Results 61 to 70 of about 548,863 (305)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Oxidative stress, aging, and diseases
Clinical Interventions in Aging, 2018 Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences ...
Liguori I +10 more
doaj
Advances in Redox Research, 2022 The free radicals along with several reactive oxygen species (ROS) and reactive nitrogen species (RNS) are known to play a dual role in the biological living system which carries a substantial importance in terms of signal networking in plants.
Mamun Mandal +8 more
doaj +1 more source
Reactive Nitrogen Species-Dependent Effects on Soybean Chloroplasts [PDF]
Plant Signaling & Behavior, 2007 Nitric oxide (NO) generation by soybean (Glycine max, var ADM 4800) chloroplasts was studied by electron paramagnetic resonance (EPR) spin-trapping technique.1 Both nitrite and L-arginine (arg) are the required substrates for enzymatic activities considered as possible sources of NO in plants.
Susana, Puntarulo +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Silver nanoparticles can attenuate nitrative stress
Redox Biology, 2017 We have reported previously that glucose availability can modify toxicity of silver nanoparticles (AgNPs) via elevation of antioxidant defence triggered by increased mitochondrial generation of reactive oxygen species.
Mariusz Zuberek +3 more
doaj +1 more source
Frontiers in Plant Science, 2020 Nitration of diverse biomolecules, including proteins, lipids and nucleic acid, by reactive nitrogen species represents one of the key mechanisms mediating nitric oxide (NO) biological activity across all types of organisms.
Marek Petřivalský, Lenka Luhová
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Recent advances of antioxidant low-dimensional carbon materials for biomedical applications
Frontiers in Bioengineering and Biotechnology, 2023 As the primary cause of many tissue damage and diseases, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well known to be extremely harmful to a variety of biological components in cells including lipids, proteins and DNA.
Nan Tang +6 more
doaj +1 more source