Results 11 to 20 of about 271,431 (312)

Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling [PDF]

, 2014
The renin angiotensin system (RAS) is integral to cardiovascular physiology, however, dysregulation of this system largely contributes to the pathophysiology of cardiovascular disease (CVD).
Akishita, Barroso, Booz, Bosnyak, Bosnyak, Brosnihan, Bruneval, Bryan, Calo, Campbell, Caroline Fattah, Castro, Chappell, Chappell, Chen, Christopher M. Loughrey, Clare A. McKinney, Clarke, Costa, Crackower, Cushman, De Mello, Dias-Peixoto, Domeier, Dong, Donoghue, Donoghue, Drummer, Faria-Silva, Ferreira, Ferreira, Ferreira, Ferreira, Flores-Munoz, Flores-Munoz, Fomovsky, Fraga-Silva, Fraga-Silva, Freeman, Galis, Gava, Gembardt, Gomes, Graeme Milligan, Grobe, Gusev, Hanke, Hannan, Harmer, Heitsch, Horiguchi, Horiuchi, Hunyady, Inaba, Iwata, Jackman, Jaiswal, Jarajapu, Kaminska, Kassiri, Katada, Kokkonen, Kramkowski, Langeveld, Lautner, Liao, Libby, Liu, Loot, Lovren, Masson, McCollum, Mehta, Mercure, Miura, Mogielnicki, Nakajima, Newby, Ng, Nouet, Ocaranza, Ocaranza, Ocaranza, Patel, Patel, Qi, Ray, Rice, Rodgers, Rodrigues-Machado, Ross, Rowe, Sampaio, Sampaio, Santos, Santos, Schultz Jel, Selvetella, Shah, Sheng-Long, Singh, Sluimer, Stegbauer, Strawn, Stuart A. Nicklin, Tallant, Tesanovic, Tipnis, Turner, Uekama, Varagic, Vickers, Vilas-Boas, Walters, Wang, Weber, West, Wiemer, Yamada, Yang, Zeng, Zhang, Zhao, Zhong   +123 more
core   +1 more source

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li‐Juan Min, Hui‐Yu Bai, Bao‐Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan‐no, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi   +12 more
doaj   +1 more source

Angiotensin II modulates THP-1-like macrophage phenotype and inflammatory signatures via angiotensin II type 1 receptor

Frontiers in Cardiovascular Medicine, 2023
Angiotensin II (Ang II) is a major component of the renin–angiotensin or renin–angiotensin–aldosterone system, which is the main element found to be involved in cardiopathology.
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal   +7 more
doaj   +1 more source

Angiotensin II Type 1 Receptor Blockers [PDF]

Circulation, 2001
In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1 2 Thereafter, the development of pharmacological probes that ...
openaire   +2 more sources

A novel mechanism of action for angiotensin-(1-7) via the angiotensin type 1 receptor [PDF]

, 2016
No abstract ...
Nicklin, Stuart A.
core   +1 more source

ANGIOTENSIN II RECEPTOR TYPE 1 EXPRESSION IN PATIENTS WITH MULTIFOCAL ATHEROSCLEROSIS

Российский кардиологический журнал, 2016
Local expression of rennin-angiotensin system (RAS) components significantly increases in patients with arterial hypertension and atherosclerosis with or without elevation of RAS activity in the blood.
I. S. Mykhailichenko
doaj   +1 more source

Divergent Spatiotemporal Interaction of Angiotensin Receptor Blocking Drugs with Angiotensin Type 1 Receptor [PDF]

Journal of Chemical Information and Modeling, 2017
Crystal structures of the human angiotensin II type 1 receptor (AT1R) complex with the antihypertensive agent ZD7155 (PDB id: 4YAY ) and the blood pressure medication Benicar (PDB id: 4ZUD ) showed that binding poses of both antagonists are similar. This finding implies that clinically used angiotensin receptor blocking (ARB) drugs may interact in a ...
Khuraijam Dhanachandra Singh, Hamiyet Unal, Russell Desnoyer, Sadashiva S. Karnik   +3 more
openaire   +2 more sources

Mechanisms With Clinical Implications for Atrial Fibrillation–Associated Remodeling: Cathepsin K Expression, Regulation, and Therapeutic Target and Biomarker [PDF]

, 2014
Background: The cysteine protease cathepsin K (CatK) has been implicated in the pathogenesis of cardiovascular disease. We sought to determine the link between atrial fibrillation (AF) and plasma CatK levels and to investigate the expression of and ...
Cheng, Xian Wu, Fujita, Masaya, Inden, Yasuya, Inoue, Aiko, Kuzuya, Masafumi, Kyo, Seifuku, Murohara, Toyoaki, Okumura, Kenji, Shi, Guo‐Ping, Shimano, Masayuki, Taguchi, Noriko, Takeshita, Kyosuke, Yamamoto, Toshihiko, Yoshida, Naoki   +13 more
core   +1 more source

Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet [PDF]

, 2017
AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl ...
Cao, Gabriel Fernando, Choi, Marcelo Roberto, Della Penna, Silvana Lorena, Fernandez, Belisario Enrique, Gorzalczany, Susana Beatriz, Kouyoumdzian, Nicolás Martín, Roson, Maria Ines, Toblli, Jorge Eduardo   +7 more
core   +1 more source

Differential Regulation of Intracisternally Injected Angiotensin II-Induced Mechanical Allodynia and Thermal Hyperalgesia in Rats

Biomedicines, 2023
The present study examined the underlying mechanisms of mechanical allodynia and thermal hyperalgesia induced by the intracisternal injection of angiotensin (Ang) II.
Ki-Don Park, Jo-Young Son, Hak-Kyun Kim, Yu-Mi Kim, Jin-Sook Ju, Min-Jeong Jo, Min-Kyoung Park, Min-Kyung Lee, Dong-Kuk Ahn   +8 more
doaj   +1 more source