Results 41 to 50 of about 4,033,233 (224)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Does it matter if some learners read slowly? Exploring relationships between reading comprehension and oral reading fluency

South African Journal of Childhood Education
Background: Although Zimbabwe has performed quite well on Grade 6 SACMEQ literacy assessments compared to other African countries, reading levels are generally low and there is little research on reading literacy in Zimbabwean primary schools.
Fungai Mutema, Elizabeth J. Pretorius
doaj   +1 more source

Reading Self-Concept and Reading Anxiety in Second Grade Children: The Roles of Word Reading, Emergent Literacy Skills, Working Memory and Gender

Frontiers in Psychology, 2018
Background: Most studies in the field of reading have focused on the linguistic and cognitive factors. Less is known about the affective aspects of reading in young readers, such as self-perceptions of reading, and reading anxiety.Aims: This study aimed ...
Tami Katzir, Young-Suk G. Kim, Shahar Dotan   +2 more
doaj   +1 more source

Morphosyntactic Skills Influence the Written Decoding Accuracy of Italian Children With and Without Developmental Dyslexia

Frontiers in Psychology, 2022
Some types of developmental dyslexia (DD) are associated with morphology. Deep DD leads to morphological and semantic errors, and possible comorbidity with syntactic deficits; phonological-output-buffer DD causes problems in decoding longer ...
Emanuele Casani, Mila Vulchanova, Anna Cardinaletti   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The 4M (Look-Organize-Spell-Read) Intervention to Improve Reading Accuracy in Slow Learners: A Single-Case Study

Gadjah Mada Journal of Professional Psychology
This single-case study aimed to evaluate the effectiveness of the 4M intervention in improving reading accuracy among slow learners with reading challenges.
Isnaini Rakhmi Khoirunnisa Massitoh, Haryanta Haryanta   +1 more
doaj   +1 more source

The relationship between visual memory of non-words and accuracy and rate reading among female first-graders living in Isfahan-Iran

مجله پژوهش در علوم توانبخشی, 2011
Introduction: Reading accuracy depends on such skills as normal hearing, auditory perception, auditory memory, normal visual perception and visual memory. The aim of this study was to determine the relationship between two reading skills, namely accuracy
Nahid Baharlooie, Saghar GHolami, Maede SHariat, Mitra Nikzad   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Systematic reviews of diagnostic test accuracy

, 2008
More and more systematic reviews of diagnostic test accuracy studies are being published, but they can be methodologically challenging. In this paper, the authors present some of the recent developments in the methodology for conducting systematic ...
JJ Deeks, Cochrane Diagnostic Test Accuracy Working Group, C. Gatsonis, RUTJES, ANNE WILHELMINA SASKIA, D'AMICO, Roberto, MM Leeflang, PM Bossuyt   +6 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source