Results 191 to 200 of about 23,695,477 (235)

A strategy to increase rebaudioside A content based on one-step bioconversion of Stevia extract to steviol

Green Chemistry, 2023
Steviol glycosides are natural sweeteners extracted from Stevia rebaudiana that have been applied in food for many years.
Yu Lin, Manman Wen, Qing Lan, Yuansong Yin, Ribo Huang, Hao Pang, Hang Wei, L. Du   +7 more
semanticscholar   +1 more source

Rebaudioside F, a diterpene glycoside from Stevia rebaudiana

Phytochemistry, 2002
The sweet diterpenoid glycoside, rebaudioside F, was isolated from leaves of a high rebaudioside C producing line of Stevia rebaudiana, and its structure was established by chemical and spectral studies.
Alvin N, Starratt, Christopher W, Kirby, Robert, Pocs, James E, Brandle   +3 more
openaire   +2 more sources

Modeled structure-based computational redesign of a glycosyltransferase for the synthesis of rebaudioside D from rebaudioside A

Biochemical Engineering Journal, 2020
Abstract Engineering of enzymes without crystal structures and homologous structures is a great challenge for structure-based computational enzyme design. In this study, a computational strategy that combines protein structure prediction, sequence optimization, and molecular dynamics simulation was developed to improve the catalytic efficiency of the
Min Lin, Fei Wang, Yushan Zhu
openaire   +1 more source

Highly efficient synthesis of mono-β-1,6-Glucosylated Rebaudioside A derivative catalyzed by glycosyltransferase YjiC.

Carbohydrate Research, 2022
Steviol glycosides have attracted great interest because of their high levels of sweetness and safety, and absence of calories. Improvement of their sensory qualities via glycosylation modification by glycosyltransferase is a research hotspot.
Lifeng Yang, Qian Ping, Zhenbo Yuan, Jiejuan Jiang, Baodang Guo, Changmei Liu, Y. Rao, Jinsong Shi, Yan Zhang   +8 more
semanticscholar   +1 more source

Genotoxicity studies on a high-purity rebaudioside A preparation

Food and Chemical Toxicology, 2009
Rebaudioside A (Reb A) is a steviol glycoside isolated from the leaves of the Stevia rebaudiana plant. This non-nutritive, natural sweetener is reported to be 250-450 times sweeter than sucrose and has potential for wide use in the US diet, and is used in Japan and South America today.
Lonnie D, Williams, George A, Burdock
openaire   +2 more sources

Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system.

Toxicology and Applied Pharmacology, 2021
Hesperetin (HSP) has excellent biological activities with poor water solubility which limits its clinical development. In this study, we successfully prepared a novel, self-assembled micelle based on Rebaudioside A (RA) for oral delivery of HSP with ...
Jun Wang, Qiqi Li, Zekun Chen, Xianghui Qi, Xianggen Wu, Guohu Di, Junting Fan, Chuan-Yong Guo   +7 more
semanticscholar   +1 more source

Photostability of Rebaudioside A and Stevioside in Beverages

Journal of Agricultural and Food Chemistry, 2008
The Coca-Cola Company and Cargill, Inc. have initiated the development and commercialization of the Stevia rebaudiana (Bertoni) derived sweetener rebaudioside A. Efforts were focused on high purity rebaudioside A (>97% by HPLC), commonly known as rebiana. In the course of the development program, extensive stability studies were carried out on rebiana,
John F, Clos, Grant E, DuBois, Indra, Prakash   +2 more
openaire   +2 more sources

Synthesis and characterization of sodium alginate/poly(N-vinylpyrrolidone) nano-carrier loaded with rebaudioside A and/or stevioside for anticancer drug delivery.

International Journal of Biological Macromolecules
Stevioside and rebaudioside A revealed anticancer effects against diversity of cancers, such as colon, breast and liver cancers. Rebaudioside A can trigger apoptosis in cancer cells via activation of caspase-dependent pathway.
Shaymaa M. Mohamed, Ahmad K B Aljohani, Ahmed El-morsy, Rwaida A Al Haidari, Mshref A.A. Alamri, Yahya A. Maqnas, Aishah M. Alsibaee, M. A. Mostafa, D. E. Keshek, M. Mohamed, Soad A. L. Bayoumi, Samir A. Salama, Khaled El‐Adl   +12 more
semanticscholar   +1 more source

Safety evaluation of rebaudioside A produced by fermentation

Food and Chemical Toxicology, 2016
The safety of rebaudioside A, produced fermentatively by Yarrowia lipolytica encoding the Stevia rebaudiana metabolic pathway (fermentative Reb A), is based on several elements: first, the safety of steviol glycosides has been extensively evaluated and an acceptable daily intake has been defined; second, the use of Y.
Mélina Rumelhard, Hiromi Hosako, Irene M.J. Eurlings, Walter M.A. Westerink, Lauren M. Staska, Jeanine A.G. van de Wiel, James La Marta   +6 more
openaire   +2 more sources

In vitro metabolism of rebaudioside B, D, and M under anaerobic conditions: Comparison with rebaudioside A

Regulatory Toxicology and Pharmacology, 2014
The hydrolysis of the steviol glycosides rebaudioside A, B, D, and M, as well as of steviolbioside (a metabolic intermediate) to steviol was evaluated in vitro using human fecal homogenates from healthy donors under anaerobic conditions. Incubation of each of the rebaudiosides resulted in rapid hydrolysis to steviol. Metabolism was complete within 24h,
Sidd, Purkayastha, George, Pugh, Barry, Lynch, Ashley, Roberts, David, Kwok, Stanley M, Tarka   +5 more
openaire   +2 more sources