Results 1 to 10 of about 271,431 (312)

Decoding Angiotensin Receptors: TOMAHAQ‐Based Detection and Quantification of Angiotensin Type‐1 and Type‐2 Receptors

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The renin‐angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G‐protein–coupled receptors, the angiotensin type‐1 and type‐2 receptors, in almost every organ.
Caglar Cosarderelioglu, Simion Kreimer, Alma I. Plaza‐Rodriguez, Pablo A. Iglesias, C. Conover Talbot, Helmy M. Siragy, Robert M. Carey, Ceereena Ubaida‐Mohien, Brian O'Rourke, Luigi Ferrucci, David A. Bennett, Jeremy Walston, Peter Abadir   +12 more
doaj   +3 more sources

Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis [PDF]

Kidney Research and Clinical Practice, 2023
Background Angiotensin II induces glomerular and podocyte injury via systemic and local vasoconstrictive or non-hemodynamic effects including oxidative stress. The release of reactive oxygen species (ROS) from podocytes may participate in the development
Tae-Sun Ha, Su-Bin Seong, Dong-Soo Ha, Seung Jung Kim   +3 more
doaj   +1 more source

Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling. [PDF]

, 2014
Pendrin is a Cl-/HCO3- exchanger expressed in the apical regions of renal intercalated cells. Following pendrin gene ablation, blood pressure falls, in part, from reduced renal NaCl absorption.
Bonsall, Robert, Eaton, Douglas C, El-Ali, Alexander M, Gleason, Rudolph L, Hansen, Laura, Hong, Seongun, Kim, Young Hee, Ma, Jing, Pech, Vladimir, Pham, Truyen D, Ramosevac, Semra, Sutliff, Roy L, Verlander, Jill W, Walker, Lori A, Wall, Susan M, Walp, Erik R   +15 more
core   +11 more sources

Angiotensin Type 2 Receptor-Mediated Hypotension in Angiotensin Type-1 Receptor-Blocked Rats [PDF]

Hypertension, 2001
The type-2 (AT 2 ) angiotensin (Ang) II receptor has been characterized as potentially counterregulatory to the actions of Ang II at its type-1 (AT 1 ) receptor. We investigated the effects of Ang II and CGP-42112A (CGP), a selective peptide AT
R M, Carey, N L, Howell, X H, Jin, H M, Siragy   +3 more
openaire   +2 more sources

Angiotensin-[1-12] interacts with angiotensin type I receptors [PDF]

Neuropharmacology, 2014
Angiotensin-(1-12) [Ang-(1-12)], a newer member of angiotensin peptides, is proposed to be converted enzymatically to angiotensin I (Ang I) and to angiotensin II (Ang II); the latter being the bioactive peptide. We studied the Ang-(1-12) and Ang II responses in COS-7 cells or CHO cells transfected with 5 μg AT1R by monitoring [Ca(2+)]i using the Fluo-4.
Chan, King Hang, Chen, Yi Hung, Zhang, Ying, Wong, Yung Hou, Dun, Nae J.   +4 more
openaire   +3 more sources

Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?

Molecular Medicine, 2020
Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/
Pawel Namsolleck, Gert N. Moll
doaj   +1 more source

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor–Mediated Cardiomyocyte Autophagy [PDF]

Hypertension, 2009
Autophagy has emerged as an important process in the pathogenesis of cardiovascular diseases, but the proximal triggers for autophagy are unknown. Angiotensin II plays a central role in the pathogenesis of cardiac hypertrophy and heart failure. In this study, we used angiotensin II type 1 (AT 1 ) and type 2 (AT
Porrello, Enzo R., D'Amore, Angelo, Curl, Claire L., Allen, Andrew M., Harrap, Stephen B., Thomas, Walter G., Delbridge, Lea M. D.   +6 more
openaire   +3 more sources

Advances in the allostery of angiotensin II type 1 receptor

Cell & Bioscience, 2023
Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of high ...
Xi Zhang, Suli Zhang, Meili Wang, Hao Chen, Huirong Liu   +4 more
doaj   +1 more source

Angiotensin Type 2 Receptor Stimulation Ameliorates Left Ventricular Fibrosis and Dysfunction via Regulation of Tissue Inhibitor of Matrix Metalloproteinase 1/Matrix Metalloproteinase 9 Axis and Transforming Growth Factor β1 in the Rat Heart [PDF]

, 2014
Left ventricular (LV) remodeling is the main reason for the development of progressive cardiac dysfunction after myocardial infarction (MI). This study investigated whether stimulation of the angiotensin type 2 receptor is able to ameliorate
Dahlöf, Bjorn, Hallberg, Anders, Kaschina, Elena, Kintscher, Ulrich, Lauer, Dilyara, Sharkovska, Yuliya, Slavic, Svetlana, Sommerfeld, Manuela, Steckelings, Ulrike Muscha, Thöne-Reineke, Christa, Unger, Thomas   +10 more
core   +7 more sources

Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?

Frontiers in Pharmacology, 2020
G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved and clinical prescribed drugs and represent the largest and most structurally diverse family of transmembrane signaling proteins, with almost 1000 members ...
Natalia L. Rukavina Mikusic, Mauro G. Silva, Angélica M. Pineda, Mariela M. Gironacci   +3 more
doaj   +1 more source