Role of reactive nitrogen species in male infertility [PDF]
Reproductive Biology and Endocrinology, 2012 Reactive nitrogen species (RNS) is a subset of free oxygen radicals called reactive oxygen species (ROS). Physiological levels of ROS are necessary to maintain the reproductive functions such as cell signaling, tight junction regulation, production of ...
Doshi Sejal B +3 more
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Bioenergetics and Reactive Nitrogen Species in Bacteria. [PDF]
Int J Mol Sci, 2022 The production of reactive nitrogen species (RNS) by the innate immune system is part of the host’s defense against invading pathogenic bacteria. In this review, we summarize recent studies on the molecular basis of the effects of nitric oxide and peroxynitrite on microbial respiration and energy conservation.
Borisov VB, Forte E.
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Switching Reactive Oxygen Species into Reactive Nitrogen Species by Photocleaved O2‐Released Nanoplatforms Favors Hypoxic Tumor Repression [PDF]
Advanced Science, 2021 In various reactive oxygen species (ROS)‐based antitumor approaches (e.g., photodynamic therapy), increasing attentions are made to improve ROS level, but the short lifetime that is another decisive hurdle of ROS‐based antitumor outcomes is not even ...
Tao Luo +12 more
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Reactive nitrogen species in cellular signaling. [PDF]
Exp Biol Med (Maywood), 2015 The transduction of cellular signals occurs through the modification of target molecules. Most of these modifications are transitory, thus the signal transduction pathways can be tightly regulated. Reactive nitrogen species are a group of compounds with different properties and reactivity.
Adams L, Franco MC, Estevez AG.
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Reactive nitrogen species in host-bacterial interactions. [PDF]
Curr Opin Immunol, 2019 Reactive nitrogen species play diverse and essential roles in host-pathogen interactions. Here, we review selected recent discoveries regarding nitric oxide (NO) in host defense and the pathogenesis of infection, mechanisms of bacterial NO resistance, production of NO by human macrophages, NO-based antimicrobial therapeutics and NO interactions with ...
Fang FC, Vázquez-Torres A.
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Modification of DNA structure by reactive nitrogen species as a result of 2-methoxyestradiol–induced neuronal nitric oxide synthase uncoupling in metastatic osteosarcoma cells [PDF]
Redox Biology, 2020 2-methoxyestradiol (2-ME) is a physiological anticancer compound, metabolite of 17β-estradiol. Previously, our group evidenced that from mechanistic point of view one of anticancer mechanisms of action of 2-ME is specific induction and nuclear hijacking ...
Magdalena Gorska-Ponikowska +14 more
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Reactive Oxygen and Nitrogen Species in Plants
AntioxidantsReactive oxygen and nitrogen species (ROS and RNS) include two families of molecules that, in recent years, have been shown to be involved in a wide range of biological functions, such as seed and pollen germination, the development and regulation of ...
Francisco J Corpas, José M. Palma
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Effects of aluminum on metabolism of reactive oxygen species and reactive nitrogen species in root tips of different Eucalyptus species [PDF]
BMC Plant BiologyOn acidified soil, the growth of Eucalyptus is seriously restricted by aluminum (Al) stress. Therefore, breeding Eucalyptus species with excellent Al tolerance, developing the genetic potential of species, and improving tolerance to Al stress are ...
Zilong Ouyang +4 more
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Targeting reactive nitrogen species suppresses hereditary pancreatic cancer. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance Germline mutations of BRCA2 associate with tissue-specific cancers, such as familial pancreatic cancer. However, it is unclear why BRCA2 mutation causes tissue-specific cancer. Here, we show that pancreas-specific reactive nitrogen species (RNS) causes oxidative damage and DNA double-strand breaks.
Li M, Chen Q, Ma T, Yu X.
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Quercetin’s Effects on Glutamate Cytotoxicity
Molecules, 2022 The potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease ...
Kade Riche, Natalie R. Lenard
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