Results 171 to 180 of about 119,693 (290)

Chronic Therapy With a Partial Adenosine A1-Receptor Agonist Improves Left Ventricular Function and Remodeling in Dogs With Advanced Heart Failure

Circulation: Heart Failure, 2013
H. Sabbah, Ramesh C. Gupta, Smita Kohli, Mengjun Wang, S. Rastogi, Kefei Zhang, K. Zimmermann, Nicole Diedrichs, Barbara E. Albrecht-Küpper   +8 more
semanticscholar   +1 more source

Effects of acute selective cyclooxygenase‐2 inhibition on skeletal muscle microvascular oxygenation and exercise tolerance

Experimental Physiology, EarlyView.
Abstract The cyclooxygenase (COX) pathway regulates vascular tone and, therefore, local O2 delivery‐utilization matching. The two main isoforms, COX‐1 and COX‐2, may promote opposing effects on contracting muscle O2 transport in health by inducing vasoconstriction and vasodilatation, respectively.
Michael D. Belbis, Michael J. Holmes, Joseph Yao, Christopher W. Kinnick, Christopher K. Kargl, Carly Day, Nicole L. Noel, Timothy P. Gavin, Bruno T. Roseguini, Daniel M. Hirai   +9 more
wiley   +1 more source

Asymmetric Synthesis of Noradamantane Scaffolds via Diphenylprolinol Silyl Ether‐Mediated Domino Michael/Epimerization/Michael (or Aldol)/1,2‐Addition Reactions

Angewandte Chemie, Volume 137, Issue 23, June 2, 2025.
Topologically unique, 3D cage‐like noradamantanes are synthesized in one pot from simple starting materials. Catalyzed by diphenylprolinol silyl ether, the reaction followed a domino sequence of Michael/epimerization/Michael/1,2‐addition, achieving excellent enantioselectivity.
Konstantinos Daskalakis, Nariyoshi Umekubo, Satrajit Indu, Genki Kawauchi, Tohru Taniguchi, Kenji Monde, Yujiro Hayashi   +6 more
wiley   +2 more sources

TRPV1 blockade restores the baroreflex control of renal sympathetic nerve activity in cisplatin‐induced renal injury in rats

Experimental Physiology, EarlyView.
Abstract Renal injury is associated with inflammatory responses within the kidney which could involve activation of transient receptor potential vanilloid 1 (TRPV1) channels. This study investigated whether TRPV1 channels modulate baroreflex regulation of renal sympathetic nerve activity (RSNA) in a rat model of cisplatin‐mediated renal injury.
Mohammed H. Abdulla, Ella Murphy, Lauren Mulcahy, Edward J. Johns   +3 more
wiley   +1 more source

Adenosine A1 receptor regulates osteoclast formation by altering TRAF6/TAK1 signaling

Purinergic Signalling Purinergic Signalling, 2012
W. He, B. Cronstein
semanticscholar   +1 more source

A human skeletal muscle cross‐bridge model to characterize the role of metabolite accumulation in muscle fatigue

Experimental Physiology, EarlyView.
Abstract Skeletal muscle fatigue is accompanied by the accumulation of metabolites, such as adenosine diphosphate (ADP), inorganic phosphate (Pi), and protons (H+). However, we lack a comprehensive understanding of the contribution of these metabolic changes to the development of muscle fatigue during intense exercise and the underlying mechanisms.
John I. Hendry, Muhammet Enes Erol, Gwenael Layec, Edward P. Debold, Shivendra G. Tewari, Anders Wallqvist, Venkat R. Pannala   +6 more
wiley   +1 more source

Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones

Development, 2012
O. Stettler, R. Joshi, A. Wizenmann, J. Reingruber, D. Holcman, C. Bouillot, F. Castagner, A. Prochiantz, K. L. Moya   +8 more
semanticscholar   +1 more source

Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez, Leigh E. Wicki‐Stordeur, Annika V. Ariano, Leigh Anne Swayne   +3 more
wiley   +1 more source

Partial adenosine A1 receptor agonists for cardiovascular therapies

Purinergic Signalling Purinergic Signalling, 2012
Barbara E. Albrecht-Küpper, K. Leineweber, P. Nell   +2 more
semanticscholar   +1 more source

Adaptations to hypoxia in the vertebrate retina

The Journal of Physiology, EarlyView.
Abstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Michael G. Jonz
wiley   +1 more source