Results 21 to 30 of about 1,286,655 (192)

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 [PDF]

, 2014
The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear.
Billen, Johan, Braeckman, Bart, De Haes, Wouter, Depuydt, Geert, Frooninckx, Lotte, Schoofs, Liliane, Smolders, Arne, Temmerman, Liesbet, Van Assche, Roel   +8 more
core   +1 more source

High Serum-Induced AhRL Is Associated with Prevalent Metabolic Syndrome and Future Impairment of Glucose Tolerance in the Elderly [PDF]

Endocrinology and Metabolism, 2021
Background High circulating levels of dioxins and dioxin-like chemicals, acting via the aryl hydrocarbon receptor (AhR), have previously been linked to diabetes.
Youngmi Kim Pak, Hoon Sung Choi, Wook Ha Park, Suyeol Im, P. Monica Lind, Lars Lind, Hong Kyu Lee   +6 more
doaj   +1 more source

Reactive oxygen species and Covid-19

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2020
No ...
Dwi Nur Ahsani
doaj   +1 more source

Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. [PDF]

, 2010
Oxidative stress is common in inflammatory processes associated with many diseases including Chagas' disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant ...
Arantes, Jerusa Marilda, Araújo, Márcio Sobreira Silva, Carneiro, Cláudia Martins, de Abreu Vieira, Paula Melo, Elói-Santos, Silvana Maria, Francisco, Amanda Fortes, Martins-Filho, Olindo Assis, Pedrosa, Maria Lúcia, Silva, Maisa, Tafuri, Washington Luiz, Teixeira-Carvalho, Andréa   +10 more
core   +2 more sources

Cell Morphology, Viability, Osteocalcin Activity, and Alkaline Phosphatase Activity in Milled versus Unmilled Surface of the Femoral Head

Journal of Orthopaedic Surgery, 2016
Purpose To evaluate cellular activity in milled versus unmilled surface of the femoral head in 21 patients who underwent robot-assisted total hip arthroplasty (THA). Methods The femoral head of 21 consecutive patients who underwent robot-assisted THA for
Kee Hyung Rhyu, Chang Hoon Cho, Kyung Sik Yoon, Young Soo Chun   +3 more
doaj   +1 more source

Oxidative stress and muscle homeostasis [PDF]

, 2010
Purpose of review The term oxidative stress is often used to indicate a condition in which the accumulation of reactive oxygen species is considered just damaging.
Fanò, Giorgio, Fulle, Stefania, Musarò, Antonio   +2 more
core   +1 more source

Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. [PDF]

, 2015
Mitochondrial dysfunction has been implicated in human diseases, including cancer, and proposed to accelerate aging. The Drosophila Cyclin-dependent protein kinase complex cyclin D/cyclin-dependent kinase 4 (CycD/Cdk4) promotes cellular growth by ...
de la Cruz, Aida Flor A, Edgar, Bruce A, Icreverzi, Amalia, Walker, David W   +3 more
core   +1 more source

Granzymes in health and diseases: the good, the bad and the ugly

Frontiers in Immunology
Granzymes are a family of serine proteases, composed of five human members: GA, B, H, M and K. They were first discovered in the 1980s within cytotoxic granules released during NK cell- and T cell-mediated killing.
Lavinia Cigalotto, Lavinia Cigalotto, Denis Martinvalet, Denis Martinvalet   +3 more
doaj   +1 more source

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis. [PDF]

, 2018
OBJECTIVE: Cigarette smoke exposure (CSE) is a risk factor for cerebral aneurysm (CA) formation, but the molecular mechanisms are unclear. Although CSE is known to contribute to excess reactive oxygen species generation, the role of oxidative stress on ...
Ali, Muhammad S., Chalouhi, Nohra, Ding, Dale, Dumont, Aaron S., Hare, Joshua M., Hasan, David M., Jabbour, Pascal, Martinez Lege, Alejandra, Owens, Gary K, Pascale, Crissey L., Starke, Robert M., Thompson, John W., Toborek, Michal   +12 more
core   +2 more sources

Generation of superoxide and singlet oxygen from α-tocopherolquinone and analogues. [PDF]

, 2007
Three potential routes to generation of reactive oxygen species from a tocopherolquinone have been identified. The quinone of the water-soluble vitamin E analogue Trolox C (Trol-Q) is reduced by hydrated electron and isopropanol a hydroxyalkyl radical ...
Bisby, RH, Crisostomo, AG, Moreno, RB, Navaratnam, S, Wilkinson, JA   +4 more
core   +1 more source