptome data. However, because of the high diversity of RdRp domains, it remains difficult to identify RNA viruses using ...
Shoichi Sakaguchi, Takashi Nakano, So Nakagawa, So Nakagawa, So Nakagawa   +4 more
doaj   +1 more source

DYNAMICS OF COVID-19 SYMPTOMS AND CHANGES IN Ct VALUES OF RdRp, N AND E GENES IN 1044 PATIENTS POSITIVE FOR SARS-CoV-2 [PDF]

, 2022
Mariya Sredkova, Cvetan Popov, Georgi Golemanov, Pencho Tonchev, Vladislav Nankov, Alexander Blazhev, Antoniya Popova, Radostina Mogilska, Valeri Delcheva, Eleonora Kuteva   +9 more
openalex   +1 more source