Results 21 to 30 of about 395,425 (304)

Differential Regulation of Intracisternally Injected Angiotensin II-Induced Mechanical Allodynia and Thermal Hyperalgesia in Rats

open access: yesBiomedicines, 2023
The present study examined the underlying mechanisms of mechanical allodynia and thermal hyperalgesia induced by the intracisternal injection of angiotensin (Ang) II.
Ki-Don Park   +8 more
doaj   +1 more source

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors

open access: yesScience Signaling, 2018
Bioluminescence-based biosensors enable comprehensive profiling of G protein–coupled receptor signaling bias. Biosensors for GPCR-biased signaling Upon binding to ligands, G protein–coupled receptors (GPCRs) stimulate heterotrimeric G proteins and ...
Y. Namkung   +15 more
semanticscholar   +1 more source

Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism [PDF]

open access: yesHormone and Metabolic Research, 2020
AbstractPrimary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA.
Meyer L. S.   +3 more
openaire   +5 more sources

Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade. [PDF]

open access: yesPLoS ONE, 2016
Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity.
Kana Tsukuda   +12 more
doaj   +1 more source

Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies

open access: yesKidney International Reports, 2019
Introduction: Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non–human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific ...
Meghan H. Pearl   +8 more
doaj   +1 more source

Type 1 angiotensin II receptors in human endometrium [PDF]

open access: yesMolecular Human Reproduction, 1996
From evidence based on the use of specific receptor subtype antagonists, it has generally been assumed that human uterine tissue contains only type 2 (AT2) angiotensin II (AII) receptor subtype. Using a monoclonal antibody, 6313/G2, directed against a specific sequence in the extracellular domain of the type 1 AII receptor (AT1), in immunocytochemical ...
E, Saridogan   +6 more
openaire   +2 more sources

ANGIOTENSIN II TYPE 1 RECEPTOR AUTOANTIBODIES

open access: yesJournal of Hypertension, 2019
Objective:Primary aldosteronism (PA), the most common cause of endocrine hypertension, is a disorder due to bilateral adrenal hyperplasia (BAH) and aldosterone producing adenoma (APA), featuring concentrations of plasma aldosterone that are inappropriately high for the circulating renin levels ...
M. Piazza   +4 more
openaire   +2 more sources

Angiotensin II type 2 receptor–interacting protein 3a inhibits ovarian carcinoma metastasis via the extracellular HMGA2-mediated ERK/EMT pathway

open access: yesTumor Biology, 2017
Local migration and long-distance metastasis is the main reason for higher mortality of ovarian cancer. Microtubule-associated tumor suppressor 1/angiotensin II type 2 receptor–interacting protein is associated with tumor initiation and progression and ...
Ping Huang   +3 more
doaj   +1 more source

Roles and functions of Atp6ap2 in the brain

open access: yesNeural Regeneration Research, 2018
The classical renin-angiotensin system (RAS) in the body has been studied intensively in the last decades, since it is known that this system is involved in the regulation of blood pressure.
Alexander Bracke   +1 more
doaj   +1 more source

The angiotensin II type 1 receptor and receptor-associated proteins [PDF]

open access: yesCell Research, 2001
The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II.
D F, Guo, Y L, Sun, P, Hamet, T, Inagami
openaire   +2 more sources

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